Double-masked prospective ocular safety study of a lens epithelial cell antibody to prevent posterior capsule opacification

Abstract

This prospective, randomized, placebo-controlled trial confirmed that MDX-RA is safe for intraocular use and is of potential value for further clinical trials of the prevention of PCO.

Effect of lens epithelial cell aspiration on postoperative capsulorhexis contraction with the use of the AcrySof intraocular lens

“…Pharmacological methods such as immunoconjugates have been used in small clinical studies without obvious side effects, 21 and in vitro studies have examined antimigration drugs to minimize the effect of residual LECs. 22 None is available for widespread use in ophthalmology.…”

Ribosome-inactivating proteins: progress and problems

“…Other possible uses of immunotoxins in ophthalmology have been explored, for the treatment of posterior capsule opacification, for which some clinical trials have been performed [184,196], and to prevent corneal cell proliferation [197]. A number of interesting results were obtained with the use of saporin-containing immunotoxins and other conjugates directed against a variety of nervous cells.…”

Lens epithelial cells in an in vitro capsular bag model: Lens-in-the-bag versus bag-in-the-lens technique

“…[4][5][6][7][8][9][10] Because of the great economic and functional burden of PCO, several surgical and nonsurgical strategies to prevent PCO have been proposed. These include the use of chemical substances and antibodies [11][12][13] ; hyperthermia 14 ; careful cleanup of the capsular bag 15,16 ; new IOL designs, coatings, and biomaterials [16][17][18][19][20][21][22][23] ; primary posterior continuous curvilinear capsulorhexis (PCCC) [24][25][26][27][28] ; and IOL capture or buttonholing. 29 The diversity of these recently developed therapeutical approaches relies on increased knowledge of the pathophysiology behind PCO, which is generally accepted to comprise 4 classic steps: (1) adhesion, (2) proliferation, (3) migration of the remaining LECs to the capsule, and (4) differentiation to myofibrotic cells.…”