Dosimetry of laser-accelerated electron beams used for in vitro cell irradiation experiments

Richter, Christian; Kaluza, Malte C.; Karsch, L.; Schlenvoigt, Hans-Peter; Schürer, Michael; Sobiella, M.; Woithe, Julia; Pawelke, Jörg

doi:10.1016/j.radmeas.2011.04.019

Cited by 17 publications

(11 citation statements)

References 19 publications

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“…Richter (Richter et al 2011) presented dosimetry studies of low energy LWFA electrons (energy ranges corresponding to clinical LINACs). Lundh (Lundh et al 2012) conducted a study of 120 MeV LWFA electron beams.…”

Section: Phys Med Biol 59 (2014) 5811mentioning

confidence: 99%

Dosimetry of very high energy electrons (VHEE) for radiotherapy applications: using radiochromic film measurements and Monte Carlo simulations

Subiel¹,

Moskvin²,

Welsh³

et al. 2014

Phys. Med. Biol.

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Very high energy electrons (VHEE) in the range from 100-250 MeV have the potential of becoming an alternative modality in radiotherapy because of their improved dosimetry properties compared with MV photons from contemporary medical linear accelerators. Due to the need for accurate dosimetry of small field size VHEE beams we have performed dose measurements using EBT2 Gafchromic® film. Calibration of the film has been carried out for beams of two different energy ranges: 20 MeV and 165 MeV from conventional radio frequency linear accelerators. In addition, EBT2 film has been used for dose measurements with 135 MeV electron beams produced by a laser-plasma wakefield accelerator. The dose response measurements and percentage depth dose profiles have been compared with calculations carried out using the general-purpose FLUKA Monte Carlo (MC) radiation transport code. The impact of induced radioactivity on film response for VHEEs has been evaluated using the MC simulations. A neutron yield of the order of 10 −5 neutrons cm −2 per incident electron has been estimated and induced activity due to radionuclide production is found to have a negligible effect on total dose deposition and film response. Neutron and proton contribution to the equivalent doses are negligible for VHEE. The study demonstrates that EBT2 Gafchromic film is a reliable dosimeter that can be used for dosimetry of VHEE. The results indicate an energy-independent response of the dosimeter for 20 MeV and 165 MeV electron beams and has been found to be suitable for dosimetry of VHEE.

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Section: Phys Med Biol 59 (2014) 5811mentioning

confidence: 99%

Dosimetry of very high energy electrons (VHEE) for radiotherapy applications: using radiochromic film measurements and Monte Carlo simulations

Subiel¹,

Moskvin²,

Welsh³

et al. 2014

Phys. Med. Biol.

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“…Mostly, linacs providing lower-energy (∼4-25 MeV) electron beams are currently being used for the treatment of superficial cancer cells [23], and it has been suggested that, for tumors at larger depths inside the body, very-high-energy electron beams (VHEEs) of ∼150-250 MeV would be appropriate [24][25][26]. In this regard, Monte Carlo simulations have been performed for electron beam parameters generated from the LPA [11,12,[27][28][29][30]. Furthermore, in addition to the several other advantages described above, the LPA has also the advantage of ease and control of dose delivery.…”

Section: Introductionmentioning

confidence: 99%

Electron radiography with different beam parameters using laser plasma accelerator

Hazra

Mishra

Moorti

et al. 2019

Phys. Rev. Accel. Beams

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An experimental study on the radiography of various metallic and biological plant samples with a minimum resolution of ∼75 μm using relativistic electron beams from the laser plasma accelerator is presented. Electron beams were generated from the interaction of Ti:sapphire laser pulses of 120 fs duration with underdense plasma of 4 mm length, created using Ar and He gas jets, with two different parameters, i.e., a maximum energy of ∼50 MeV (broad spectrum) and a quasimonoenergetic beam with a peak energy of ∼150 MeV. GEANT4 Monte Carlo simulations were performed to reconstruct the radiographic images and were found to be consistent with the experimental results. Radiography of biological plant samples was also performed, and in this regard penetration depths of two types of electron beams in adipose tissue were estimated through a simulation. The effect of different electron beam parameters on the quality of the radiograph has been discussed.

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“…Crowell et al (2004) as well as Brozek-Pluskab et al (2005) have applied LWFA electrons to ultrafast radiolysis. Richter et al (2011) have irradiated LWFA created electrons on in vitro cells. X-rays emitted by betatron oscillations in LWFA (Corde and Phuoc 2013; Albert and Anderson 2010; Farinella and Lau 2016) may be also employed for diagnosis such as phase contrast imaging Fig.…”

Section: The Future Directionsmentioning

confidence: 99%

Wakefield acceleration

Tajima

Yan

Ebisuzaki

2020

Rev. Mod. Plasma Phys.

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The fundamental idea of Laser Wakefield Acceleration (LWFA) is reviewed. An ultrafast intense laser pulse drives coherent wakefields of relativistic amplitude with the high phase velocity robustly supported by the plasma. The structures of wakes and sheaths in plasma are contrasted. While the large amplitude of wakefields involves collective resonant oscillations of the eigenmode of the entire plasma electrons, the wake phase velocity ~ c and ultrafastness of the laser pulse introduce the wake stability and rigidity. When the phase velocity gets smaller, wakefields turn into sheaths. When we deploy laser ion acceleration or high density LWFA in which the phase velocity of plasma excitation is low, we encounter the sheath dynamics. A large number of worldwide experiments show a rapid progress of this concept realization toward both the high energy accelerator prospect and broad applications. The strong interest in this has driven novel laser technologies, including the Chirped Pulse Amplification, the Thin Film Compression (TFC), the Coherent Amplification Network, and the Relativistic Compression (RC). These in turn have created a conglomerate of novel science and technology with LWFA to form a new genre of high field science with many parameters of merit in this field increasing exponentially lately. Applications such as ion acceleration, X-ray free electron laser, electron and ion cancer therapy are discussed. A new avenue of LWFA using nanomaterials is also emerging, adopting X-ray laser using the above TFC and RC. Meanwhile, we find evidence that the Mother Nature spontaneously created wakefields that accelerate electrons and ions to very high energies.

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Dosimetry of laser-accelerated electron beams used for in vitro cell irradiation experiments

Cited by 17 publications

References 19 publications

Dosimetry of very high energy electrons (VHEE) for radiotherapy applications: using radiochromic film measurements and Monte Carlo simulations

Dosimetry of very high energy electrons (VHEE) for radiotherapy applications: using radiochromic film measurements and Monte Carlo simulations

Electron radiography with different beam parameters using laser plasma accelerator

Wakefield acceleration

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