Double sentinel lymph node mapping with indocyanine green and 99m-technetium–tin colloid in oral squamous cell carcinoma

Murase, Ryuichi; Tanaka, Hiroshi; Hamakawa, Tomohiro; Goda, Hiroyuki; Tano, Tomoyuki; Ishikawa, Akiko; Hino, Shinjiro; Sumida, Tomoki; Nakashiro, Koh‐ichi; Hamakawa, Hiroyuki

doi:10.1016/j.ijom.2015.05.008

Cited by 24 publications

(23 citation statements)

References 26 publications

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“…Indocyanine green (ICG) has been utilized for fluorescent guidance in sentinel lymph node dissections of OSCC patients by injection of the agent at the primary site . However, ICG does not show effective tissue specificity at the primary site to be useful as a tool for intraoperative margin delineation …”

Section: Resultsmentioning

confidence: 99%

Surgical margins in oral cavity squamous cell carcinoma: Current practices and future directions

et al. 2019

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Objective: To discuss the current available techniques for intraoperative margin assessment in the surgical treatment of oral squamous cell carcinoma (OSCC) through a review of the available literature.Methods: A systematic review was undertaken of the available English literature between 2008 through 2018 regarding surgical margins in OCSS. A total of 893 relevant articles were returned; 144 met criteria for review; and 64 articles were included.Results: In this review, we discuss the data surrounding the use of frozen section in OCSS. Additionally, alternative techniques for margin assessment are discussed, including Mohs, molecular analysis, nonfluorescent dyes, fluorescent dyes, autofluorescent imaging, narrow-band imaging, optical coherence tomography, confocal microscopy, high-resolution microendoscopy, and spectroscopy. For each technique, particular emphasis is placed on the local recurrence, disease-free survival, and overall survival rates when available.Conclusion: This review provides support for the practice of specimen-driven margin assessment when using frozen section analysis to improve the utility of the results. Finally, several alternatives for intraoperative margin assessment currently under investigation, including pathologic, wide-field imaging and narrow-field imaging techniques, are presented. We aim to fuel further investigation into methods for margin assessment that will improve survival for patients with OSCC through a critical analysis of the available techniques.

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Section: Resultsmentioning

confidence: 99%

Surgical margins in oral cavity squamous cell carcinoma: Current practices and future directions

et al. 2019

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“…Hybrid gamma–NIR fluorescence intraoperative guidance has been used for breast [ 31 ], prostate [ 32 , 33 ], vulvar [ 34 , 35 ] and penile [ 36 – 39 ] cancers along with a range of melanomas [ 36 , 40 – 42 ] and cancers of the head and neck (H&N) [ 36 , 38 , 40 – 45 ]. Figure 2 provides an example series of images from a head and neck procedure.…”

Section: Resultsmentioning

confidence: 99%

“…All the studies in Table 4 found some utility in the hybrid approach. Nine papers described nodes detectable with NIR imaging but not with the gamma probe [ 33 , 36 , 37 , 39 , 40 , 42 – 45 ], and seven described nodes detectable with the gamma probe but not NIR imaging [ 33 , 34 , 36 , 37 , 39 , 40 , 43 ] (six studies describe both situations [ 33 , 36 , 37 , 39 , 40 , 43 ]). A number of authors stated that the blue dye typically used for SLNB did not provide additional benefits for detection over the dual use of 99m Tc and ICG [ 31 , 34 , 35 , 37 , 40 , 42 ].…”

Section: Resultsmentioning

confidence: 99%

Hybrid intraoperative imaging techniques in radioguided surgery: present clinical applications and future outlook

