Downregulation of Notch4 – a prognostic marker in distinguishing oral verrucous carcinoma from oral squamous cell carcinoma

Harishankar, M.; Mohan, Alok; Krishnan, Aswini; Devi, Arikketh

doi:10.1016/j.bjorl.2017.09.005

Cited by 5 publications

(5 citation statements)

References 27 publications

(23 reference statements)

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“…Finally, although a review on the prognosis of P-OSCC has recently been published (González-Moles et al, 2021), it was not guided by the most recent preferred reporting items for systematic reviews and meta-analyses checklist (Page et al, 2021) and included verrucous carcinomas as a malignant transformation type. Since lymph node and distant metastases are very rare in verrucous carcinomas and therefore have a better prognosis than OSCC (Harishankar et al, 2019), this can directly impact the real prognostic impact of the disease when compared to conventional OSCC. Thus, we believe that this review will add to the understanding of the specific prognosis of P-OSCC, highlighting the analysis of important prognostic information, such as recurrence, new primary tumours and metastases.…”

Section: Ta B L E 1 (Continued)mentioning

confidence: 99%

Prognostic outcomes of oral squamous cell carcinoma derived from proliferative verrucous leukoplakia: A systematic review

et al. 2022

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Proliferative verrucous leukoplakia (PVL) is a potentially malignant oral disorder first described by Hansen et al. (1985). It is characterized as a distinct aggressive form of oral leukoplakia, due to its progressive and multifocal behaviour, characterized by relapses, spreading and high rates of malignant transformation (Bombeccari Giannì et al., 2018;Hansen et al., 1985). Its aetiology is not related to known risk factors for conventional oral leukoplakia or oral squamous cell carcinomas (OSCCs), such as tobacco and alcohol; however, some genetic factors have been observed in PVL but without a definition of pathogenesis and aetiology (El-Naggar et al., 2017;Okoturo et al., 2018).PVL has distinct clinical stages, such as the appearance of one or more white plaques or spots on the oral mucosa; the increase and spread of these lesions to cover other sites; a verrucous surface appearance to some or all the leukoplakia and, finally, malignant transformation into verrucous carcinoma or OSCC (Gillenwater et al.,

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Section: Ta B L E 1 (Continued)mentioning

confidence: 99%

Prognostic outcomes of oral squamous cell carcinoma derived from proliferative verrucous leukoplakia: A systematic review

et al. 2022

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“… 313 Early diagnosis holds the potential to positively impact the survival rates of OSCC. Research indicates that Notch receptors, specifically Notch1, 314 , 315 Notch3, 316 and Notch4, 317 , 318 exhibit high levels in human OSCC tissues and are associated with a poor prognosis. This suggests that Notch receptors could serve as biomarkers for the early diagnosis of OSCC.…”

Section: The Notch Signaling Pathway and Cancermentioning

confidence: 99%

Notch signaling pathway in cancer: from mechanistic insights to targeted therapies

Shi,

Xue,

Zeng

et al. 2024

Sig Transduct Target Ther

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Notch signaling, renowned for its role in regulating cell fate, organ development, and tissue homeostasis across metazoans, is highly conserved throughout evolution. The Notch receptor and its ligands are transmembrane proteins containing epidermal growth factor-like repeat sequences, typically necessitating receptor-ligand interaction to initiate classical Notch signaling transduction. Accumulating evidence indicates that the Notch signaling pathway serves as both an oncogenic factor and a tumor suppressor in various cancer types. Dysregulation of this pathway promotes epithelial-mesenchymal transition and angiogenesis in malignancies, closely linked to cancer proliferation, invasion, and metastasis. Furthermore, the Notch signaling pathway contributes to maintaining stem-like properties in cancer cells, thereby enhancing cancer invasiveness. The regulatory role of the Notch signaling pathway in cancer metabolic reprogramming and the tumor microenvironment suggests its pivotal involvement in balancing oncogenic and tumor suppressive effects. Moreover, the Notch signaling pathway is implicated in conferring chemoresistance to tumor cells. Therefore, a comprehensive understanding of these biological processes is crucial for developing innovative therapeutic strategies targeting Notch signaling. This review focuses on the research progress of the Notch signaling pathway in cancers, providing in-depth insights into the potential mechanisms of Notch signaling regulation in the occurrence and progression of cancer. Additionally, the review summarizes pharmaceutical clinical trials targeting Notch signaling for cancer therapy, aiming to offer new insights into therapeutic strategies for human malignancies.

