Dopamine D ₁ signaling organizes network dynamics underlying working memory

Abstract

Dopamine orchestrates changes in cortical network synchrony that underlie working memory, as revealed with simultaneous PET-MRI.

Dopamine D2/3Binding Potential Modulates Neural Signatures of Working Memory in a Load-Dependent Fashion

“…This finding is in contrast to a recent study by Roffman et al (2016), showing that striatal and extrastriatal DA D 1 selectively influence functional integrity of different large-scale systems during a WM task. Reasons for this discrepancy may stem from age differences across samples, differences in the kind of BOLD measures [BOLD amplitude in the current vs connectivity in the study by Roffman et al (2016)], or differences in the type of receptor binding examined and the ligands that are used (DA D 2/3 -sensitive raclopride in the current sample), which play different roles in facilitating WM performance. Although BOLD–DA associations were stronger in extrastriatal than striatal regions, these associations were similarly expressed for both striatal and extrastriatal regions within each group.…”

Dopamine D2/3Binding Potential Modulates Neural Signatures of Working Memory in a Load-Dependent Fashion

“…This finding is in contrast to a recent study by Roffman et al (2016), showing that striatal and extrastriatal DA D 1 selectively influence functional integrity of different large-scale systems during a WM task. Reasons for this discrepancy may stem from age differences across samples, differences in the kind of BOLD measures [BOLD amplitude in the current vs connectivity in the study by Roffman et al (2016)], or differences in the type of receptor binding examined and the ligands that are used (DA D 2/3 -sensitive raclopride in the current sample), which play different roles in facilitating WM performance. Although BOLD–DA associations were stronger in extrastriatal than striatal regions, these associations were similarly expressed for both striatal and extrastriatal regions within each group.…”

Reversible Photocontrol of Dopaminergic Transmission in Wild-Type Animals

“…This could be due to the diffusion (and therefore dilution) of azodopa within cortical tissue over time, and possibly to its metabolic washout and reuptake by synaptic terminals [ 58 ]. The increase of cortical activity by trans -azodopa is consistent with our results from functional studies in cell cultures and suggests that trans -azodopa may also act as a dopamine agonist in the mouse brain [ 59 ]. The general excitatory action of azodopa was modulated by UV light in individual neurons, some of which revealed a decrease in spiking activity while others increased it.…”

Dedifferentiation of caudate functional organization is linked to reduced D1 dopamine receptor availability and poorer memory function in aging

“…We further provide novel evidence for a role of decreased dopamine D1DR availability in age-related dedifferentiation of striato-cortical function. Our findings are consistent with prior evidence linking PET markers of D1DR availability to functional coupling within cortico- cortical (Rieckmann et al, 2011; Roffman et al, 2016) and striato-cortical circuits (Johansson et al, 2023). At the single-neuron level, dopaminergic neuromodulation alters neuron’s input sensitivity, enhancing the signal-to-noise properties of brain function (Cools, 2019; Servan-Schreiber et al, 1990; Shine et al, 2021).…”

Dopamine D2/3Binding Potential Modulates Neural Signatures of Working Memory in a Load-Dependent Fashion

“…This finding is in contrast to a recent study by Roffman et al (2016), showing that striatal and extrastriatal DA D 1 selectively influence functional integrity of different large-scale systems during a WM task. Reasons for this discrepancy may stem from age differences across samples, differences in the kind of BOLD measures [BOLD amplitude in the current vs connectivity in the study by Roffman et al (2016)], or differences in the type of receptor binding examined and the ligands that are used (DA D 2/3 -sensitive raclopride in the current sample), which play different roles in facilitating WM performance. Although BOLD–DA associations were stronger in extrastriatal than striatal regions, these associations were similarly expressed for both striatal and extrastriatal regions within each group.…”

Reversible Photocontrol of Dopaminergic Transmission in Wild-Type Animals

“…This could be due to the diffusion (and therefore dilution) of azodopa within cortical tissue over time, and possibly to its metabolic washout and reuptake by synaptic terminals [ 58 ]. The increase of cortical activity by trans -azodopa is consistent with our results from functional studies in cell cultures and suggests that trans -azodopa may also act as a dopamine agonist in the mouse brain [ 59 ]. The general excitatory action of azodopa was modulated by UV light in individual neurons, some of which revealed a decrease in spiking activity while others increased it.…”

Dedifferentiation of caudate functional organization is linked to reduced D1 dopamine receptor availability and poorer memory function in aging

“…We further provide novel evidence for a role of decreased dopamine D1DR availability in age-related dedifferentiation of striato-cortical function. Our findings are consistent with prior evidence linking PET markers of D1DR availability to functional coupling within cortico- cortical (Rieckmann et al, 2011; Roffman et al, 2016) and striato-cortical circuits (Johansson et al, 2023). At the single-neuron level, dopaminergic neuromodulation alters neuron’s input sensitivity, enhancing the signal-to-noise properties of brain function (Cools, 2019; Servan-Schreiber et al, 1990; Shine et al, 2021).…”

Dopamine D2/3Binding Potential Modulates Neural Signatures of Working Memory in a Load-Dependent Fashion

“…This finding is in contrast to a recent study by Roffman et al (2016), showing that striatal and extrastriatal DA D 1 selectively influence functional integrity of different large-scale systems during a WM task. Reasons for this discrepancy may stem from age differences across samples, differences in the kind of BOLD measures [BOLD amplitude in the current vs connectivity in the study by Roffman et al (2016)], or differences in the type of receptor binding examined and the ligands that are used (DA D 2/3 -sensitive raclopride in the current sample), which play different roles in facilitating WM performance. Although BOLD–DA associations were stronger in extrastriatal than striatal regions, these associations were similarly expressed for both striatal and extrastriatal regions within each group.…”

Reversible Photocontrol of Dopaminergic Transmission in Wild-Type Animals

“…This could be due to the diffusion (and therefore dilution) of azodopa within cortical tissue over time, and possibly to its metabolic washout and reuptake by synaptic terminals [ 58 ]. The increase of cortical activity by trans -azodopa is consistent with our results from functional studies in cell cultures and suggests that trans -azodopa may also act as a dopamine agonist in the mouse brain [ 59 ]. The general excitatory action of azodopa was modulated by UV light in individual neurons, some of which revealed a decrease in spiking activity while others increased it.…”

Dedifferentiation of caudate functional organization is linked to reduced D1 dopamine receptor availability and poorer memory function in aging

“…We further provide novel evidence for a role of decreased dopamine D1DR availability in age-related dedifferentiation of striato-cortical function. Our findings are consistent with prior evidence linking PET markers of D1DR availability to functional coupling within cortico- cortical (Rieckmann et al, 2011; Roffman et al, 2016) and striato-cortical circuits (Johansson et al, 2023). At the single-neuron level, dopaminergic neuromodulation alters neuron’s input sensitivity, enhancing the signal-to-noise properties of brain function (Cools, 2019; Servan-Schreiber et al, 1990; Shine et al, 2021).…”