Doxapram alleviates low SpO2 induced by the combination of propofol and fentanyl during painless gastrointestinal endoscopy

Gu, Zhengfeng; Lian, Xin; Wang, Haoxing; Hu, Chunxiao; Wang, Zhiping; Lu, Shunmei; Xu, Jingjing; Qian, Yiling; Wang, Jun

doi:10.1186/s12871-019-0860-1

Cited by 2 publications

(2 citation statements)

References 20 publications

(20 reference statements)

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“…Propofol-based intravenous anesthesia is the main component of outpatient implementation of EGD under sedation techniques. However, there are certain risks and complications associated with intravenous anesthesia, the most common being a decrease in pulse oxygen saturation (SpO 2 ) and even the development of hypoxemia [2]. The sharing of the oropharyngeal cavity for EGD operations and anesthesia management leads to complex airway management and further increases the risk of hypoxemia.…”

Section: Introductionmentioning

confidence: 99%

Can the width of lower tongue base preoperative sonography measurements predict hypoxemia during esophagogastroduodenoscopy under sedation in ASA I-II patients?

Wu,

Xia,

Chen

et al. 2024

Med Ultrason

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Aim: The most common complication during esophagogastroduodenoscopy (EGD) under sedation is hypoxemia. There is a scarcity of indicators to predict the risk of hypoxemia during EGD under sedation accurately. The width of the lower tongue base measured by ultrasound (US) is considered to be a significant predictor of the presence and severity of obstructive sleepapnea syndrome (OSAS), which develops hypoxemia by a similar mechanism to EGD under sedation. This study aimed to observe its ability to predict hypoxemia during EGD under sedation.Material and methodsː Adult patients undergoing EGD under sedation at our hospital after assessment in the anesthesia clinic were enrolled in the study. The width of the lower tongue base was measured as the distance between the lingual arteries (DLA) on both sides of the inferior lateral margin of the tongue by US. The primary outcome was hypoxemia defined as the SpO2 <90% for longer than 10 seconds during EGD under sedation. ResultsːA total of 304 patients were successfully included, and hypoxemia was reported in 32 patients (10.5%). The DLA prediction criterion for hypoxemia was >31 mm. The DLA was correlated with hypoxemia (Spearman correlation coefficient, 0.455; p<0.001) and owned the highest area under the receiver operating characteristic curve (0.927; 99% CI, 0.891 to 0.953, compared with that of the other predictors, p< 0.001) with hypoxemia.Conclusionsː The width of the lower tongue base, measured as the DLA by US examination can be used to effectively predict the risk of hypoxemia during EGD under sedation.

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Section: Introductionmentioning

confidence: 99%

Can the width of lower tongue base preoperative sonography measurements predict hypoxemia during esophagogastroduodenoscopy under sedation in ASA I-II patients?

Wu,

Xia,

Chen

et al. 2024

Med Ultrason

View full text Add to dashboard Cite

show abstract

“…However, there are certain risks and complications associated with intravenous anesthesia. The most commonly seen symptom would be decrease in blood oxygen saturation (SPO 2 ) and may further develop into hypoxemia [2] . The other fact is that EGD operations and anesthesia management share the oropharyngeal cavity and therefore complicates the process of airway management.…”

Section: Introductionmentioning

confidence: 99%

Can width of lower tongue base preoperative sonography measurements predict hypoxemia during esophagogastroduodenoscopy under sedation?

Xia

Chen

et al. 2022

Preprint

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Background: The most common complication during esophagogastroduodenoscopy (EGD) under sedation is a decrease in pulse oxygen saturation (SpO2) and even the development of hypoxemia. The width of the lower tongue base measured by ultrasound is considered to be a significant predictor of the presence and severity of obstructive sleep apnea syndrome (OSAS). This study aimed to observe the capability of the width of the lower tongue base measured by ultrasound to predict hypoxemia during EGD under sedation. Methods: Adult patients undergoing EGD under sedation at our hospital after assessment in the anesthesia clinic were enrolled in the study. The width of the lower tongue base was measured as the distance between the lingual arteries (DLA) on both sides of the inferior lateral margin of the tongue by ultrasound. Beside weight and height were recorded. The primary outcome was hypoxemia defined as the SpO2 < 90% at any time during EGD under sedation. Results: A total of 304 patients were successfully included, and hypoxemia was reported in 32 patients. The DLA prediction criterion for hypoxemia was ＞31 mm. The DLA was correlated with hypoxemia (Spearman correlation coefficient, 0.455; P <0.001) and owned the highest area under the receiver operating characteristic curve (0.927; 99% CI, 0.891 to 0.953, compared with that of the other predictors, P < 0.001) with hypoxemia. Conclusions: The width of the lower tongue base, measured as the DLA by ultrasound examination can be used to predict the risk of hypoxemia during EGD under sedation effectively. In addition, compared with BMI, DLA measured by ultrasound examination exhibits improved predictive capabilities. Trial registration: ChiCTR, ChiCTR2000032940, 16/05/2020. https://www.chictr.org.cn/index.aspx

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Doxapram alleviates low SpO2 induced by the combination of propofol and fentanyl during painless gastrointestinal endoscopy

Cited by 2 publications

References 20 publications

Can the width of lower tongue base preoperative sonography measurements predict hypoxemia during esophagogastroduodenoscopy under sedation in ASA I-II patients?

Can the width of lower tongue base preoperative sonography measurements predict hypoxemia during esophagogastroduodenoscopy under sedation in ASA I-II patients?

Can width of lower tongue base preoperative sonography measurements predict hypoxemia during esophagogastroduodenoscopy under sedation?

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