Bugby

Lees

Perkins

2017

Clin Transl Imaging

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PurposeThis review aims to summarise the hybrid modality radioguidance techniques currently in clinical use and development, and to discuss possible future avenues of research. Due to the novelty of these approaches, evidence of their clinical relevance does not yet exist. The purpose of this review is to inform nuclear medicine practitioners of current cutting edge research in radioguided surgery which may enter standard clinical practice within the next 5–10 years. Hybrid imaging is of growing importance to nuclear medicine diagnostics, but it is only with recent advances in technology that hybrid modalities are being investigated for use during radioguided surgery. These modalities aim to overcome some of the difficulties of surgical imaging while maintaining many benefits, or providing entirely new information unavailable to surgeons with traditional radioguidance.MethodsA literature review was carried out using online reference databases (Scopus, PubMed). Review articles obtained using this technique were citation mined to obtain further references.ResultsIn total, 2367 papers were returned, with 425 suitable for further assessment. 60 papers directly related to hybrid intraoperative imaging in radioguided surgery are reported on. Of these papers, 25 described the clinical use of hybrid imaging, 22 described the development of new hybrid probes and tracers, and 13 described the development of hybrid technologies for future clinical use. Hybrid gamma–NIR fluorescence was found to be the most common clinical technique, with 35 papers associated with these modalities. Other hybrid combinations include gamma–bright field imaging, gamma–ultrasound imaging, gamma–β imaging and β–OCT imaging. The combination of preoperative and intraoperative images is also discussed.ConclusionHybrid imaging offers new possibilities for assisting clinicians and surgeons in localising the site of uptake in procedures such as in sentinel node detection.

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“…With a 20-30% incidence of lymph node metastases, the cervical lymph node status is the key prognostic factor (1,2). To be risk adverse, elective neck dissections are commonly performed in clinically N0 patients, but have associated morbidity and risks, especially in pathologically N0 patients (3). Attention has been focused on sentinel node navigation surgery to improve diagnostic accuracy with lower risks.…”

Section: Short Communicationmentioning

confidence: 99%

Furthering Precision in Sentinel Node Navigational Surgery for Oral Cancer: a Novel Triple Targeting System

et al. 2018

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Purpose: To describe an innovative sentinel lymph node (SLN) guidance approach using a radionuclide tracer, 3D augmented reality-guided imaging, and near infrared (NIR) fluorescence overlay imaging with hand-held probes to optimize accuracy, efficiency, and precise navigation for sentinel node (SN) localization in head and neck cancer. Methods: In a cT1N0M0 squamous cell carcinoma of the tongue, pre-operative radionuclide lymphoscintigraphy was performed with a sentinel node-specific radiolabeled tracer. Intraoperatively, a 3D hand-held augmented reality (AR) scanning SPECT probe assessed concordance of the SN with pre-operative SPECT-CT images. The real-time optical video was linked to the SPECT-CT images for added precision. Final guidance to the SN was performed using ICG fluorescence imaging. Results: Dynamic and SPECT-CT showed bilateral lymphatic drainage from the tumor. The 3D hand-held AR SPECT probe SN localization was concordant with pre-operative imaging. The optical video successfully demonstrated the lymphatic drainage in realtime through a unique overlay fluorescence image. The ICG localized to the same nodes identified by both the SPECT-CT and hand-held SPECT images. The use of dual radiation and fluorescence tracers improved SN detection, especially for SN close to the injection site. The hand-held probes allowed the surgeon to dissect continuously, without needing to change tools. Conclusions: The combination of augmented reality, nuclear medicine, and overlay fluorescence imaging allowed greater accuracy for matching the preoperative imaging with intraoperative identification and precisely guiding the dissection. This method uniquely permitted the surgeon to efficiently dissect the SN with accurate visualization and optimal precision.

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Double sentinel lymph node mapping with indocyanine green and 99m-technetium–tin colloid in oral squamous cell carcinoma

Cited by 24 publications

References 26 publications

Surgical margins in oral cavity squamous cell carcinoma: Current practices and future directions

Surgical margins in oral cavity squamous cell carcinoma: Current practices and future directions

Hybrid intraoperative imaging techniques in radioguided surgery: present clinical applications and future outlook

Furthering Precision in Sentinel Node Navigational Surgery for Oral Cancer: a Novel Triple Targeting System

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