Dose–volume constraints for head‐and‐neck cancer in carbon ion radiotherapy: A literature review

Varnava, Maria; Saitoh, Jun‐ichi; Tashiro, Mitsuru; Kubo, Nobuteru; Okano, Naoko; Kawamura, Hidemasa; Ohno, Tatsuya

doi:10.1002/cam4.5641

Cited by 2 publications

(1 citation statement)

References 58 publications

(336 reference statements)

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“…In this work, FLASH-RT has been studied using an electron applicator [8] at the beam dose delivery with the FLUKA simulation package [9]. The calculation of the dose-depth percentage in the phantom and the beam characteristics have been obtained for different electron energies of 5, 7, 15, 25, 50, 100 MeV and 1.2 GeV for Poly-methyl-methacrylate (PMMA) and water phantom vs. the penetration depth.…”

Section: Introductionmentioning

confidence: 99%

Simulation Dosimetry Studies for FLASH Radiation Therapy (RT) with Ultra-High Dose Rate (UHDR) Electron Beam

Gazis,

Bignami,

Trachanas

et al. 2024

QuBS

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FLASH-radiotherapy (RT) presents great potential as an alternative to conventional radiotherapy methods in cancer treatment. In this paper, we focus on simulation studies for a linear particle accelerator injector design using the ASTRA code, which permits beam generation and particle tracking through electromagnetic fields. Space charge-dominated beams were selected with the aim of providing an optimized generated beam profile and accelerator lattice with minimized emittance. The main results of the electron beam and ultra-high dose rate (UHDR) simulation dosimetry studies are reported for the FLASH mode radiobiological treatment. Results for the percentage depth dose (PDD) at electron beam energies of 5, 7, 15, 25, 50, 100 MeV and 1.2 GeV for Poly-methyl-methacrylate (PMMA) and water phantom vs. the penetration depth are presented. Additionally, the PDD transverse profile was simulated for the above energies, delivering the beam to the phantom. The simulation dosimetry results provide an UHDR electron beam under the conditions of the FLASH-RT. The performance of the beam inside the phantom and the dose depth depends on the linear accelerator beam’s energy and stability.

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Section: Introductionmentioning

confidence: 99%

Simulation Dosimetry Studies for FLASH Radiation Therapy (RT) with Ultra-High Dose Rate (UHDR) Electron Beam

Gazis,

Bignami,

Trachanas

et al. 2024

QuBS

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Dose–volume constraints for head‐and‐neck cancer in carbon ion radiotherapy: A literature review

et al. 2023

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Head-and-neck (HN) tumors are ranked as the sixth most common malignancy worldwide. Treatment options depend on the stage, anatomical site, and surgical accessibility of the HN tumors. 1 Depending on the stage, squamous cell carcinomas (SCCs) can be treated with surgery, radiotherapy, or a combination of surgery, radiotherapy, and/ or chemotherapy. On the other hand, non-SCCs, being usually resistant to chemotherapy and radiotherapy, have limited treatment options. 2 Carbon ion radiotherapy (CIRT) has various advantages compared with X-ray radiotherapy (XRT). It has higher biological effectiveness than XRT and has already shown promising results for the treatment of resistant tumors like sarcoma, adenocarcinoma, and other non-SCCs. [3][4][5]

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Dose–volume constraints for head‐and‐neck cancer in carbon ion radiotherapy: A literature review

Cited by 2 publications

References 58 publications

Simulation Dosimetry Studies for FLASH Radiation Therapy (RT) with Ultra-High Dose Rate (UHDR) Electron Beam

Simulation Dosimetry Studies for FLASH Radiation Therapy (RT) with Ultra-High Dose Rate (UHDR) Electron Beam

Dose–volume constraints for head‐and‐neck cancer in carbon ion radiotherapy: A literature review

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