Double blind glucocorticoid controlled trial of samarium-153 particulate hydroxyapatite radiation synovectomy for chronic knee synovitis

Synovectomy with 153Samarium Hydroxyapatite in Haemophilic Arthropathy

“…No escape (lymphatic or vascular) was detected with 153-samarium because when it separates from the carrier (hydroxyapatite), it forms insoluble compounds with the synovial luid that precipitate in the articulation; this permanence was conirmed by other previous studies [20] and by our controls (see Figure 3). Scintigraphic images obtained after early and late-phase injection showed appropriate intra-articular distribution, as well as the absence of leakage to regional lymph nodes or other organs, or urinary elimination.…”

Cationic and Anionic Substitutions in Hydroxyapatite

“…In addition, recent studies reported the use of 153 Sm-hydroxyapatite particles as radiation synovectomy agents for the treatment of chronic synovitis [277][278][279], especially knee synovitis [277,278]. Moreover, 153 Sm-hydroxyapatite particles have to be considered as the best candidates for radiation synovectomy due to its shorter half-life and the lower extraarticular leakage of 153 Sm-hydroxyapatite [278].…”

Calcium orthophosphates (CaPO 4 ): Occurrence and properties

“…(Kim et al 1998;Kolmas et al 2014;Stanić et al 2010) and Cu 2? (Kim et al 1998;Kolmas et al 2014;Stanić et al 2010;Li et al 2010) was used for imparting antimicrobial effect, while radioactive isotopes of 90 Y (Thomas et al 2008), 153 Sm (Chinol et al 1993;Argüelles et al 1999;O'Duffy et al 1999) and 186 Re (Chinol et al 1993) were incorporated into HA bioceramics and injected into knee joints to treat rheumatoid joint synovitis (Thomas et al 2008;Chinol et al 1993;O'Duffy et al 1999). More to the point, apatites were found to incorporate individual molecules, such as water, oxygen and carbon dioxide (Rey et al 2006).…”