Doxorubicin-Loaded Cyclic Peptide Nanotube Bundles Overcome Chemoresistance in Breast Cancer Cells

Wang, Yongzhong; Yi, Sijia; Sun, Leming; Huang, Yujian; Lenaghan, Scott C.; Zhang, Mingjun

doi:10.1166/jbn.2014.1724

Cited by 52 publications

(31 citation statements)

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“…A method reported by Zhang et al [47] was used in this study to analysis the P-gp functional activity of cancer cells. Briefly, MCF-7/ADR or MCF-7 cells were seeded into 12-well plates at a density of 1 × 10 5 cell/well for MCF-7/ADR cells, and 0.5 × 10 5 cell/well for MCF-7 cells.…”

Section: Methodsmentioning

confidence: 99%

Quercetin and doxorubicin co-encapsulated biotin receptor-targeting nanoparticles for minimizing drug resistance in breast cancer

Liu

Chen

et al. 2016

Oncotarget

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The combination of a chemotherapeutic drug with a chemosensitizer has emerged as a promising strategy for cancers showing multidrug resistance (MDR). Herein we describe the simultaneous targeted delivery of two drugs to tumor cells by using biotin-decorated poly(ethylene glycol)-b-poly(ε-caprolactone) nanoparticles encapsulating the chemotherapeutic drug doxorubicin and the chemosensitizer quercetin (BNDQ). Next, the potential ability of BNDQ to reverse MDR in vitro and in vivo was investigated. Studies demonstrated that BNDQ was more effectively taken up with less efflux by doxorubicin-resistant MCF-7 breast cancer cells (MCF-7/ADR cells) than by the cells treated with the free drugs, single-drug–loaded nanoparticles, or non-biotin–decorated nanoparticles. BNDQ exhibited clear inhibition of both the activity and expression of P-glycoprotein in MCF-7/ADR cells. More importantly, it caused a significant reduction in doxorubicin resistance in MCF-7/ADR breast cancer cells both in vitro and in vivo, among all the groups. Overall, this study suggests that BNDQ has a potential role in the treatment of drug-resistant breast cancer.

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Section: Methodsmentioning

confidence: 99%

Quercetin and doxorubicin co-encapsulated biotin receptor-targeting nanoparticles for minimizing drug resistance in breast cancer

Liu

Chen

et al. 2016

Oncotarget

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“…Although polymer‐coated peptide‐based nanotubes appear to be highly suitable materials for the delivery of drugs, they have only barely been exploited for this purpose. One recent example is the use of polyethylene glycol (PEG)‐coated NTs for the delivery of doxorubicin 13…”

Section: Methodsmentioning

confidence: 99%

Drug Conjugation to Cyclic Peptide–Polymer Self‐Assembling Nanotubes

Blunden

Chapman

Danial

et al. 2014

Chemistry A European J

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We show for the first time how polymeric nanotubes (NTs) based on self-assembled conjugates of polymers and cyclic peptides can be used as an efficient drug carrier. RAPTA-C, a ruthenium-based anticancer drug, was conjugated to a statistical co-polymer based on poly(2-hydroxyethyl acrylate) (pHEA) and poly(2-chloroethyl methacrylate) (pCEMA), which formed the shell of the NTs. Self-assembly into nanotubes (length 200-500 nm) led to structures exhibiting high activity against cancer cells.

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“…For example, cyclic peptide self-assembled nanotubes have been prepared using eight-residue cyclic peptides containing Glu and Cys amino acids, which have been demonstrated for drug delivery applications [67]. The results have claimed that polyethylene glycol modified doxorubicin loaded nanotubes have high drug encapsulation ratio.…”

Section: Cyclic Peptidementioning

confidence: 99%

“…Moreover, the polyethylene glycol modified nanotubes with doxorubicin have shown their potential in multidrug resistance tumor therapy [67].…”

Section: Cyclic Peptidementioning

confidence: 99%

Peptide Self-Assembled Nanostructures for Drug Delivery Applications

Fan

Shen

et al. 2017

Journal of Nanomaterials

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Peptide self-assembled nanostructures are very popular in many biomedical applications. Drug delivery is one of the most promising applications among them. The tremendous advantages for peptide self-assembled nanostructures include good biocompatibility, low cost, tunable bioactivity, high drug loading capacities, chemical diversity, specific targeting, and stimuli responsive drug delivery at disease sites. Peptide self-assembled nanostructures such as nanoparticles, nanotubes, nanofibers, and hydrogels have been investigated by many researchers for drug delivery applications. In this review, the underlying mechanisms for the self-assembled nanostructures based on peptides with different types and structures are introduced and discussed. Peptide self-assembled nanostructures associated promising drug delivery applications such as anticancer drug and gene drug delivery are highlighted. Furthermore, peptide self-assembled nanostructures for targeted and stimuli responsive drug delivery applications are also reviewed and discussed.

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Doxorubicin-Loaded Cyclic Peptide Nanotube Bundles Overcome Chemoresistance in Breast Cancer Cells

Cited by 52 publications

References 0 publications

Quercetin and doxorubicin co-encapsulated biotin receptor-targeting nanoparticles for minimizing drug resistance in breast cancer

Quercetin and doxorubicin co-encapsulated biotin receptor-targeting nanoparticles for minimizing drug resistance in breast cancer

Drug Conjugation to Cyclic Peptide–Polymer Self‐Assembling Nanotubes

Peptide Self-Assembled Nanostructures for Drug Delivery Applications

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