Double-blind comparison of meclofenamate sodium plus codeine, meclofenamate sodium, codeine, and placebo for relief of pain following surgical removal of third molars

Single dose oral codeine, as a single agent, for acute postoperative pain in adults

“…All included studies were both randomised and double blind. Six studies had a score of 3 using the Oxford Quality Scale (Bentley 1987; Defoort 1983; Honig 1984; Jain 1988; Sunshine 1988,van Steenberghe 1986), 9 a score of 4 (Baird 1980; Bloomfield 1981; Cooper 1982; Desjardins 1984; Giglio 1990; Hersh 1993;Mehlisch 1984; Sunshine 1987; Yonkeura 1987), and 20 a score of 5 (Forbes 1986; Hebertson 1986; Moore 1997 (17 studies);Sunshine 1983). Points were mainly lost due to inadequate description of the methods of randomisation and double blinding.…”

“…Thirty-three studies (2411 participants) provided data (Baird 1980; Bentley 1987; Bloomfield 1981; Cooper 1982; Defoort 1983; Desjardins 1984; Forbes 1986; Giglio 1990; Hebertson 1986; Hersh 1993; Honig 1984; Jain 1988; Moore 1997 (17 studies); Sunshine 1983; Sunshine 1987; Sunshine 1988; Yonkeura 1987). One study (van Steenberghe 1986) did not provide data for this outcome.…”

Single dose oral codeine, as a single agent, for acute postoperative pain in adults

“…All included studies were both randomised and double blind. Six studies had a score of 3 using the Oxford Quality Scale (Bentley 1987; Defoort 1983; Honig 1984; Jain 1988; Sunshine 1988,van Steenberghe 1986), 9 a score of 4 (Baird 1980; Bloomfield 1981; Cooper 1982; Desjardins 1984; Giglio 1990; Hersh 1993;Mehlisch 1984; Sunshine 1987; Yonkeura 1987), and 20 a score of 5 (Forbes 1986; Hebertson 1986; Moore 1997 (17 studies);Sunshine 1983). Points were mainly lost due to inadequate description of the methods of randomisation and double blinding.…”

“…Thirty-three studies (2411 participants) provided data (Baird 1980; Bentley 1987; Bloomfield 1981; Cooper 1982; Defoort 1983; Desjardins 1984; Forbes 1986; Giglio 1990; Hebertson 1986; Hersh 1993; Honig 1984; Jain 1988; Moore 1997 (17 studies); Sunshine 1983; Sunshine 1987; Sunshine 1988; Yonkeura 1987). One study (van Steenberghe 1986) did not provide data for this outcome.…”

Managing postoperative pain in adult outpatients: a systematic review and meta-analysis comparing codeine with NSAIDs

“…Desjardins et al, 1984 36 Daniels et al, 2011 33 Forbes et al, 1990 41 Habib et al, 1990 47 Forbes et al, 1986 39 Comfort et al, 2002 27 Gatoulis et al, 2012 43 Dionne et al, 1994 37 Giglio et al, 1990 44 Cooper et al, 1991 30 Giles et al, 1986 46 Daniels et al, 2011 34 Vargas Busquets et al, 1998 62 Mehlisch et al, 1984 53 Coutinho et al, 1976 32 Forbes et al, 1989 40 Hersh et al, 1993 48 Coutinho et al, 1976 32 Daniels et al, 2011 33 Sniezek et al, 2011 59 De Los Santos et al, 1998 35 Cooper et al, 1991 30 Forbes et al, 1990 42 Chang et al, 2001 25 Giles et al, 1985 45 Forbes et al, 1982 38 Cooper et al, 1993 31…”

Resolving Issues About Efficacy and Safety of Low-Dose Codeine in Combination Analgesic Drugs: A Systematic Review