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“…O Carcinoma Verrucoso (CV) é visto como uma variante incomum e bem diferenciada do carcinoma de células escamosas (CEC). No entanto, apesar de ser considerado um tumor com características de malignidade, é possível observar em seu processo de desenvolvimento, algumas características de tumor benigno, tais como: padrão de crescimento mais expansivo do que invasivo, crescimento lento e uma boa diferenciação celular (MORAES, 2005;ZANINE et al, 2004;ALVAREZ et al, 2014;ADORNO et al, 2010;HARISHANKAR et al, 2017).…”

Section: Introductionunclassified

“…Devido à característica de crescimento lento e indolor, essa patologia pode revelar um longo período de história clínica. Ainda que seja uma patologia com bom prognóstico em estágios iniciais, o CV é capaz de se tornar localmente agressivo se não diagnosticado e tratado, podendo até invadir os tecidos adjacentes (ADORNO et al, 2010;HARISHANKAR et al, 2017;NEVILLE et al, 2016;MORAES, 2005;FRANKLYN et al, 2017).…”

Section: Introductionunclassified

“…Pelo fato de as células individuais não serem muito displásicas, o patologista deve examinar a configuração histomorfológica global da lesão para chegar ao diagnóstico correto, uma espécime adequada é importante, uma vez que algumas dessas lesões podem apresentar CEC, desenvolvendo-se frequentemente no interior do CV. Uma espécime cirúrgica compatível também é importante para permitir adequada diferenciação com o CEC e outras causas de hiperplasia pseudo-epiteliomatosa(ZANINE et al, 2004;ROSA et al, 2003;HARISHANKAR et al, 2017;NEVILLE et al, 2016).…”

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Carcinoma verrucoso em lábio inferior em uma paciente idosa: relato de caso

Chagas¹,

Fernandes²,

Santos³

et al. 2019

Acervo Saúde

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Introdução: O Carcinoma Verrucoso (CV) é visto como uma variante incomum e bem diferenciada do Carcinoma Espinocelular (CEC). No entanto, apesar de ser considerado um tumor de características maligno, é possível observar em seu processo de desenvolvimento, algumas características de tumor benigno. O objetivo deste relato de caso é relatar um caso clínico de uma paciente do gênero feminino portadora de carcinoma verrucoso. Detalhamento do caso: Relata-se um caso clínico de uma paciente do gênero feminino, 92 anos, que buscou atendimento após o surgimento de um tumor há aproximadamente três meses em região de mucosa labial inferior. Após avaliação clínica, foi realizada a remoção parcial da lesão através da biópsia incisional e envio do espécime cirúrgico para o exame histopatológico. O laudo histopatológico confirmou o diagnóstico de Carcinoma Verrucoso. Discussão: O CV é descrito como uma lesão que apresenta crescimento lento, sendo bem diferenciada e sem predisposição metastática. A sua localização mais comum corresponde à área de colocação crônica do tabaco. Na literatura há um consenso em que o tratamento de escolha é a exérese cirúrgica não havendo a necessidade de dissecção cervical, pois geralmente seu desenvolvimento é local.

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Downregulation of Notch4 – a prognostic marker in distinguishing oral verrucous carcinoma from oral squamous cell carcinoma

Cited by 5 publications

References 27 publications

Prognostic outcomes of oral squamous cell carcinoma derived from proliferative verrucous leukoplakia: A systematic review

Prognostic outcomes of oral squamous cell carcinoma derived from proliferative verrucous leukoplakia: A systematic review

Notch signaling pathway in cancer: from mechanistic insights to targeted therapies

Carcinoma verrucoso em lábio inferior em uma paciente idosa: relato de caso

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