Dorsal raphe and nociceptive stimulations evoke convergent responses on the thalamic centralis lateralis and medial prefrontal cortex neurons

́s-Lara, Miguel Conde; Zapata, Imelda Oman ̃a; ́n-Olea, Martha Leo; ́nchez-Alvarez, Marcela Sa

doi:10.1016/0006-8993(89)91144-x

Cited by 25 publications

(12 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…DLPFC can inhibit medial and dorsal thalami to disrupt functional connection to the midbrain and induce pain relief 17 . This pathway is supported by animal literature 48 , where electrical stimulation of rat prefrontal cortex showed reduced midbrain activation to noxious stimuli on foot 49 . Similar stimulation of cat prefrontal cortex was associated with lower dorsal and medial thalamic activity during pain relief 50 .…”

Section: Discussionsupporting

confidence: 70%

Structural Connectivity Variances Underlie Functional and Behavioral Changes During Pain Relief Induced by Neuromodulation

Lin

Douaud

Filippini

et al. 2017

Sci Rep

View full text Add to dashboard Cite

An increased understanding of the relationship between structural connections and functional and behavioral outcomes is an essential but under-explored topic in neuroscience. During transcranial direct current stimulation (tDCS)–induced analgesia, neuromodulation occurs through a top-down process that depends on inter-regional connections. To investigate whether variation in anatomical connectivity explains functional and behavorial outcomes during neuromodulation, we first combined tDCS and a tonic pain model with concurrent arterial spin labelling that measures cerebral perfusion related to ongoing neural activity. Left dorsolateral prefrontal cortex (L-DLPFC) tDCS induced an analgesic effect, which was explained by reduced perfusion to posterior insula and thalamus. Second, we used diffusion imaging to assess white matter structural integrity between L-DLPFC and thalamus, two key components of the neuromodulatory network. Fractional anisotropy of this tract correlated positively with functional and behavioral modulations. This suggests structural dependence by the neuromodulatory process to induce analgesia with potential relevance for patient stratification.

show abstract

Section: Discussionsupporting

confidence: 70%

Structural Connectivity Variances Underlie Functional and Behavioral Changes During Pain Relief Induced by Neuromodulation

Lin

Douaud

Filippini

et al. 2017

Sci Rep

View full text Add to dashboard Cite

show abstract

“…37, 38 DLPFC transcranial magnetic stimulation increases thermal pain thresholds and pain tolerance and reduces postoperative pain, neuropathic pain, fibromyalgia symptoms, and may reduce migraine symptoms. 39–44 Enhanced pain-induced activation of DLPFC in migraineurs and the correlation between DLPFC activation and headache frequency found in our study might indicate that greater pain-induced DLPFC activation is a pain-inhibiting and compensatory response.…”

Section: Discussionmentioning

confidence: 99%

Enhanced pain-induced activity of pain-processing regions in a case-control study of episodic migraine

et al. 2014

View full text Add to dashboard Cite

Objective To identify brain regions having aberrant pain-induced activation in migraineurs, thereby gaining insight into particular aspects of pain processing that are atypical in migraineurs. Methods Functional magnetic resonance imaging assessed whole brain responses to painful heat in 24 adult episodic migraineurs who were at least 48 hours pain free and 27 healthy controls. Regions differentially activated in migraineurs compared to controls were identified. Activation intensities in these regions were correlated with headache frequency, number of migraine years, and time to next migraine attack. Results Migraineurs had greater pain-induced activation of lentiform nucleus, fusiform gyrus, subthalamic nucleus, hippocampus, middle cingulate cortex, premotor cortex, somatosensory cortex and dorsolateral prefrontal cortex, and less activation in precentral gyrus and superior temporal gyrus. There were significant correlations between activation strength and headache frequency for middle cingulate (r=0.627, p=.001), right dorsolateral prefrontal cortex (r=.568, p=.004), left fusiform gyrus (r=0.487, p=.016), left precentral gyrus (r=.415, p=.044), and left hippocampus (r=0.404, p=.050) and with number of migraine years for left fusiform gyrus (r=0.425, p=.038). There were no significant correlations between activation strength and time to next migraine attack. Conclusions The majority of regions with enhanced pain-induced activation in headache-free migraineurs participate in cognitive aspects of pain perception such as attending to pain and pain memory. Enhanced cognitive pain processing by migraineurs might reflect cerebral hypersensitivity related to high expectations and hypervigilance for pain.

show abstract

“…Reciprocal anatomical connections between PFC, PAG, and rostroventromedial medulla have been documented using retrograde tracing (An et al, 1998;Bragin et al, 1984) and c-fos immmunoreactivity (Lim et al, 2009). These projections have been shown to have physiological relevance for nociception and pain (Condes-Lara et al, 1989). In rats and cats alike, electrical stimulation of various cingulofrontal regions produces behaviorally relevant analgesia that is correlated with reduced thalamic and midbrain spiking activity in response to noxious stimuli (Andersen, 1986;Hardy and Haigler, 1985;Hutchison et al, 1996).…”

Section: Evidence For a Top-down Analgesic Circuitmentioning

confidence: 99%

Naloxone-Reversible Modulation of Pain Circuitry by Left Prefrontal rTMS

Taylor

Borckardt

Canterberry

et al. 2013

Neuropsychopharmacol

View full text Add to dashboard Cite

A 20-minute session of 10 Hz repetitive transcranial magnetic stimulation (rTMS) of Brodmann Area (BA) nine of the left dorsolateral prefrontal cortex (DLPFC) can produce analgesic effects on postoperative and laboratory-induced pain. This analgesia is blocked by pretreatment with naloxone, a μ-opioid antagonist. The purpose of this sham-controlled, double-blind, crossover study was to identify the neural circuitry that underlies the analgesic effects of left DLPFC rTMS, and to examine how the function of this circuit, including midbrain and medulla, changes during opioid blockade. Fourteen healthy volunteers were randomized to receive intravenous saline or naloxone immediately before sham and real left DLPFC rTMS on the same experimental visit. One week later, each participant received the novel pretreatment but the same stimulation paradigm. Using short sessions of heat on capsaicin-sensitized skin, hot allodynia was assessed during 3 Tesla functional magnetic resonance imaging (fMRI) scanning at baseline, post-sham rTMS, and post-real rTMS. Data were analyzed using whole-brain voxel-based analysis, as well as time series extractions from anatomically-defined regions of interest representing midbrain and medulla. Consistent with previous findings, real rTMS significantly reduced hot allodynia pain ratings. This analgesia was associated with elevated blood oxygenation-level dependent (BOLD) signal in BAs 9 and 10, and diminished BOLD signal in the anterior cingulate, thalamus, midbrain, and medulla during pain. Naloxone pretreatment largely abolished rTMS-induced analgesia, as well as rTMS-induced attenuation of BOLD signal response to painful stimuli throughout pain processing regions, including midbrain and medulla. These preliminary results suggest that left DLPFC rTMS drives top-down opioidergic analgesia.

show abstract

Dorsal raphe and nociceptive stimulations evoke convergent responses on the thalamic centralis lateralis and medial prefrontal cortex neurons

Cited by 25 publications

References 28 publications

Structural Connectivity Variances Underlie Functional and Behavioral Changes During Pain Relief Induced by Neuromodulation

Structural Connectivity Variances Underlie Functional and Behavioral Changes During Pain Relief Induced by Neuromodulation

Enhanced pain-induced activity of pain-processing regions in a case-control study of episodic migraine

Naloxone-Reversible Modulation of Pain Circuitry by Left Prefrontal rTMS

Contact Info

Product

Resources

About