Dopamine fiber detection by [11C]-CFT and PET in a primate model of parkinsonism

Hantraye, Philippe; Brownell, Anna Liisa; Elmaleh, David R.; Spealman, Roger D.; Wüllner, U.; Brownell, G.L.; Madras, Bertha K.; Isacson, O

doi:10.1097/00001756-199203000-00013

Cited by 88 publications

(57 citation statements)

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“…These reports indicate the difficulty of making a precise evaluation of possible PD cases based solely on clinical data. In contrast, depicting abnormalities of the dopamine system on a molecular basis has a greater advantage (6,(20)(21)(22)(23)(24)(25). Previous studies showed that the progression of PD was associated with a similar rate of dopaminergic losses in all striatal subregions (26).…”

Section: Discussionmentioning

confidence: 99%

Progression from Unilateral to Bilateral Parkinsonism in Early Parkinson Disease: Implication of Mesocortical Dopamine Dysfunction by PET

Yagi

Yoshikawa²,

Futatsubashi³

et al. 2010

J Nucl Med

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Section: Discussionmentioning

confidence: 99%

Progression from Unilateral to Bilateral Parkinsonism in Early Parkinson Disease: Implication of Mesocortical Dopamine Dysfunction by PET

Yagi

Yoshikawa²,

Futatsubashi³

et al. 2010

J Nucl Med

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“…We found a noisy, but significant, correlation between 11 C-CFT binding potential in the putamen and rCBV changes in both midbrain and striatum. CFT, a selective ligand for DAT, provides a validated measure of DA presynaptic terminals in monkeys (Hantraye et al, 1992). In MPTP-treated primates, severe reduction in 11 C-CFT binding is correlated with development of motor symptoms (Brownell et al, 1998b).…”

Section: Discussionmentioning

confidence: 99%

Mapping Dopamine Function in Primates Using Pharmacologic Magnetic Resonance Imaging

Jenkins¹,

Sánchez‐Pernaute²,

Brownell³

et al. 2004

J. Neurosci.

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Dopamine (DA) receptors play a central role in such diverse pathologies as Parkinson's disease, schizophrenia, and drug abuse. We used an amphetamine challenge combined with pharmacologic magnetic resonance imaging (phMRI) to map DA-associated circuitry in nonhuman primates with high sensitivity and spatial resolution. Seven control cynomolgous monkeys and 10 MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)-treated parkinsonian primates were studied longitudinally using both positron emission tomography (PET) and phMRI. Amphetamine challenge (2.5 mg/kg, i.v.) in control monkeys increased relative cerebral blood volume (rCBV) in a number of brain regions not described previously, such as parafascicular thalamus, precentral gyrus, and dentate nucleus of the cerebellum. With the high spatial resolution, we were also able to readily identify changes in rCBV in the anterior cingulate, substantia nigra, ventral tegmental area, caudate (tail and head), putamen, and nucleus accumbens. Amphetamine induced decreases in rCBV in occipital and posterior parietal cortices. Parkinsonian primates had a prominent loss of response to amphetamine, with relative sparing of the nucleus accumbens and parafascicular thalamus. There was a significant correlation between rCBV loss in the substantia nigra and both PET imaging of dopamine transporters and behavioral measures. Monkeys with partial lesions as defined by 2␤-carbomethoxy-3␤-(4-fluorophenyl) tropane binding to dopamine transporters showed recruitment of premotor and motor cortex after amphetamine stimulus similar to what has been noted in Parkinson's patients during motor tasks. These data indicate that phMRI is a powerful tool for assessment of dynamic changes associated with normal and dysfunctional DA brain circuitry in primates.

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“…11 C]CFT (Kaufman and Madras, 1991;Hantraye et al, 1992;Morris et al, 1996;Madras et al, 1998;Saka et al, 2004). PET imaging was conducted with monkeys initially anesthetized with ketamine/xylazine (15.0/1.5 mg/kg) and then maintained under general anesthesia with halothane.…”

Section: Methodsmentioning

confidence: 99%

Modafinil Occupies Dopamine and Norepinephrine Transporters in Vivo and Modulates the Transporters and Trace Amine Activity in Vitro

Madras¹,

Xie²,

Lin³

et al. 2006

J Pharmacol Exp Ther

303

254

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Dopamine fiber detection by [11C]-CFT and PET in a primate model of parkinsonism

Cited by 88 publications

References 0 publications

Progression from Unilateral to Bilateral Parkinsonism in Early Parkinson Disease: Implication of Mesocortical Dopamine Dysfunction by PET

Progression from Unilateral to Bilateral Parkinsonism in Early Parkinson Disease: Implication of Mesocortical Dopamine Dysfunction by PET

Mapping Dopamine Function in Primates Using Pharmacologic Magnetic Resonance Imaging

Modafinil Occupies Dopamine and Norepinephrine Transporters in Vivo and Modulates the Transporters and Trace Amine Activity in Vitro

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