Doxorubicin-loaded Niosomes functionalized with gelatine and alginate as pH-responsive drug delivery system: A 3D printing approach

Zaer, Mohammad; Moeinzadeh, Alaa; Abolhassani, Hossein; Rostami, Neda; Tavakkoli Yaraki, Mohammad; Seyedi, Seyed Arsalan; Nabipoorashrafi, Seyed Ali; Bashiri, Zahra; Moeinabadi-Bidgoli, Kasra; Moradbeygi, Fatemeh; Farmani, Ahmad Reza; Hossein-Khannazer, Nikoo

doi:10.1016/j.ijbiomac.2023.126808

Cited by 16 publications

(2 citation statements)

References 79 publications

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“…The results demonstrated that the designed nanocarriers presented a greater than 95% cytotoxicity against breast cancer cells and a greater than 90% cell viability. Moreover, the use of 3D printing for the production of smart drug delivery devices at a large scale is feasible, and the designed nanocarriers demonstrated efficacy for further research on cancer therapies [179].…”

Section: Proteinsmentioning

confidence: 99%

An Approach to 3D Printing Techniques, Polymer Materials, and Their Applications in the Production of Drug Delivery Systems

Cardoso,

Araújo

2024

Compounds

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Three-dimensional printing (3DP) technologies are characterized as a set of innovative manufacturing techniques that allow for the creation of complex and/or personalized three-dimensional physical objects on the work surface of a 3D printing machine (based on the computer-aided design (CAD) project designs of these parts). Three-dimensional printing techniques are widely used in various areas of knowledge, such as education, engineering, and biomedicine. Polymeric materials are widely used for these applications, mainly due to their desirable workability during part manufacturing, compatibility with other chemical materials, the wide range of polymers with different physical and chemical characteristics, and the possibility for recycling. The development of polymeric drug delivery systems (DDSs) by 3D printing is currently an active field of research, both in academia and industry, given the potential of this technique for medical purposes. In this context, this work reviews potential polymers for the production of drug delivery systems via 3D printing techniques. The demonstrations of the main 3DP techniques used for drug delivery applications include their working principles and advantages and how the technologies develop the final product. In addition, potential synthetic and natural polymers that are currently used in 3DP drug delivery devices are presented and discussed based on recent scientific studies.

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Section: Proteinsmentioning

confidence: 99%

An Approach to 3D Printing Techniques, Polymer Materials, and Their Applications in the Production of Drug Delivery Systems

Cardoso,

Araújo

2024

Compounds

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“…Biodegradable porous scaffolds should guide vascular infiltration and help cell migration in order to be a suitable dermal substitute for wound healing. − It is shown that the scaffolds’ optimal pore size should be large to permit cell proliferation, attachment, and migration. However, scaffolds usually cannot inhibit inflammation and infection .…”

Section: Introductionmentioning

confidence: 99%

3D Printing of Alginate/Chitosan-Based Scaffold Empowered by Tyrosol-Loaded Niosome for Wound Healing Applications: In Vitro and In Vivo Performances

Beram,

Ali,

Mesbahian

et al. 2024

ACS Appl. Bio Mater.

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spinning and 3D printing techniques for wound healing applications. The niosomes, measuring 185.40 ± 6.40 nm with a polydispersity index of 0.168 ± 0.012, encapsulated tyrosol with an efficiency of 77.54 ± 1.25%. The scaffold's microsized porous structure (600−900 μm) enhances water absorption, promoting cell adhesion, migration, and proliferation. Mechanical property assessments revealed the scaffold's enhanced resilience, with niosomes increasing the compressive strength, modulus, and strain to failure, indicative of its suitability for wound healing. Controlled tyrosol release was demonstrated in vitro, essential for therapeutic efficacy. The scaffold exhibited significant antibacterial activity against Pseudomonas aeruginosa and Staphylococcus aureus, with substantial biofilm inhibition and downregulation of bacterial genes (ndvb and icab). A wound healing assay highlighted a notable increase in MMP-2 and MMP-9 mRNA expression and the wound closure area (69.35 ± 2.21%

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Exploring Advanced CRISPR Delivery Technologies for Therapeutic Genome Editing

Rostami,

Gomari,

Choupani

et al. 2024

Small Science

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The genetic material within cells plays a pivotal role in shaping the structure and function of living organisms. Manipulating an organism's genome to correct inherited abnormalities or introduce new traits holds great promise. Genetic engineering techniques offers promising pathways for precisely altering cellular genetics. Among these methodologies, clustered regularly interspaced short palindromic repeat (CRISPR), honored with the 2020 Nobel Prize in Chemistry, has garnered significant attention for its precision in editing genomes. However, the CRISPR system faces challenges when applied in vivo, including low delivery efficiency, off‐target effects, and instability. To address these challenges, innovative technologies for targeted and precise delivery of CRISPR have emerged. Engineered carrier platforms represent a substantial advancement, improving stability, precision, and reducing the side effects associated with genome editing. These platforms facilitate efficient local and systemic genome engineering of various tissues and cells, including immune cells. This review explores recent advances, benefits, and challenges of CRISPR‐based genome editing delivery. It examines various carriers including nanocarriers (polymeric, lipid‐derived, metallic, and bionanoparticles), viral particles, virus‐like particles, and exosomes, providing insights into their clinical utility and future prospects.

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Doxorubicin-loaded Niosomes functionalized with gelatine and alginate as pH-responsive drug delivery system: A 3D printing approach

Cited by 16 publications

References 79 publications

An Approach to 3D Printing Techniques, Polymer Materials, and Their Applications in the Production of Drug Delivery Systems

An Approach to 3D Printing Techniques, Polymer Materials, and Their Applications in the Production of Drug Delivery Systems

3D Printing of Alginate/Chitosan-Based Scaffold Empowered by Tyrosol-Loaded Niosome for Wound Healing Applications: In Vitro and In Vivo Performances

Exploring Advanced CRISPR Delivery Technologies for Therapeutic Genome Editing

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