Downregulation of autophagy-related gene ATG5 and GABARAP expression by IFN-λ1 contributes to its anti-HCV activity in human hepatoma cells

Li, Xu; Li, Yu; Fang, Shoucai; Su, Jinming; Jiang, Junjun; Liang, Bingyu; Huang, Jiegang; Zhou, Bo; Zang, Ning; Ho, Wen‐Zhe; Li, Jieliang; Li, Yi-Ping; Chen, Hui; Li, Ye; Liang, Hao

doi:10.1016/j.antiviral.2017.01.016

Cited by 19 publications

(18 citation statements)

References 58 publications

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“…Multiple studies have shown a significant association between history of tattooing and HCV infection. The present study was consistent with previous research from North America, Australia, and Italy, where the odds of being HCV positive increased by 3.4, 2.7, and 1.91, respectively in cases reporting a history of tattooing inside prison (37)(38)(39). Moreover, our findings could provide further evidence on the significant association between injecting frequency and HCV infection (29,30).…”

Section: Variables Correlated With Hcvsupporting

confidence: 93%

Hepatitis C Virus Seroprevalence and Associated Risk Factors Among Male Drug Injectors in Kermanshah, Iran

et al. 2017

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Background: Infection with hepatitis C virus (HCV) is increasingly recognized as a major global health problem. Objectives: The aim of this study was to measure the prevalence of HCV infection and determine the risk factors associated with HCV among male people who inject drugs (PWID) in Kermanshah, Iran. Methods: In this cross sectional study, the samples were recruited from 2 drop-in centers and related community outreach sites, using snowball sampling. The questionnaire consisted of 3 sections, including demographics, drug use patterns, and risky behaviors. HCV infection was tested in venous blood samples, collected from the participants, using the ABON rapid test kit. Logistic regression analysis was used to determine the association between HCV status and the associated factors, reported as odds ratio (OR) and 95% confidence interval (CI).

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Section: Variables Correlated With Hcvsupporting

confidence: 93%

Hepatitis C Virus Seroprevalence and Associated Risk Factors Among Male Drug Injectors in Kermanshah, Iran

et al. 2017

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“…(9) IFN-λ1 treatment inhibits autophagic activity in Huh7 cells by down-regulating the expression of ATG5 and aminobutyric acid receptor-associated protein through miR-181a and miR-214 and contributes to anti-HCV activity. (27) Together, these results support the notion that HCV-induced autophagy favors virus growth by negatively regulating the IFN response in the host cell.…”

Section: Interferon Responsesupporting

confidence: 67%

“…HCV‐induced autophagy also depletes TNF receptor‐associated factor 6, which, in turn, suppresses nuclear factor kappa B (NF‐κB) activation, induces proinflammatory cytokines (interleukin [IL]‐6 and tumor necrosis factor alpha [TNF‐α]), and enhances HCV replication . IFN‐λ1 treatment inhibits autophagic activity in Huh7 cells by down‐regulating the expression of ATG5 and aminobutyric acid receptor‐associated protein through miR‐181a and miR‐214 and contributes to anti‐HCV activity . Together, these results support the notion that HCV‐induced autophagy favors virus growth by negatively regulating the IFN response in the host cell.…”

Section: Innate Immune Response To Hcv Infectionsupporting

confidence: 63%

Hepatitis C Virus Manipulates Humans as its Favorite Host for a Long‐Term Relationship

Ray

2019

Hepatology

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Chronic hepatitis C virus (HCV) infection associated liver disease is a global health problem. HCV often causes silent disease, and eventually progresses to end stage liver disease. HCV infects hepatocytes, however initial manifestation of liver disease is mostly displayed in hepatic stellate cells causing fibrosis/cirrhosis, and believed to be occurring from inflammation in the liver. It is still unclear why HCV is not spontaneously cleared from infected liver in the majority of individuals and develops chronic infection with progressive liver disease. Direct-acting antivirals (DAAs) show excellent results in controlling viremia, although beneficial consequence in advanced liver disease remains to be understood. In this review, we highlight the current knowledge that has contributed in our understanding on the role of HCV in inflammation, immune evasion, metabolic disorders, liver pathogeneses, and efforts in vaccine development. This article is protected by copyright. All rights reserved.

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“…Some studies have suggested that PZA potentiation by the host may be related to drug upregulation of the autophagy pathway [96] . Multiple studies have reported the occurrence of dysregulated autophagy during diseases that cause altered immune states [97][98][99][100] While many outstanding questions remain, these studies indicate that the appropriate cell-mediated responses are critical for optimal PZA efficacy, and both local and systemic immune modulation are highly impactful for PZA efficacy.…”

Section: Pza and The Host Environmentmentioning

confidence: 99%

Impact of the host environment on the antitubercular action of pyrazinamide

Lamont

Baughn

2019

eBioMedicine

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a b s t r a c tPyrazinamide remains the only drug in the tuberculosis pharmacopeia to drastically shorten first-line therapy from nine to six months. Due to its unparalleled ability to sterilize non-replicating bacilli and reduce relapse rates, PZA is expected to be irreplaceable in future therapies against tuberculosis. While the molecular target of PZA is unclear, recent pharmacokinetic studies using small animal models and patient samples have highlighted the importance of host metabolism and immune responses in PZA efficacy. Delineating which host factors are important for PZA action will be integral to the design of next-generation therapies to shorten current TB drug regimens as well as to overcome treatment limitations in some patients. In this review, we discuss evidence for influence of the host environment on PZA activity, targets for PZA mechanism of action, recent studies in PZA pharmacokinetics, PZA antagonism and synergy with other first-line anti-TB drugs, and implications for future research.

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Downregulation of autophagy-related gene ATG5 and GABARAP expression by IFN-λ1 contributes to its anti-HCV activity in human hepatoma cells

Cited by 19 publications

References 58 publications

Hepatitis C Virus Seroprevalence and Associated Risk Factors Among Male Drug Injectors in Kermanshah, Iran

Hepatitis C Virus Seroprevalence and Associated Risk Factors Among Male Drug Injectors in Kermanshah, Iran

Hepatitis C Virus Manipulates Humans as its Favorite Host for a Long‐Term Relationship

Impact of the host environment on the antitubercular action of pyrazinamide

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