Arch Otolaryngol Head Neck Surg
 2009
DOI: 10.1001/archoto.2008.560
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Downregulation of TESTIN and Its Association With Cancer History and a Tendency Toward Poor Survival in Head and Neck Squamous Cell Carcinoma

Esra Gündüz
1
,
Mehmet Gündüz
2
,
Levent Beder
3
et al.

Abstract: Our findings suggest that inactivation of TESTIN is involved in head and neck carcinogenesis through its downregulation. Further studies in various human cancer tissues using a large sample size and in vitro functional studies as well as clinical comparison research studies would give us a better evaluation of TESTIN's role and its possible future application in molecular diagnosis and treatment of different cancer types, including head and neck squamous cell carcinoma.

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Cited by 17 publications

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“…However, no mutation was detected in these two exons in our study. A heterozygous mutation at codon 221 in exon 4 of TES has been reported in the breast cancer cell line MDA-MB 453 [9] and in head and neck squamous cell carcinoma tissues [8]. Similarly, the same mutation in exon 4 was also detected in HGC27 GC cells in this study.…”
Section: Discussionsupporting
confidence: 82%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…However, no mutation was detected in these two exons in our study. A heterozygous mutation at codon 221 in exon 4 of TES has been reported in the breast cancer cell line MDA-MB 453 [9] and in head and neck squamous cell carcinoma tissues [8]. Similarly, the same mutation in exon 4 was also detected in HGC27 GC cells in this study.…”
Section: Discussionsupporting
confidence: 82%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Recently, Ma et al [ 90 ], showed that TES is down-regulated in primary gastric cancer tissues and its expression level correlates with prognosis: patients with a loss of expression of TES had a shorter life span than those with an expressing tumor. The same prognostic correlation has been also found for head and neck squamous carcinomas [ 91 ].…”
Section: Otherssupporting
confidence: 74%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…( 27–30 ) Recently, more and more studies have indicated that TES may act as a tumor suppressor gene in tumorigenesis, ( 31 ) metastasis, ( 11 ) and prognosis. ( 32,33 ) In this study, when we tested the frequency of loss of heterozygosity by microsatellite analysis, 34.6% cases presented at least one marker lost. As to our results, eight of nine cases indicated loss of heterozygosity with a decline of TES expression.…”
Section: Discussionmentioning
confidence: 80%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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