Dopamine receptors in the striatum of rats exposed to repeated restraint stress and alprazolam treatment

Giardino, Luciana; Zanni, Massimo; Pozza, Monica; Bettelli, Carla; Covelli, Venusia

doi:10.1016/s0014-2999(97)01608-7

Cited by 20 publications

(10 citation statements)

References 19 publications

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“…A study showed that there were no alterations in D 2 receptor density during chronic restraint stress in striatum [43]. There is also a report in which D 2 receptor density were not altered after status epilepticus in frontal cortex in spite of decreased DA levels [44].…”

Section: Discussionmentioning

confidence: 97%

Differential Response of Central Dopaminergic System in Acute and Chronic Unpredictable Stress Models in Rats

et al. 2009

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We aimed to evaluate the response of dopaminergic system in acute stress (AS) and chronic unpredictable stress (CUS) by measuring dopamine (DA) levels, its receptor densities in the frontal cortex, striatum, hippocampus, amygdala and orbito-frontal cortex regions of rat brain, and investigated the corresponding behavioral locomotor changes. Involvement of D(1) receptor was also examined during AS and CUS using A 68930, a D(1) selective agonist. Rats were exposed to AS (single immobilization for 150 min) and CUS (two different stressors for 7 days). AS significantly decreased the DA levels in the striatum and hippocampus, and A 68930 pretreatment significantly reverted these changes. However, in the frontal cortex significantly increased DA levels were remain unchanged following A 68930. CUS led to a decrease of DA levels in the frontal cortex, striatum and hippocampus, which were normalized by A 68930. Saturation radioligand binding assays revealed a significant decrease in the number of D(1)-like receptors in the frontal cortex during CUS, which were further decreased by A 68930 pretreatment. However, in the striatum and hippocampus, A 68930 pretreatment reduced the CUS induced increase in the number of D(1)-like receptors. No significant changes were observed in the amygdala and orbito-frontal cortex during AS and CUS, while D(2)-like receptors were unchanged in all the brain regions studied. Locomotor activity was significantly decreased in both the stress models, A 68930 pretreatment significantly increased stereotypic counts and horizontal activity. Thus, present investigation provide insights into the differential regional response of dopaminergic system during AS and CUS. Further, neurochemical and behavioral effects of D(1) agonist pretreatment suggest specific modulatory role of D(1) receptor under such stressful episodes.

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Section: Discussionmentioning

confidence: 97%

Differential Response of Central Dopaminergic System in Acute and Chronic Unpredictable Stress Models in Rats

et al. 2009

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“…Moreover, acupuncture attenuates stress-induced physiological responses via a central GABA pathway (Iwa et al 2006). Neuronal suppression in the NAc and other stress-related areas is also produced by anxiolytic agents that potentiate inhibitory GABA transmission (Finlay et al 1995; Giardino et al 1998). Accordingly, it seems reasonable to propose that acupuncture inhibits stress-induced expression of c-Fos and CREB in the NAc, presumably via activation of inhibitory GABA transmission.…”

Section: Discussionmentioning

confidence: 99%

Effects of acupuncture on stress-induced relapse to cocaine-seeking in rats

et al. 2012

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Rationale Cocaine addiction is associated with high rates of relapse, and stress has been identified as a major risk factor. We have previously demonstrated that acupuncture reduces drug self-administration and dopamine release in the nucleus accumbens (NAc), a brain structure implicated in stress-induced reinstatement of drug-seeking behavior. Objective This study was conducted to investigate the effects of acupuncture on footshock-induced reinstatement of cocaine-seeking and the expression of c-Fos and the transcription factor cAMP response element-binding protein (CREB) in the NAc, used as markers of neuronal activation in conditions of stress-induced reinstatement to cocaine. Methods Male Sprague–Dawley rats were trained to self-administer cocaine (1.0 mg/kg) for 14 days, followed by extinction and then footshock stress. Acupuncture was applied at bilateral Shenmen (HT7) points for 1 min after footshock stress. Results and conclusions Acute footshock stress reinstated cocaine-seeking behavior and enhanced c-Fos expression and phosphorylated CREB (pCREB) activation in the NAc shell in cocaine pre-exposed rats. On the other hand, acupuncture at HT7, but not at control point (LI5), markedly reduced reinstatement of cocaine-seeking (86.5 % inhibition vs. control value), c-Fos expression (81.7% inhibition), and pCREB activation (79.3% inhibition) in the NAc shell. These results suggest that acupuncture attenuates stress-induced relapse by regulating neuronal activation in the NAc shell.

