Dosimetric comparison of volumetric modulated arc therapy (VMAT) and high-dose-rate brachytherapy (HDR-BT) for superficial skin irradiation with significant curvature in one or more planes

Wills, Rachel; Lowe, Gerry; Jones, Caroline L.; Hoskin, Peter

doi:10.1007/s00066-021-01759-4

Cited by 4 publications

(6 citation statements)

References 26 publications

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“…Critical organs at risk can be shielded using multi‐leaf collimators and steep dose gradients without compromising the coverage of the planning target volume. 9 Incomplete resections or mutilating surgery of cSCC in the face are not justified because cSCC are highly radiosensitive tumors. 1 Even large tumors can be cured with definitive radiotherapy.…”

Section: Discussionmentioning

confidence: 99%

“…Pretreatment imaging and VMAT allow high‐precision delivery of radiotherapy to the tumor while sparing normal tissue. Critical organs at risk can be shielded using multi‐leaf collimators and steep dose gradients without compromising the coverage of the planning target volume 9 . Incomplete resections or mutilating surgery of cSCC in the face are not justified because cSCC are highly radiosensitive tumors 1 .…”

Section: Discussionmentioning

confidence: 99%

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Noninvasive treatment of two deeply invasive cutaneous squamous cell carcinomas of the midface located close to the orbits with intensity‐modulated arc therapy: A case report

Gruber

Weidner

Koelbl

2022

Clinical Case Reports

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Noninvasive treatment of two deeply invasive cutaneous squamous cell carcinomas of the midface located close to the orbits with intensity‐modulated arc therapy: A case report

Gruber

Weidner

Koelbl

2022

Clinical Case Reports

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“…The majority of studies on prostate showed superiority of BT over EBRT for rectal and bladder dose. The skin was the only site where the VMAT plans were better for almost all parameters [ 62 , 63 , 65 , 66 , 70 ]. The thin, large-curvature target volume appears to be better irradiated by external beams.…”

Section: Discussionmentioning

confidence: 99%

“…Six studies have been published on the dosimetric comparison of surface mould HDR-BT and VMAT for the treatment of skin lesions on the scalp and the extremities [62][63][64][65][66][67]. Boman et al [63] used four and three plans of patients treated with HDR-BT surface mould on the scalp and lower leg, respectively, and retrospectively created VMAT plans with the PTV created on the CTV of BT plans with an additional 3-mm setup margin.…”

Section: Skinmentioning

confidence: 99%

“…Similar observations were found for the leg cases, except for the D0.1 cm3 of normal tissue, which was lower for BT. In a recent study, Wills et al [66] compared the plan quality of HDR-BT and VMAT for superficial treatment of skin on the scalp and lower limbs with significant curvature. BT plans were retrospectively re-planned for VMAT using identical CT data and CTV/OARs.…”

Section: Skinmentioning

confidence: 99%

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The value of brachytherapy in the age of advanced external beam radiotherapy: a review of the literature in terms of dosimetry

et al. 2021

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Brachytherapy (BT) has long been used for successful treatment of various tumour entities, including prostate, breast and gynaecological cancer. However, particularly due to advances in modern external beam techniques such as intensity-modulated radiotherapy (IMRT), volume modulated arc therapy (VMAT) and stereotactic body radiotherapy (SBRT), there are concerns about its future. Based on a comprehensive literature review, this article aims to summarize the role of BT in cancer treatment and highlight its particular dosimetric advantages. The authors conclude that image-guided BT supported by inverse dose planning will successfully compete with high-tech EBRT in the future and continue to serve as a valuable modality for cancer treatment.

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Efficacy and safety analysis: 24‐month outcomes from a prospective cohort of 106 fields treated with widefield radiation therapy for extensive skin field cancerization, with or without keratinocyte cancers

Spelman,

Potter,

Baker

et al. 2023

JEADV Clinical Practice

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BackgroundWidefield radiation therapy (RT) has emerged as a treatment option for extensive skin field cancerization (ESFC), with or without keratinocyte cancer (KC).ObjectivesTo assess the long‐term efficacy, safety, cosmesis and quality of life outcomes for patients with ESFC ± KC receiving widefield RT.MethodsNDROR (National Dermatology Radiation Oncology Registry) is an open‐label, prospective, nonrandomized, multicentre registry of patients receiving widefield RT at 11 Australian radiation oncology clinics from a single organization. Field/lesion clearance efficacy and cosmesis were assessed in a cohort of patients with at least 24 months follow‐up. Patient‐reported quality of life using EQ‐5D‐5L questionnaires was performed at each visit. Toxicity analysis was performed on data from patients who completed treatment and had at least 3 months follow‐up.ResultsCombined investigator‐assessed field treatment success and lesion clearance at 24 months were ≥96% and 93.5%, respectively. The incidence of new KC within the treated field was 10%. Common Terminology Criteria for Adverse Event grade 1–2 radiation‐induced skin toxicities were reported in >92% of fields at the end of treatment, with 5.8% of fields exhibiting grade 3 toxicities. Toxicity resolved rapidly at the cessation of treatment, with grade 1–2 alopecia and xerosis the most prevalent toxicities after 24 months (51.8% and 43.4%, respectively). Cosmesis in treated fields was assessed as excellent or good in 98% of fields at 24 months. Quality of life significantly improved compared to baseline (baseline: mean visual analogue scale (VAS) 80.65, n = 183) at 24 months follow‐up (mean VAS 84.32, N = 83; improvement of 3.67; p = 0.026).ConclusionsThis analysis indicates that widefield RT is an effective and generally well‐tolerated treatment for ESFC ± KC. Treatment has a favourable safety and cosmesis profile within the period of follow‐up and is associated with significant improvements in quality of life for patients. Widefield RT may be considered for certain patients with extensive disease who have exhausted or are unsuitable for other therapies.

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Dosimetric comparison of volumetric modulated arc therapy (VMAT) and high-dose-rate brachytherapy (HDR-BT) for superficial skin irradiation with significant curvature in one or more planes

Cited by 4 publications

References 26 publications

Noninvasive treatment of two deeply invasive cutaneous squamous cell carcinomas of the midface located close to the orbits with intensity‐modulated arc therapy: A case report

Noninvasive treatment of two deeply invasive cutaneous squamous cell carcinomas of the midface located close to the orbits with intensity‐modulated arc therapy: A case report

The value of brachytherapy in the age of advanced external beam radiotherapy: a review of the literature in terms of dosimetry

Efficacy and safety analysis: 24‐month outcomes from a prospective cohort of 106 fields treated with widefield radiation therapy for extensive skin field cancerization, with or without keratinocyte cancers

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