2016
DOI: 10.1002/jcsm.12148
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Abstract: BackgroundDoxorubicin, a widely used anti‐tumour drug, is known to cause muscle loss in cancer patients.MethodsFollowing an acute dose of doxorubicin injection (2.5 mg/kg per body weight), we examined macrophage distribution in rat soleus muscle challenged by eccentric exercise (downhill running). Long‐term doxorubicin treatment (one injection every 3 days) on muscle mass and survival were also determined.ResultsUnder non‐exercised condition, increased tumour necrosis factor (TNF)‐alpha mRNA and decreased IL‐1… Show more

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Cited by 32 publications
(39 citation statements)
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“…In one study, the reduced body weight was sustained for 4 weeks after the cessation of chemotherapy . The decrease in body weight was accompanied by a reduction in skeletal muscle weight and a decrease in lean body mass and fat mass . Our meta‐analysis revealed that doxorubicin treatment significantly reduced skeletal muscle weight by 14% (95% CI: 9.9 to 19.3) compared to vehicle control (Figure ).…”
Section: Resultsmentioning
confidence: 82%
“…In one study, the reduced body weight was sustained for 4 weeks after the cessation of chemotherapy . The decrease in body weight was accompanied by a reduction in skeletal muscle weight and a decrease in lean body mass and fat mass . Our meta‐analysis revealed that doxorubicin treatment significantly reduced skeletal muscle weight by 14% (95% CI: 9.9 to 19.3) compared to vehicle control (Figure ).…”
Section: Resultsmentioning
confidence: 82%
“…In addition, we used conditioned medium (CM) containing inflammatory components from THP-1 monocytes and used DOX treatment to induce pyroptosis in Sol 8 cells. These experimental conditions simulate Dox induced inflammatory conditions which are typical of DIMT (Huang et al, 2017). Our results provide evidence that exosomes derived from ES cells inhibit pyroptosis in Sol 8 cells and these exosomes contain miRNAs which are protective in nature.…”
mentioning
confidence: 58%
“…Non-microbial sterile inflammation stimulus enhances pyroptosis in myocardial infarction (Takahashi, 2014). In the present study, we generated a Dox and inflammation induced injury model in Sol 8 cells which is typical of in vivo Dox induced skeletal muscle toxicity (Huang et al, 2017;Supriya et al, 2016). We examined the presence of pyroptosis using specific markers such as caspase-1 and IL-1β through immunohistochemistry and western blot analysis.…”
Section: Resultsmentioning
confidence: 99%
“…Although, the 10-week-old male rats used are sexually mature, the myogenic response to DOX may be different than that observed in older animals. It was reported previously that 6 month old rats had a somewhat different muscle repair signaling response to exercise and DOX at the mRNA level 35 and muscle from 4-5-month-old rats, had a blunted inflammatory response with DOX and exercise 36 . Nonetheless, the clinical application to the current study's finding should not be overlooked.…”
Section: Discussionmentioning
confidence: 81%