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“…D 1 mRNA expression in the NAcc was unaffected by the 8-week CVS, whilst D 2 mRNA levels were reduced [62] . However, a decrease in NAcc D 1 receptor binding, but not in affinity, has been found after chronic restraint stress, whereas no stress-dependent effect on the functional state of D 2 receptors was observed in the NAcc and dorsal striatum, as well as D 1 receptors in the dorsal striatum [63] . In single-housed male Wistar rats, neither a weeklong restraint stress nor a 2-week CVS produced differences in dopamine D 1 and D 2 receptor mRNA expression in the NAcc.…”

Section: Discussionmentioning

confidence: 86%

“…Similarly, repeated immobilisation stress increases D 2 receptor binding in the NAcc when animals are single housed after stress, whereas pair-housing after stress is associated with increased D 2 binding in the dorsal striatum [71] . On the other hand, in several studies no chronic stress-associated change in the functional state of D 2 has been observed, either in the NAcc or in the dorsal striatum [55,56,63,64] . Considering the stress !…”

Section: Discussionmentioning

confidence: 88%

Activating Effects of Chronic Variable Stress in Rats with Different Exploratory Activity: Association with Dopamine D1 Receptor Function in Nucleus Accumbens

Matrov¹,

Vonk

Herm

et al. 2011

Neuropsychobiology

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Background/Aims: Rats display persistent behavioural phenotypes of low (LE) versus high (HE) exploratory activity in the exploration box paradigm. LE rats that prefer passive coping strategies show differential dopaminergic activity in the striatum. The main hypothesis of this study was that chronic variable stress (CVS) would have a higher impact on LE rats. Methods: Animals were submitted to a CVS regimen lasting 32 days that was followed by a behavioural test battery. The functional states of their dopamine D₁ and D₂ receptors were measured in the striatum and nucleus accumbens (NAcc). Cerebral oxidative metabolism was assessed via cytochrome c oxidase histochemistry in 65 brain regions. Results: CVS decreased weight gain, to a higher extent in LE rats, and lowered the sucrose preference after the first week, but habituation to the anhedonic effect had developed by the end of the experiment. CVS did not change the behavioural phenotypes initially assigned. No effect of stress on D₂ receptor function was found. Chronically stressed animals exhibited higher levels of social interaction and D₁ receptor-mediated cAMP accumulation in the NAcc, but not in the striatum. CVS was associated with higher oxidative metabolism levels in the anteroventral thalamus, median raphe nuclei and central periaqueductal grey matter. These changes after stress did not depend upon the exploratory phenotype. Conclusion: This study revealed changes in brain biochemistry after habituation to CVS that might be implicated in successful adaptation to chronic stress.

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Dopamine receptors in the striatum of rats exposed to repeated restraint stress and alprazolam treatment

Cited by 20 publications

References 19 publications

Differential Response of Central Dopaminergic System in Acute and Chronic Unpredictable Stress Models in Rats

Differential Response of Central Dopaminergic System in Acute and Chronic Unpredictable Stress Models in Rats

Effects of acupuncture on stress-induced relapse to cocaine-seeking in rats

Activating Effects of Chronic Variable Stress in Rats with Different Exploratory Activity: Association with Dopamine D1 Receptor Function in Nucleus Accumbens

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