Dopamine for prevention of morbidity and mortality in term newborn infants with suspected perinatal asphyxia

Predictors of neurological outcome in cooled neonates

“…Our data revealed that patients with poor outcomes required higher doses of dobutamine than those with normal outcome. Inotrope dosage can highly vary according to the strategy of each institute and clinician, and no sufficient evidences currently exist about efficacy of inotrope to improve their mortality or long‐term neurodevelopmental outcome . Our results, at least, suggested that worse cardiac function can be an indicator of poor prognosis of cooled infants.…”

Predictors of neurological outcome in cooled neonates

“…Our data revealed that patients with poor outcomes required higher doses of dobutamine than those with normal outcome. Inotrope dosage can highly vary according to the strategy of each institute and clinician, and no sufficient evidences currently exist about efficacy of inotrope to improve their mortality or long‐term neurodevelopmental outcome . Our results, at least, suggested that worse cardiac function can be an indicator of poor prognosis of cooled infants.…”

Transient NMDA receptor‐mediated hypoperfusion following umbilical cord occlusion in preterm fetal sheep

“…Further, we have previously presented evidence that peripheral vasoconstriction, particularly in the gut, is important in maintaining blood pressure at a time of transiently impaired myocardial function (Quaedackers et al 2004a). A similar phenomenon is seen in the adult during shock (Reilly et al 2001;Ceppa et al 2003), and both clinical and experimental data show that reversible myocardial injury and associated cardiac dysfunction are common during recovery from exposure to perinatal asphyxia (Gunn et al 2000;Lumbers et al 2001;Hunt & Osborn, 2002).…”

Acute Systemic Complications in the Preterm Fetus After Asphyxia: Role of Cardiovascular and Blood Flow Responses

“…There is considerable clinical and experimental evidence to show that reversible myocardial injury and associated cardiac dysfunction are common during recovery from exposure to perinatal asphyxia 114–116 . Consistent with the hypothesis of early myocardial dysfunction, an infusion of the α‐adrenoceptor antagonist phentolamine led to a reduction in blood pressure for 3–4 hours despite normalization of SMA blood flow for most of this period (Fig.…”

Predictors of neurological outcome in cooled neonates

“…Our data revealed that patients with poor outcomes required higher doses of dobutamine than those with normal outcome. Inotrope dosage can highly vary according to the strategy of each institute and clinician, and no sufficient evidences currently exist about efficacy of inotrope to improve their mortality or long‐term neurodevelopmental outcome . Our results, at least, suggested that worse cardiac function can be an indicator of poor prognosis of cooled infants.…”

Transient NMDA receptor‐mediated hypoperfusion following umbilical cord occlusion in preterm fetal sheep

“…Further, we have previously presented evidence that peripheral vasoconstriction, particularly in the gut, is important in maintaining blood pressure at a time of transiently impaired myocardial function (Quaedackers et al 2004a). A similar phenomenon is seen in the adult during shock (Reilly et al 2001;Ceppa et al 2003), and both clinical and experimental data show that reversible myocardial injury and associated cardiac dysfunction are common during recovery from exposure to perinatal asphyxia (Gunn et al 2000;Lumbers et al 2001;Hunt & Osborn, 2002).…”

Acute Systemic Complications in the Preterm Fetus After Asphyxia: Role of Cardiovascular and Blood Flow Responses

“…There is considerable clinical and experimental evidence to show that reversible myocardial injury and associated cardiac dysfunction are common during recovery from exposure to perinatal asphyxia 114–116 . Consistent with the hypothesis of early myocardial dysfunction, an infusion of the α‐adrenoceptor antagonist phentolamine led to a reduction in blood pressure for 3–4 hours despite normalization of SMA blood flow for most of this period (Fig.…”

Predictors of neurological outcome in cooled neonates

“…Our data revealed that patients with poor outcomes required higher doses of dobutamine than those with normal outcome. Inotrope dosage can highly vary according to the strategy of each institute and clinician, and no sufficient evidences currently exist about efficacy of inotrope to improve their mortality or long‐term neurodevelopmental outcome . Our results, at least, suggested that worse cardiac function can be an indicator of poor prognosis of cooled infants.…”

Transient NMDA receptor‐mediated hypoperfusion following umbilical cord occlusion in preterm fetal sheep

“…Further, we have previously presented evidence that peripheral vasoconstriction, particularly in the gut, is important in maintaining blood pressure at a time of transiently impaired myocardial function (Quaedackers et al 2004a). A similar phenomenon is seen in the adult during shock (Reilly et al 2001;Ceppa et al 2003), and both clinical and experimental data show that reversible myocardial injury and associated cardiac dysfunction are common during recovery from exposure to perinatal asphyxia (Gunn et al 2000;Lumbers et al 2001;Hunt & Osborn, 2002).…”

Acute Systemic Complications in the Preterm Fetus After Asphyxia: Role of Cardiovascular and Blood Flow Responses

“…There is considerable clinical and experimental evidence to show that reversible myocardial injury and associated cardiac dysfunction are common during recovery from exposure to perinatal asphyxia 114–116 . Consistent with the hypothesis of early myocardial dysfunction, an infusion of the α‐adrenoceptor antagonist phentolamine led to a reduction in blood pressure for 3–4 hours despite normalization of SMA blood flow for most of this period (Fig.…”