Double dissociation of N1 and P3 abnormalities in deficit and nondeficit schizophrenia

N400 and P300 modulation as functions of processing level in schizophrenia patients exhibiting formal thought disorder

“…The interpretation of these results is a subject of controversy. On one hand, it has been proposed that auditory, and possibly visual, P300 amplitudes track fluctuations in clinical state (Mathalon et al, 2000;Wood et al, 2006;Mucci et al, 2007). However, we demonstrated in a previous paper (Laurent and Baribeau, 1992) that auditory P300 amplitude reduction is a trait marker in FTD but a state marker in non-FTD schizophrenics, and we have recently confirmed this finding in a new population of FTD patients.…”

Brain white matter microstructure in deficit and non-deficit subtypes of schizophrenia

“…Several studies have explored socio-demographic characteristics Messias et al, 2004), risk factors (Kirkpatrick et al, 2000a), clinical outcome (Carpenter, 1994;Tek et al, 2001), response to treatment (Kirkpatrick et al, 2000b) and neurobiological features Ross et al, 1997;Waltrip et al, 1997;Hong et al, 2005) associated with SZD. Some studies have demonstrated double dissociations (SZD patients impaired on measure A but not B; SZND patients impaired on measure B but not A) in metabolic measures (Garcia-Rizo et al, 2012), season of birth (Messias et al, 2004), and electrophysiological variables (Mucci et al, 2007). These studies are consistent with the concept that SDZ is a separate disorder within the syndrome of schizophrenia.…”

Dysfunctional Attitudes and Expectancies in Deficit Syndrome Schizophrenia

“…7 Yet, despite a worse prognosis, deficit patients experience less overall negative affect, 8 have a lower risk for suicide, 9 and abuse substances less than nondeficit patients. 10 Whereas neurobiological research has identified anomalies associated with the deficit syndrome in the areas of eye tracking, 11 olfaction, 12 event-related potentials, 13 and neuroanatomy, 14 these findings have not translated into improved treatments. In fact, the poor prognosis of deficit patients may be due, in large part, to their poor response to both psychotropic medications 15 and psychosocial interventions such as social skills training.…”