Dopaminergic D₁and D₂Receptors Are Essential for the Arousal Effect of Modafinil

Abstract

Modafinil is a wake-promoting compound with low abuse potential used in the treatment of narcolepsy. Although the compound is reported to affect multiple neurotransmitter systems such as catecholamines, serotonin, glutamate, GABA, orexin, and histamine, however, the molecular mechanism by which modafinil increases wakefulness is debated. Herein we used dopamine (

Medication Development for the Treatment of Cocaine Addiction – Progress at Preclinical and Clinical Levels

“…Recent studies suggest that modafinil is a DAT inhibitor in humans and primates (Madras et al, 2006;Volkow et al, 2009). This is further supported by the findings that mice lacking DAT or DA (D1 and D2) receptors do not respond to the wake-promoting effects of modafinil (Qu et al, 2008;Wisor et al, 2001). In vivo microdialysis studies demonstrated that modafinil increases extracellular DA (Wisor et al, 2001;Ferraro et al, 1997;Murillo-Rodríguez et al, 2007).…”

Entire Frequency Domain Analysis of Rodent EEG and EMG Recordings Using Relative Thresholds

“…EEG and EMG recording were made using SLEEPSIGN (Kissei Comtec, Nagano, Japan) [8]. Following data collection, polygraphic recordings were automatically scored offline using SLEEPSIGN (4-s epochs) to determine periods of wakefulness, rapid eye movement (REM) sleep, and non-REM (NREM) sleep, according to standard criteria [8][9][10]. Finally, the defined sleep/wake stages were visually examined and corrected when necessary.…”

GP guide to drugs used in palliative care: psychostimulants

“…However, evidence in both animals and humans supports a predominantly dopamine-mediated action. [3][4][5] Further, it shares many of the psychiatric complications and abuse potential of other psychostimulants. 1 • psychostimulants are only initiated by palliative-care specialists and for short-term use; the GP would only take over prescribing where longerterm use is envisaged or where it is in the patient's best interest…”