“…Efficacy of low-dose codeine combination medicinal products was analysed through review of 16 placebo-controlled studies which involved 3378 subjects. Most of the studies were focused on codeine combination efficacy regarding surgery pain with most of them relating to the dental surgery pain (9 out of the total 16 studies) [15][16][17][18][19][20][21][22][23]; two were focused on tension headache [20,24]; one on acute migraine attack [25]; one on post-episiotomy pain [26]; one on post-orthopaedic surgery pain [27]; one on post-photorefractive keratectomy pain [28]; and one on post-operative pain [29].…”

“…Medicinal products as found in the aforementioned studies contained the following 9 substances alongside codeine: paracetamolnine studies [10, 16-18, 20, 25, 27-29]; acetylsalicylic acid-seven studies [15,[17][18][19][22][23][24][25]; and ibuprofen-six studies [16, 19, 22, 23 26, 27]; followed by butalbital-three studies [16,17,24]; caffeine-three studies [16,17,24]; zomepirac-one study [24]; meclofenam-one study [21]; pentazocine-one study [29]; and propoxyphene napsylate-one study [29].…”

Single dose oral codeine, as a single agent, for acute postoperative pain in adults

“…All included studies were both randomised and double blind. Six studies had a score of 3 using the Oxford Quality Scale (Bentley 1987; Defoort 1983; Honig 1984; Jain 1988; Sunshine 1988,van Steenberghe 1986), 9 a score of 4 (Baird 1980; Bloomfield 1981; Cooper 1982; Desjardins 1984; Giglio 1990; Hersh 1993;Mehlisch 1984; Sunshine 1987; Yonkeura 1987), and 20 a score of 5 (Forbes 1986; Hebertson 1986; Moore 1997 (17 studies);Sunshine 1983). Points were mainly lost due to inadequate description of the methods of randomisation and double blinding.…”

“…Thirty-three studies (2411 participants) provided data (Baird 1980; Bentley 1987; Bloomfield 1981; Cooper 1982; Defoort 1983; Desjardins 1984; Forbes 1986; Giglio 1990; Hebertson 1986; Hersh 1993; Honig 1984; Jain 1988; Moore 1997 (17 studies); Sunshine 1983; Sunshine 1987; Sunshine 1988; Yonkeura 1987). One study (van Steenberghe 1986) did not provide data for this outcome.…”

Managing postoperative pain in adult outpatients: a systematic review and meta-analysis comparing codeine with NSAIDs

“…Desjardins et al, 1984 36 Daniels et al, 2011 33 Forbes et al, 1990 41 Habib et al, 1990 47 Forbes et al, 1986 39 Comfort et al, 2002 27 Gatoulis et al, 2012 43 Dionne et al, 1994 37 Giglio et al, 1990 44 Cooper et al, 1991 30 Giles et al, 1986 46 Daniels et al, 2011 34 Vargas Busquets et al, 1998 62 Mehlisch et al, 1984 53 Coutinho et al, 1976 32 Forbes et al, 1989 40 Hersh et al, 1993 48 Coutinho et al, 1976 32 Daniels et al, 2011 33 Sniezek et al, 2011 59 De Los Santos et al, 1998 35 Cooper et al, 1991 30 Forbes et al, 1990 42 Chang et al, 2001 25 Giles et al, 1985 45 Forbes et al, 1982 38 Cooper et al, 1993 31…”

Resolving Issues About Efficacy and Safety of Low-Dose Codeine in Combination Analgesic Drugs: A Systematic Review

“…Efficacy of low-dose codeine combination medicinal products was analysed through review of 16 placebo-controlled studies which involved 3378 subjects. Most of the studies were focused on codeine combination efficacy regarding surgery pain with most of them relating to the dental surgery pain (9 out of the total 16 studies) [15][16][17][18][19][20][21][22][23]; two were focused on tension headache [20,24]; one on acute migraine attack [25]; one on post-episiotomy pain [26]; one on post-orthopaedic surgery pain [27]; one on post-photorefractive keratectomy pain [28]; and one on post-operative pain [29].…”

