Dopamine D1 receptor expression is bipolar cell type‐specific in the mouse retina

Farshi, Pershang; Fyk‐Kolodziej, Bozena; Krolewski, David M.; Walker, Paul D.; Ichinose, Tomomi

doi:10.1002/cne.23932

Cited by 46 publications

(45 citation statements)

References 82 publications

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“…8 Lavoie and colleagues 8 observed a reduction in the b-wave amplitude at all light intensities in both photopic and scotopic conditions in dopamine D1 receptor knockout (D1R-KO) mice and commented on the similarity between D1R-KO results and high-risk schizophrenic offsprings. However, this reduction in b-wave was expected from knockingout the D1 receptor, a dopamine receptor type known to be expressed in bipolar cells 72 and essential for normal response to light adaptation from bipolar cells. 73,74 Although other monoamine-deficient mice were examined and no significant differences were observed, the question now is whether there are any deficiencies in the fERGs of the mice tested by Lavoie et al 8 during mesopic adaptation, specifically on the three dopamine transgenic mice tested, as dopamine is known to modulate the electrical coupling of the gap junction between rods and cones in the switch between photopic and mesopic lighting.…”

Section: Discussionmentioning

confidence: 99%

Electroretinographic Abnormalities and Sex Differences Detected with Mesopic Adaptation in a Mouse Model of Schizophrenia: A and B Wave Analysis

Jimenez

Lines

Kueppers

et al. 2020

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. Mesopic flash electroretinography (fERG) as a tool to identify N-methyl-Daspartate receptor (NMDAR) hypofunction in subjects with schizophrenia shows great potential. We report the first fERG study in a genetic mouse model of schizophrenia characterized by NMDAR hypofunction from gene silencing of serine racemase (SR) expression (SR-/-), an established risk gene for schizophrenia. We analyzed fERG parameters under various background light adaptations to determine the most significant variables to allow for early identification of people at risk for schizophrenia, prior to onset of psychosis. SR is a risk gene for schizophrenia, and negative and cognitive symptoms antedate the onset of psychosis that is required for diagnosis. METHODS. The scotopic, photopic, and mesopic fERGs were analyzed in male and female mice in both SR-/and wild-type (WT) mice and also analyzed for sex differences. Amplitude and implicit time of the a-and b-wave components, b-/a-wave ratio, and Fourier transform analysis were analyzed. RESULTS. Mesopic a-and b-wave implicit times were significantly delayed, and b-wave amplitudes, b/a ratios, and Fourier transform were significantly decreased in the male SR-/mice compared to WT, but not in female SR-/mice. No significant differences were observed in photopic or scotopic fERGs between genotype. CONCLUSIONS. The fERG prognostic capability may be improved by examination of background light adaptation, a larger array of light intensities, considering sex as a variable, and performing Fourier transform analyses of all waveforms. This should improve the ability to differentiate between controls and subjects with schizophrenia characterized by NMDAR hypofunction.

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Section: Discussionmentioning

confidence: 99%

Electroretinographic Abnormalities and Sex Differences Detected with Mesopic Adaptation in a Mouse Model of Schizophrenia: A and B Wave Analysis

Jimenez

Lines

Kueppers

et al. 2020

Invest. Ophthalmol. Vis. Sci.

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“…Dopamine signaling may interact with the visual pathways by two possible mechanisms to modulate visually-driven eye growth: a) dopamine may act on the DA receptors in specific visual pathways and influence the pathways’ functions or b) visual pathway activity may influence myopia development by altering DA release and signaling. By acting on DA receptors expressed in different visual pathways, dopamine may modulate ON pathways (Farshi et al, 2016; Smith et al, 2015), OFF pathways (Maguire and Werblin, 1994; Yang et al, 2013), rod pathways (Herrmann et al, 2011) and retinal gap junctions (Bu et al, 2014; Kothmann et al, 2009; Zhang et al, 2011a), contributing to control of myopia development (Chakraborty et al, 2014; Chakraborty et al, 2015c; Park et al, 2014). Alternatively, visual inputs such as bright light and flickering light, stimulate ON pathway and ipRGC and alter dopamine synthesis and release (Contini et al, 2010; Dumitrescu et al, 2009b; Prigge et al, 2016a).…”

