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doi:10.1111/php.1999.69.issue-1

Cited by 6 publications

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“…It has been shown that knowledge of photosensitizer fluorescence intensity and/or changes in photosensitizer spectral properties before and during treatment may be related to therapeutic efficacy and can be used to monitor PDT. [9][10][11][12] Despite the potential usefulness of in-vivo fluorescence spectroscopy, the exact quantification of fluorescent signals is challenging. When measuring fluorescence in vivo, the number of collected photons is strongly influenced by optical properties of the tissue under investigation.…”

Section: Introductionmentioning

confidence: 99%

Intrinsic photosensitizer fluorescence measured using multi-diameter single-fiber spectroscopyin vivo

et al. 2014

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Quantification of fluorescence in vivo is complicated by the influence of tissue optical properties on the collected fluorescence signal. When tissue optical properties in the measurement volume are quantified, one can obtain the intrinsic fluorescence, which equals the product of fluorophore absorption coefficient and quantum yield. We applied this method to in vivo single-fiber fluorescence spectroscopy measurements on mouse tongue, skin, liver, and oral squamous cell carcinoma, where we detected intrinsic fluorescence spectra of the photosensitizers chlorin e6 and Bremachlorin at t=[3,4.5,6,24,48] h incubation time. We observed a tissue-dependent maximum of 35% variation in the total correction factor over the visible wavelength range. Significant differences in spectral shape over time between sensitizers were observed. Although the wavelength position of the fluorescence intensity maximum for ce6 shifted to the red, Bremachlorin showed a blue shift. Furthermore, the Bremachlorin peak appeared to be broader than the ce6 fluorescence peak. Intrinsic fluorescence intensity, which can be related to photosensitizer concentration, was decreasing for all time points but showed significantly more Bremachlorin present compared to ce6 at long incubation times. Results from this study can be used to define an optimal treatment protocol for Bremachlorin-based photodynamic therapy.

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Section: Introductionmentioning

confidence: 99%

Intrinsic photosensitizer fluorescence measured using multi-diameter single-fiber spectroscopyin vivo

et al. 2014

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Stemness and differentiation potential-recovery effects of sinapic acid against ultraviolet-A-induced damage through the regulation of p38 MAPK and NF-κB

Hwang

Park

Kang

et al. 2017

Sci Rep

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Ultraviolet A (UVA) irradiation exerts negative effects on stemness and differentiation potential of stem cells. This study aimed to explore the effect of sinapic acid on UVA-irradiation-induced damages to stemness and differentiation potential of human-adipose-tissue-derived mesenchymal stem cells (hAMSCs) and its UVA-antagonist mechanisms. Sinapic acid attenuated UVA-induced reduction in the proliferative potential and stemness by upregulating OCT4, SOX2, and NANOG. In addition, sinapic acid significantly recovered UVA-induced reduction in expression level of hypoxia-inducible factor (HIF)-1α. The antagonist effect of sinapic acid against stemness damage was mediated by reduceing PGE2 production through inhibition of p38 MAPK and NF-κB. Moreover, sinapic acid attenuated UVA-induced reduction in differentiation potential by downregulating the expression of macrophage migration inhibitory factor (MIF) and Kruppel-like factor (KLF) 2 gene while activating AMP-activated protein kinase (AMPK). UVA-induced inhibition of adipogenic differentiation was mediated by reducing MIF production through suppression of NF-κB. Taken together, these findings suggest that sinapic acid may ameliorate UVA-irradiation-induced reduced stemness and differentiation potential of hAMSCs. Therefore, sinapic acid might have potential as an antagonist agent to attenuate damages caused by UVA.

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Quenching of fluorescence by meclizine, a probe study for structural and conformational changes in human serum albumin

Ariga

Naik

Nandibewoor

et al. 2016

Journal of Biomolecular Structure and Dynamics

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The goal of this study was to investigate the interactions between meclizine (MEC) and human serum albumin (HSA) under physiological conditions by different spectroscopies and molecular modeling technique. The drug, MEC quenched the intrinsic fluorescence of HSA and the analysis of the results revealed that static quenching mechanism. The binding of MEC quenches the HSA fluorescence; stoichiometry was 1:1 interaction. Thermodynamic quantities were calculated at different temperatures suggested that hydrophobic and van der Waals interaction with HSA-MEC. The molecular distance, r, between donor and acceptor was estimated according to Forster's theory of non-radiation energy transfer. CD and FT-IR studies confirm changes of secondary structure of HSA. Molecular docking studies validate MEC molecule interact to HSA in sub domain IIA.

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Cited by 6 publications

References 0 publications

Intrinsic photosensitizer fluorescence measured using multi-diameter single-fiber spectroscopyin vivo

Intrinsic photosensitizer fluorescence measured using multi-diameter single-fiber spectroscopyin vivo

Stemness and differentiation potential-recovery effects of sinapic acid against ultraviolet-A-induced damage through the regulation of p38 MAPK and NF-κB

Quenching of fluorescence by meclizine, a probe study for structural and conformational changes in human serum albumin

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