Double trouble: Influenza and pneumococcal vaccine exacerbation of psoriasis in a new‐onset polycythemia vera patient

Abstract

counts and CRP level. A low birthweight baby with no anomalies was born at 36 gestational weeks (Apgar score, 8). After remission, adalimumab was administrated by self-injection instead of CZP. The CZP level was 95.4-40.1 pg/mL in the patient's serum at indicated time points (Fig. 1), which reduced to 21.5 pg/mL 3 weeks after the last CZP injection; CZP was not detected 7 weeks after its last injection. CZP was not detected in the umbilical cord serum at the time of delivery and in the baby's serum at 4 and 6 weeks post-birth. Increased risks of intrauterine growth restriction and miscarriage have been reported in GPP cases during pregnancy. 1 Thus, the control of GPP before and during pregnancy is important for the fetal condition. Anti-tumor necrosis factor (TNF)-a agents are more beneficial for psoriatic disease control during pregnancy than interleukin (IL)-12/23 or IL-17 inhibitors because of their available accumulated long-term data. CZP is a pegylated Fab 0 fragment of a humanized TNF-a monoclonal antibody. Because no placental transportability has been reported in patients with rheumatoid arthritis, 4,5 we determined the serum CZP concentration of a GPP patient during pregnancy. CZP was not detected in umbilical cord serum or in the baby's serum, which indicates no placental transportability of CZP in the present case

New onset and exacerbation of psoriasis after COVID-19 vaccination

“…Previous studies have reported influenza (H1N1), tetanus-diphtheria, BCG, and pneumococcal pneumonia vaccination as a triggering factor for newonset or flare of psoriasis. [4][5][6][7][8][9][10][11][12] To date, there is 1 published case report describing a psoriasis flare-up 5 days after the second dose of the Pfizer-BioNTech vaccine. 13 Potential cutaneous adverse events following COVID-19 vaccination were described in a registry-based study of 414 cases and included delayed large local reactions, local injection-site reactions, urticarial eruptions, morbilliform reactions, pernio, cosmetic filler reactions, herpes zoster, herpes simplex flares, and pityriasis rosea-like reactions.…”

“…While uncommon, a potential association has previously been documented between new onset or exacerbation of psoriasis in response to vaccination against Bacillus Calmette-Gu erin (BCG), influenza, tetanus-diphtheria, and pneumococcal polysaccharide. [4][5][6][7][8][9][10][11][12] This response has been documented in inactivated, attenuated, toxoid, and polysaccharide types of vaccines but not in the novel mRNA vaccine clinical trial data.…”

Psoriasis flare after influenza vaccination in Covid‐19 era: A report of four cases from a single center

“…The first patient was a 41-year-old man with chronic plaque psoria- vaccinalis" has also been described with Bacillus Calmette-Guerin, tetanus-diphtheria, and pneumococcal polysaccharide vaccines, including psoriasis-like eruptions and psoriatic arthropathy. [8][9][10][11] The very low incidence of this condition and the favorable costeffectiveness of the influenza vaccine should not change the immunization practice, especially for patients with psoriasis undergoing immunosuppressive and/or biological therapy. 5,6 Nevertheless, it is important to acknowledge vaccination as a triggering factor of psoriasis flare-ups, particularly in the COVID-19 era, given that we do not yet know whether COVID-19 vaccines will be a triggering factor for preexisting or new dermatological conditions, although it appears possible.…”

New onset of remitting seronegative symmetrical synovitis with pitting oedema and palmoplantar psoriasis flare‐up after Sars‐Cov‐2 vaccination

“…To date, the cases of psoriasis flare-up have been described with influenza, pneumococcal polysaccharide, Bacillus Calmette-Guerin (BCG) and tetanus-diphtheria vaccines. [1][2][3] In this case, the close temporal link between Sars-Cov-2 vaccination and the onset of psoriasis flare-up associated with joint involvement suggests a possible causal association between the two events.…”