2008
DOI: 10.1074/jbc.m804788200
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Abstract: Lung cancer is the leading cause of cancer-related deaths both in men and women in the United States, with an incidence of ϳ213,000 new cases/year (1). Approximately 80% of lung cancers are classified histopathologically as non-small cell lung cancers. At early stages of non-small cell lung cancer, the only treatment is surgery, with a 5-year overall survival rate of 40% (2), whereas chemotherapy is mostly employed for small cell lung cancer. The majority of patients have developed an aggressive form of the di… Show more

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Cited by 324 publications
(153 citation statements)
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“…The decrease in intensity of DNA and protein features is consistent with the onset of apoptosis, which in turn is consistent with a DOX mechanism of action by induction of cell apoptosis, consisting of programmed and intrinsic cell death, DNA fragmentation, membrane blebbing and consequently interrupted cancer cell growth. 48,53,54 In the case of the cytoplasm, a similar spectrum is obtained before and after exposure to DOX, although subtle changes of some of the spectral features are apparent (indicated by grey shaded regions in Fig. 4C), such as a decrease in the 720 cm −1 Fig.…”
Section: Raman Micro Spectroscopymentioning
confidence: 73%
See 1 more Smart Citation
“…The decrease in intensity of DNA and protein features is consistent with the onset of apoptosis, which in turn is consistent with a DOX mechanism of action by induction of cell apoptosis, consisting of programmed and intrinsic cell death, DNA fragmentation, membrane blebbing and consequently interrupted cancer cell growth. 48,53,54 In the case of the cytoplasm, a similar spectrum is obtained before and after exposure to DOX, although subtle changes of some of the spectral features are apparent (indicated by grey shaded regions in Fig. 4C), such as a decrease in the 720 cm −1 Fig.…”
Section: Raman Micro Spectroscopymentioning
confidence: 73%
“…33 It is also notable that fragmentation of nucleoli within the nucleus is observed upon DOX treatment for 24 h, confirming that cells are going under apoptosis. 48 …”
Section: Confocal Laser Scanning Fluorescence Microscopymentioning
confidence: 99%
“…Cell Proliferation Assay-Cell proliferation was monitored using cell proliferation reagent kit I (MTT) (Roche Applied Science) as described before (23). All of the experiments were performed in quadruplicate.…”
Section: Methodsmentioning
confidence: 99%
“…TaqMan RT-PCR for Quantification of miR-122-RNA was isolated from FFP tissue sections as described (23). An aliquot (100 ng) of total RNA was treated with DNase I (2 units) at 37°C for 15 min followed by heat inactivation of DNase I at 65°C for 5 min.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation