Dopamine-somatostatin interactions in the rat striatum: An in vivo microdialysis study

Somatostatin Potently Stimulates In Vivo Striatal Dopamine and γ‐Aminobutyric Acid Release by a Glutamate‐Dependent Action

“…Our findings for the effects of SRIF on DA release contrast markedly with those reported in a previous microdialysis study (Thermos et al, 1996), where relatively modest increases were seen (around twofold) and only at a very high dose (l0~M), which is unlikely to be of physiological significance. It is interesting that Thermos et al (1996) did not find any effects of SRIF at 10_6 M, whereas we did observe significant increases in DA concentrations at this dose, although they were significantly less than those observed at I 0M…”

Activation of somatostatin receptors in the globus pallidus increases rat locomotor activity and dopamine release in the striatum

“…In vivo microdialysis studies have shown SRIF to increase dopamine release when infused bilaterally in the rat striatum (Thermos et al 1996), while the unilateral striatal infusion in the mouse led to the increase of dopamine release and subsequent locomotor activity . SRIF's effect on dopamine release was shown to be glutamate-dependent and mediated by the activation of the sst 2 subtype (Hathway et al 1999).…”

Mapping of tyrosine hydroxylase in the diencephalon of alpaca (Lama pacos) and co-distribution with somatostatin-28 (1-12)

“…It is possible that interactions at intra-cellular level could include molecules of somatostatin of different lengths from the (1-12) fragment, since we did not find double-labelled neurons. A good candidate could be somatostatin-14, first isolated from the hypothalamus (Bouras et al, 1987), and already described as a modulator of dopamine release in rat striatum (Thermos et al, 1996).…”