DPPH radical scavenging activity of two flavonol glycosides from Aconitum napellus sp. lusitanicum

Luis, Juan; Valdés, Francisco; Martin, R.R.; Carmona, Armando J.; Dı́az, Jesús

doi:10.1016/j.fitote.2006.05.018

Cited by 15 publications

(7 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To detect radical-scavenging potential of purified compounds, we used three different free radical systems. The EC 50 values obtained for purified substances by DPPH assay were in a concentration range of 2.7-4.2 g/mL (8 × 10 −3 -1 × 10 −2 mol/mL), which is in agreement with earlier studies (Luis et al, 2006). Flavonoids from plant sources are well known free radical scavenging substances (Pérez-Jiménez and Saura-Calixto, 2008).…”

Section: Discussionsupporting

confidence: 90%

Free radical scavenging activities and inhibition of inflammatory enzymes of phenolics isolated from Tripodanthus acutifolius

Soberón¹,

Sgariglia²,

Sampietro³

et al. 2010

Journal of Ethnopharmacology

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 90%

Free radical scavenging activities and inhibition of inflammatory enzymes of phenolics isolated from Tripodanthus acutifolius

Soberón¹,

Sgariglia²,

Sampietro³

et al. 2010

Journal of Ethnopharmacology

View full text Add to dashboard Cite

“…From literature survey, it was proved that Aconitum napellus Linn. possesses Quercetin3-O-(6-transcaffeoyl)-βglucopyranosyl-(1→2)-β-glucopyranosyl-7-O-αrhamnopyranoside and quercetin-3-sophoroside-7rhamnopyranoside [25]. Apart from this, it also possesses alkaloid, carbohydrate, glycosides, protein, flavonoid, tannin but it is devoid of terpene, gum & mucilage and steroid.…”

Section: Phytochemical Evaluationmentioning

confidence: 99%

Untitled

2023

IPCM

View full text Add to dashboard Cite

Objective:The primary focus of the research work is to explore the antioxidant potential of ethanolic root extract of Aconitum napellus Linn. (EEAN).Methods: Different methods like DPPH scavenging activity, hydroxyl radical scavenging activity, and nitric oxide scavenging activity was followed to evaluate the in vitro antioxidant profile. HPTLC fingerprint investigation was executed for qualitative determination of a promising number of constituents from the ethanolic extract. OECD guideline 423 was followed for the determination of acute toxicity in Wistar rat. Results:The total yield was found 0.948% from the ethanolic root extract. The results revealed that the ethanolic root extract of Aconitum napellus Linn. possesses good antioxidant activity in a concentration-dependent manner. According to DPPH radical scavenging assay, a concentration of 494.50 ± 2.62 µg/ml of antioxidant material essential to rummage 50% of free radical. The ethanolic extract holds an IC50 value of 579.57 ± 1.85µg and 469.56 ± 2.16 µg as determined by hydroxyl radical scavenging assay and nitric Oxide scavenging assay respectively. The plant extract possesses significant dose-dependent (0.284 ± 0.0018 at 125 µg/ml and 0.923 ± 0.0003 at 500 µg/ml) reducing capacity. HPTLC fingerprint information supports numerous fundamental pieces of evidence like isolation, purification, quality assessment and standardization. Aconitum napellus Linn. was found to be highly toxic at a dose of 2000 mg/Kg which was confirmed by the death of the rat. Therefore, the LD50 of this ethanolic root extract was estimated to be ≥2000 mg/kg. Conclusion:The Aconitum napellus ethanolic root extract in this study showed potential to be used as a natural antioxidant at a limited concentration. Root extracts from this plant might have potential applications in pharmaceutical and cosmeceutical formulations in the future.

show abstract

“…These compounds dose-dependently inhibited the expressions of iNOS and COX-2 and their mRNA levels. lusitanicum (Luis et al, 2006), A. burnatii, A. variegatum (Vitalini et al, 2010), and A. anthora (Mariani et al, 2008), some of which showed antioxidant activities. lusitanicum (Luis et al, 2006), A. burnatii, A. variegatum (Vitalini et al, 2010), and A. anthora (Mariani et al, 2008), some of which showed antioxidant activities.…”

Section: A Quercetin 3-o-b-d-glucopyranoside-7-o-(6-e-p-coumaroyl)-b-mentioning

confidence: 99%

Chemical and biological studies of Aconitum pharmaceutical resources

Hao¹,

Gu²,

Xiao³

2015

Medicinal Plants

View full text Add to dashboard Cite

DPPH radical scavenging activity of two flavonol glycosides from Aconitum napellus sp. lusitanicum

Cited by 15 publications

References 5 publications

Free radical scavenging activities and inhibition of inflammatory enzymes of phenolics isolated from Tripodanthus acutifolius

Free radical scavenging activities and inhibition of inflammatory enzymes of phenolics isolated from Tripodanthus acutifolius

Untitled

Chemical and biological studies of Aconitum pharmaceutical resources

Contact Info

Product

Resources

About