Dose-effect of inorganic tin on biochemical indices in rats

Re‐evaluation of stannous chloride (E 512) as food additive

“…The studies of DNA damage induction and inhibition of methyl methane sulfonate (MMS) induced DNA damage repair in Chinese hamster lung cells (V79) using comet assay showed that stannous chloride (anhydrous) induced DNA damage and inhibited MMS-induced DNA repair. The authors suggested that this substance can interfere with DNA repair systems and may thus contribute to increased mutation rate (Viau et al, 2009) Yamaguchi et al (1980) human white blood cells and caused dose-dependent increase of DNA strand breaks, measured by fluorimetric analysis of DNA unwinding (McLean et al, 1983a). In K562 human leukaemia cells, that are resistant to ROS, stannous chloride dihydrate induced significant (p < 0.001) dose-related loss of cell viability and DNA damage.…”

Re‐evaluation of stannous chloride (E 512) as food additive

“…The studies of DNA damage induction and inhibition of methyl methane sulfonate (MMS) induced DNA damage repair in Chinese hamster lung cells (V79) using comet assay showed that stannous chloride (anhydrous) induced DNA damage and inhibited MMS-induced DNA repair. The authors suggested that this substance can interfere with DNA repair systems and may thus contribute to increased mutation rate (Viau et al, 2009) Yamaguchi et al (1980) human white blood cells and caused dose-dependent increase of DNA strand breaks, measured by fluorimetric analysis of DNA unwinding (McLean et al, 1983a). In K562 human leukaemia cells, that are resistant to ROS, stannous chloride dihydrate induced significant (p < 0.001) dose-related loss of cell viability and DNA damage.…”

Re‐evaluation of stannous chloride (E 512) as food additive

“…The studies of DNA damage induction and inhibition of methyl methane sulfonate (MMS) induced DNA damage repair in Chinese hamster lung cells (V79) using comet assay showed that stannous chloride (anhydrous) induced DNA damage and inhibited MMS-induced DNA repair. The authors suggested that this substance can interfere with DNA repair systems and may thus contribute to increased mutation rate (Viau et al, 2009) Yamaguchi et al (1980) human white blood cells and caused dose-dependent increase of DNA strand breaks, measured by fluorimetric analysis of DNA unwinding (McLean et al, 1983a). In K562 human leukaemia cells, that are resistant to ROS, stannous chloride dihydrate induced significant (p < 0.001) dose-related loss of cell viability and DNA damage.…”

Re‐evaluation of stannous chloride (E 512) as food additive

“…The studies of DNA damage induction and inhibition of methyl methane sulfonate (MMS) induced DNA damage repair in Chinese hamster lung cells (V79) using comet assay showed that stannous chloride (anhydrous) induced DNA damage and inhibited MMS-induced DNA repair. The authors suggested that this substance can interfere with DNA repair systems and may thus contribute to increased mutation rate (Viau et al, 2009) Yamaguchi et al (1980) human white blood cells and caused dose-dependent increase of DNA strand breaks, measured by fluorimetric analysis of DNA unwinding (McLean et al, 1983a). In K562 human leukaemia cells, that are resistant to ROS, stannous chloride dihydrate induced significant (p < 0.001) dose-related loss of cell viability and DNA damage.…”