PLoS ONE volume 9, issue 5, Pe98418 2014 DOI: 10.1371/journal.pone.0098418 View full text
Jun Lin, Qiang Zhang, Yi Lu, Wenrui Xue, Yue Xu, Yichen Zhu, Xiaopeng Hu

Abstract: Cisplatin-based combination chemotherapy regimen is a reasonable alternative to cystectomy in advanced/metastatic bladder cancer, but acquisition of cisplatin resistance is common in patients with bladder cancer. Previous studies showed that loss of homeodomain-interacting protein kinase-2 (HIPK2) contributes to cell proliferation and tumorigenesis. However, the role of HIPK2 in regulating chemoresistance of cancer cell is not fully understood. In the present study, we found that HIPK2 mRNA and protein levels …

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