Section: Da Signaling and Visual Pathway Interactions In Myopiamentioning

confidence: 99%

Dopamine signaling and myopia development: What are the key challenges

Zhou

Pardue

Iuvone

et al. 2017

Progress in Retinal and Eye Research

230

203

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In the face of an “epidemic” increase in myopia over the last decades and myopia prevalence predicted to reach 2.5 billion people by the end of this decade, there is an urgent need to develop effective and safe therapeutic interventions to slow down this “myopia booming” and prevent myopia-related complications and vision loss. Dopamine (DA) is an important neurotransmitter in the retina and mediates diverse functions including development, visual signaling, and refractive development. Inspired by the convergence of epidemiological and animal studies in support of the inverse relationship between outdoor activity and risk of developing myopia and by the close biological relationship between light exposure and dopamine release/signaling, we felt it is timely and important to critically review the role of DA in myopia development. This review will revisit several key points of evidence for and against DA mediating light control of myopia: 1) the causal role of extracellular retinal DA levels, 2) the mechanism and action of dopamine D1 and D2 receptors and 3) the roles of cellular/circuit retinal pathways. We examine the experiments that show causation by altering DA, DA receptors and visual pathways using pharmacological, transgenic, or visual environment approaches. Furthermore, we critically evaluate the safety issues of a DA-based treatment strategy and some approaches to address these issues. The review identifies the key questions and challenges in translating basic knowledge on DA signaling and myopia from animal studies into effective pharmacological treatments for myopia in children.

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“…Dopamine released in the retina solely by dopaminergic amacrine cells in the light [23][24][25] plays a key role in visual processing, synaptic formation, synaptic transmission, and light adaptation [26,27]. Dopamine D1 receptors are located on horizontal cells, bipolar cells, amacrine cells (ACs) and RGCs [28,29]; dopamine D2 receptors are expressed by photoreceptors, ACs and RGCs [27,[30][31][32]. Dopamine is arguably involved in visual experience-modulated eye growth [33,34].…”

Section: Introductionmentioning

confidence: 99%

Defocused Images Change Multineuronal Firing Patterns in the Mouse Retina

Banerjee

Wang

et al. 2020

Cells

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Myopia is a major public health problem, affecting one third of the population over 12 years old in the United States and more than 80% of people in Hong Kong. Myopia is attributable to elongation of the eyeball in response to defocused images that alter eye growth and refraction. It is known that the retina can sense the focus of an image, but the effects of defocused images on signaling of population of retinal ganglion cells (RGCs) that account either for emmetropization or refractive errors has still to be elucidated. Thorough knowledge of the underlying mechanisms could provide insight to understanding myopia. In this study, we found that focused and defocused images can change both excitatory and inhibitory conductance of ON alpha, OFF alpha and ON-OFF retinal ganglion cells in the mouse retina. The firing patterns of population of RGCs vary under the different powers of defocused images and can be affected by dopamine receptor agonists/antagonists' application. OFF-delayed RGCs or displaced amacrine cells (dACs) with time latency of more than 0.3 s had synchrony firing with other RGCs and/or dACs. These spatial synchrony firing patterns between OFF-delayed cell and other RGCs/dACs were significantly changed by defocused image, which may relate to edge detection. The results suggested that defocused images induced changes in the multineuronal firing patterns and whole cell conductance in the mouse retina. The multineuronal firing patterns can be affected by dopamine receptors' agonists and antagonists. Synchronous firing of OFF-delayed cells is possibly related to edge detection, and understanding of this process may reveal a potential therapeutic target for myopia patients.

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Dopamine D1 receptor expression is bipolar cell type‐specific in the mouse retina

Cited by 46 publications

References 82 publications

Electroretinographic Abnormalities and Sex Differences Detected with Mesopic Adaptation in a Mouse Model of Schizophrenia: A and B Wave Analysis

Electroretinographic Abnormalities and Sex Differences Detected with Mesopic Adaptation in a Mouse Model of Schizophrenia: A and B Wave Analysis

Dopamine signaling and myopia development: What are the key challenges

Defocused Images Change Multineuronal Firing Patterns in the Mouse Retina

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