Dopamine and norepinephrine turnover in various regions of the rat brain after chronic manganese chloride administration

Iron-Responsive Olfactory Uptake of Manganese Improves Motor Function Deficits Associated with Iron Deficiency

“…Under our study conditions, DAT levels were the same in control and iron-deficient rats, but protein levels were reduced by olfactory manganese exposure in both groups. Similar effects of manganese exposure have been reported in studies of chronic administration by diet [29] or injection [30]. Our study indicates olfactory administration of manganese can also down-regulate DAT, possibly in a more acute manner.…”

Iron-Responsive Olfactory Uptake of Manganese Improves Motor Function Deficits Associated with Iron Deficiency

“…Under our study conditions, DAT levels were the same in control and iron-deficient rats, but protein levels were reduced by olfactory manganese exposure in both groups. Similar effects of manganese exposure have been reported in studies of chronic administration by diet [29] or injection [30]. Our study indicates olfactory administration of manganese can also down-regulate DAT, possibly in a more acute manner.…”

Manganese Inhalation as a Parkinson Disease Model

“…Contrary to previous reports [12, 14, 18, 23, 42–44, 57, 58], we found an important loss of TH-positive neurons as shown in Figures 8 and 9, exhibiting a pattern very similar to that observed in PD patients; according to our findings, some authors have been reported neurochemical changes in human and animal Mn intoxication including the reduction in DA levels and TH + immunoreactivity in the caudate nucleus, putamen, and SN [7, 8, 21, 27, 54–56]. In this way, it has been hypothesized that Mn interacts with catechols specific to dopaminergic neurons so as to rapidly deplete them and render such cells no longer viable [34, 66].…”

Transport and Control of Manganese Ions in the Central Nervous System

“…Concentrations of Mn in the substantia nigra and caudateputamen have been associated with decreases in the striatal dopamine concentration in both the rat and the monkey (Bird et al, 1984;Bonilla and Diez-Ewald, 1974). Our results extend previous investigations (Autissier et al, 1982;Bird et al, 1984;Bonilla and Diez-Ewald, 1974;Chandra et al, 1979) in which Mn concentration in the ventral mesencephalon was associated with decreased dopamine levels in the caudate-putamen. This suggests that Mn may inhibit dopamine production or dopamine storage and/or reduce the number of neurons in the substantia nigra.…”

Iron-Responsive Olfactory Uptake of Manganese Improves Motor Function Deficits Associated with Iron Deficiency

“…Under our study conditions, DAT levels were the same in control and iron-deficient rats, but protein levels were reduced by olfactory manganese exposure in both groups. Similar effects of manganese exposure have been reported in studies of chronic administration by diet [29] or injection [30]. Our study indicates olfactory administration of manganese can also down-regulate DAT, possibly in a more acute manner.…”

Manganese Inhalation as a Parkinson Disease Model

“…Contrary to previous reports [12, 14, 18, 23, 42–44, 57, 58], we found an important loss of TH-positive neurons as shown in Figures 8 and 9, exhibiting a pattern very similar to that observed in PD patients; according to our findings, some authors have been reported neurochemical changes in human and animal Mn intoxication including the reduction in DA levels and TH + immunoreactivity in the caudate nucleus, putamen, and SN [7, 8, 21, 27, 54–56]. In this way, it has been hypothesized that Mn interacts with catechols specific to dopaminergic neurons so as to rapidly deplete them and render such cells no longer viable [34, 66].…”

Transport and Control of Manganese Ions in the Central Nervous System

“…Concentrations of Mn in the substantia nigra and caudateputamen have been associated with decreases in the striatal dopamine concentration in both the rat and the monkey (Bird et al, 1984;Bonilla and Diez-Ewald, 1974). Our results extend previous investigations (Autissier et al, 1982;Bird et al, 1984;Bonilla and Diez-Ewald, 1974;Chandra et al, 1979) in which Mn concentration in the ventral mesencephalon was associated with decreased dopamine levels in the caudate-putamen. This suggests that Mn may inhibit dopamine production or dopamine storage and/or reduce the number of neurons in the substantia nigra.…”

Iron-Responsive Olfactory Uptake of Manganese Improves Motor Function Deficits Associated with Iron Deficiency

“…Under our study conditions, DAT levels were the same in control and iron-deficient rats, but protein levels were reduced by olfactory manganese exposure in both groups. Similar effects of manganese exposure have been reported in studies of chronic administration by diet [29] or injection [30]. Our study indicates olfactory administration of manganese can also down-regulate DAT, possibly in a more acute manner.…”

Manganese Inhalation as a Parkinson Disease Model

“…Contrary to previous reports [12, 14, 18, 23, 42–44, 57, 58], we found an important loss of TH-positive neurons as shown in Figures 8 and 9, exhibiting a pattern very similar to that observed in PD patients; according to our findings, some authors have been reported neurochemical changes in human and animal Mn intoxication including the reduction in DA levels and TH + immunoreactivity in the caudate nucleus, putamen, and SN [7, 8, 21, 27, 54–56]. In this way, it has been hypothesized that Mn interacts with catechols specific to dopaminergic neurons so as to rapidly deplete them and render such cells no longer viable [34, 66].…”

Transport and Control of Manganese Ions in the Central Nervous System

“…Concentrations of Mn in the substantia nigra and caudateputamen have been associated with decreases in the striatal dopamine concentration in both the rat and the monkey (Bird et al, 1984;Bonilla and Diez-Ewald, 1974). Our results extend previous investigations (Autissier et al, 1982;Bird et al, 1984;Bonilla and Diez-Ewald, 1974;Chandra et al, 1979) in which Mn concentration in the ventral mesencephalon was associated with decreased dopamine levels in the caudate-putamen. This suggests that Mn may inhibit dopamine production or dopamine storage and/or reduce the number of neurons in the substantia nigra.…”