“…Medicinal products as found in the aforementioned studies contained the following 9 substances alongside codeine: paracetamolnine studies [10, 16-18, 20, 25, 27-29]; acetylsalicylic acid-seven studies [15,[17][18][19][22][23][24][25]; and ibuprofen-six studies [16, 19, 22, 23 26, 27]; followed by butalbital-three studies [16,17,24]; caffeine-three studies [16,17,24]; zomepirac-one study [24]; meclofenam-one study [21]; pentazocine-one study [29]; and propoxyphene napsylate-one study [29].…”

Single dose oral codeine, as a single agent, for acute postoperative pain in adults

“…All included studies were both randomised and double blind. Six studies had a score of 3 using the Oxford Quality Scale (Bentley 1987; Defoort 1983; Honig 1984; Jain 1988; Sunshine 1988,van Steenberghe 1986), 9 a score of 4 (Baird 1980; Bloomfield 1981; Cooper 1982; Desjardins 1984; Giglio 1990; Hersh 1993;Mehlisch 1984; Sunshine 1987; Yonkeura 1987), and 20 a score of 5 (Forbes 1986; Hebertson 1986; Moore 1997 (17 studies);Sunshine 1983). Points were mainly lost due to inadequate description of the methods of randomisation and double blinding.…”

“…Thirty-three studies (2411 participants) provided data (Baird 1980; Bentley 1987; Bloomfield 1981; Cooper 1982; Defoort 1983; Desjardins 1984; Forbes 1986; Giglio 1990; Hebertson 1986; Hersh 1993; Honig 1984; Jain 1988; Moore 1997 (17 studies); Sunshine 1983; Sunshine 1987; Sunshine 1988; Yonkeura 1987). One study (van Steenberghe 1986) did not provide data for this outcome.…”

Managing postoperative pain in adult outpatients: a systematic review and meta-analysis comparing codeine with NSAIDs

“…Desjardins et al, 1984 36 Daniels et al, 2011 33 Forbes et al, 1990 41 Habib et al, 1990 47 Forbes et al, 1986 39 Comfort et al, 2002 27 Gatoulis et al, 2012 43 Dionne et al, 1994 37 Giglio et al, 1990 44 Cooper et al, 1991 30 Giles et al, 1986 46 Daniels et al, 2011 34 Vargas Busquets et al, 1998 62 Mehlisch et al, 1984 53 Coutinho et al, 1976 32 Forbes et al, 1989 40 Hersh et al, 1993 48 Coutinho et al, 1976 32 Daniels et al, 2011 33 Sniezek et al, 2011 59 De Los Santos et al, 1998 35 Cooper et al, 1991 30 Forbes et al, 1990 42 Chang et al, 2001 25 Giles et al, 1985 45 Forbes et al, 1982 38 Cooper et al, 1993 31…”

Resolving Issues About Efficacy and Safety of Low-Dose Codeine in Combination Analgesic Drugs: A Systematic Review

“…Efficacy of low-dose codeine combination medicinal products was analysed through review of 16 placebo-controlled studies which involved 3378 subjects. Most of the studies were focused on codeine combination efficacy regarding surgery pain with most of them relating to the dental surgery pain (9 out of the total 16 studies) [15][16][17][18][19][20][21][22][23]; two were focused on tension headache [20,24]; one on acute migraine attack [25]; one on post-episiotomy pain [26]; one on post-orthopaedic surgery pain [27]; one on post-photorefractive keratectomy pain [28]; and one on post-operative pain [29].…”

“…Medicinal products as found in the aforementioned studies contained the following 9 substances alongside codeine: paracetamolnine studies [10, 16-18, 20, 25, 27-29]; acetylsalicylic acid-seven studies [15,[17][18][19][22][23][24][25]; and ibuprofen-six studies [16, 19, 22, 23 26, 27]; followed by butalbital-three studies [16,17,24]; caffeine-three studies [16,17,24]; zomepirac-one study [24]; meclofenam-one study [21]; pentazocine-one study [29]; and propoxyphene napsylate-one study [29].…”