Down-regulating Circular RNA Prkcsh suppresses the inflammatory response after spinal cord injury

Chen, Jianan; Zhang, Yining; Tian, Lijie; Zhang, Ying; Li, Xinyu; Ning, Bin

doi:10.4103/1673-5374.314114

Cited by 20 publications

(4 citation statements)

References 49 publications

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“…In this review, the lncRNA/circRNA-miRNA-mRNA regulatory network also exists in microglia and astrocyte mediated neurological diseases, including SCI (Figure 1; Shao et al, 2020; FIGURE 1 | The lncRNA/circRNA-miRNA-mRNA regulatory network in microglia and astrocyte regulated neurological diseases. Xu S. et al, 2020;Zhao Q. et al, 2020;Cui et al, 2021;Xiang et al, 2021;Chen et al, 2022), TBI (He et al, 2021;Liu N. et al, 2021;Meng et al, 2021), cerebral IRI (Figure 1; Wang et al, 2020c;Yang et al, 2021), stroke (Figure 1; Qi et al, 2017;Han B. et al, 2018;Tian et al, 2021;Zhang M. et al, 2021), epilepsy (Figure 1; Feng et al, 2020;Han C. L. et al, 2020;Wan and Yang, 2020;Xiaoying et al, 2020), neuropathic pain (Figure 1; Chen M. et al, 2020), PD (Figure 1; Cao et al, 2018Cao et al, , 2021, and depression (Figure 1; . We also found that some therapies can impair the ncRNA-glial cell axis and thus inhibit disease development.…”

Section: Discussionmentioning

confidence: 99%

“…Elevated miR-488 attenuates inflammatory cytokine secretion in TNF-αtreated astrocytes. Chemokine CC motif ligand 2 (CCL2) is a downstream target of miR-488 (Chen et al, 2022). CircPrkcsh is up-regulated in mouse injured spinal cords and in TNF-α-treated astrocytes.…”

Section: Circular Rnas In Microglia and Astrocyte Mediated Neurological Diseases Spinal Cord Injurymentioning

confidence: 99%

“…CircPrkcsh serves as a miRNA sponge for miR-488. Silencing circPrkcsh decreases CCL2 expression via miR-488 upregulation (Chen et al, 2022). Chen et al (2022) revealed that circPrkcsh knockout represses inflammatory response after SCI through the miR-488-CCL2 axis.…”

Section: Circular Rnas In Microglia and Astrocyte Mediated Neurological Diseases Spinal Cord Injurymentioning

confidence: 99%

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Long Non-coding RNAs and Circular RNAs: Insights Into Microglia and Astrocyte Mediated Neurological Diseases

Chen

Lai

Wang

et al. 2021

Front. Mol. Neurosci.

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Microglia and astrocytes maintain tissue homeostasis in the nervous system. Both microglia and astrocytes have pro-inflammatory phenotype and anti-inflammatory phenotype. Activated microglia and activated astrocytes can contribute to several neurological diseases. Long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), two groups of non-coding RNAs (ncRNAs), can function as competing endogenous RNAs (ceRNAs) to impair the microRNA (miRNA) inhibition on targeted messenger RNAs (mRNAs). LncRNAs and circRNAs are involved in various neurological disorders. In this review, we summarized that lncRNAs and circRNAs participate in microglia dysfunction, astrocyte dysfunction, neuron damage, and inflammation. Thereby, lncRNAs and circRNAs can positively or negatively regulate neurological diseases, including spinal cord injury (SCI), traumatic brain injury (TBI), ischemia-reperfusion injury (IRI), stroke, neuropathic pain, epilepsy, Parkinson’s disease (PD), multiple sclerosis (MS), and Alzheimer’s disease (AD). Besides, we also found a lncRNA/circRNA-miRNA-mRNA regulatory network in microglia and astrocyte mediated neurological diseases. Through this review, we hope to cast light on the regulatory mechanisms of lncRNAs and circRNAs in microglia and astrocyte mediated neurological diseases and provide new insights for neurological disease treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Circular Rnas In Microglia and Astrocyte Mediated Neurological Diseases Spinal Cord Injurymentioning

confidence: 99%

Section: Circular Rnas In Microglia and Astrocyte Mediated Neurological Diseases Spinal Cord Injurymentioning

confidence: 99%

See 1 more Smart Citation

Long Non-coding RNAs and Circular RNAs: Insights Into Microglia and Astrocyte Mediated Neurological Diseases

Chen

Lai

Wang

et al. 2021

Front. Mol. Neurosci.

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“…Total RNA was extracted with the TRIzol method, and cDNA was synthesized by the EvoM‐MLV Reverse Transcription Premix Kit (Accurate Biology AG, Hunan, China). ( 24 ) qRT‐PCR was performed using the SYBR® GreenProTaqHS premixed qRT‐PCR kit (Accurate Biology AG), and reactions were performed on a quantitative fluorescence qRT‐PCR system (LightCycler460I, Roche, Basel, Switzerland). The mRNA expression levels of target genes were calculated by ΔΔCT, and fold changes of mRNA levels were normalized to GAPDH.…”

Section: Methodsmentioning

confidence: 99%

Higenamine Promotes Osteogenesis Via IQGAP1/SMAD4 Signaling Pathway and Prevents Age- and Estrogen-Dependent Bone Loss in Mice

Dong

Liu

Zou

et al. 2020

Journal of Bone and Mineral Research

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Osteoporosis is a common bone disease caused by an imbalance of bone resorption and formation that results in a loss of total bone density. SMAD2/3 signal transduction is known to play a crucial role in osteogenic differentiation through transforming growth factor-beta (TGF-β). By screening a library of small-molecule compounds, the current study identifies higenamine (HG) as an active osteogenic agent that could be a therapeutic candidate for osteoporosis. In vitro data demonstrated that HG effectively induced expressions of osteogenic markers in mouse bone marrow stromal cell (BMSCs) and preosteoblastic cell cultures. Further, HG treatment resulted in enhanced bone formation and prevented accelerated bone loss on two animal models that mimic spontaneous senile osteoporosis and postmenopausal osteoporosis. IQ motif-containing GTPase-activating protein 1 (IQGAP1) was confirmed as a novel target of HG, where HG appears to bind to the Glu-1019 site of IQGAP1 to exert its osteogenic effects. Data subsequently suggested that HG promoted phosphorylation of SMAD2/3 and regulated the SMAD2/3 pathway by inhibiting SMAD4 ubiquitination. Overall, the findings highlight HG as a new small-molecule drug to promote bone formation through SMAD2/3 pathway in osteoporosis.

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circ-Ncam2 (mmu_circ_0006413) Participates in LPS-Induced Microglia Activation and Neuronal Apoptosis via the TLR4/NF-κB Pathway

et al. 2022

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Down-regulating Circular RNA Prkcsh suppresses the inflammatory response after spinal cord injury

Cited by 20 publications

References 49 publications

Long Non-coding RNAs and Circular RNAs: Insights Into Microglia and Astrocyte Mediated Neurological Diseases

Long Non-coding RNAs and Circular RNAs: Insights Into Microglia and Astrocyte Mediated Neurological Diseases

Higenamine Promotes Osteogenesis Via IQGAP1/SMAD4 Signaling Pathway and Prevents Age- and Estrogen-Dependent Bone Loss in Mice

circ-Ncam2 (mmu_circ_0006413) Participates in LPS-Induced Microglia Activation and Neuronal Apoptosis via the TLR4/NF-κB Pathway

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