Donor Site Morbidity in the Iliac Crest Bone Graft

Nm, Hill; Jg, Horne; Pa, Devane

doi:10.1046/j.1440-1622.1999.01674.x

Cited by 91 publications

(36 citation statements)

References 17 publications

(22 reference statements)

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“…Posterolateral intertransverse process fusion is a commonly performed procedure in the lumbar spine; however, the incidence of failure to achieve fusion has ranged from 5% to 45% in large series because of inadequate new bone mass caused by the limited mass of graft bone or poor surgical technique 5,10,41,46) . Although autogenous bone graft is the gold Standard for spinal fusion, there is a limit to its mass and complications are associated with bone harvest in as many as 20% of the patients, even in the hands of experienced surgeons 8,19,20,37,38) . In recent years, a variety of materials have been developed as alternatives to autogenous bone graft to avoid their disadvantages.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Risedronate on Posterior Lateral Spinal Fusion in a Rat Model

Gezici

Ergün

Gürel

et al. 2009

J Korean Neurosurg Soc

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Objective : To evaluate the potential effects of risedronate (RIS) which shows a higher anti-resorptive effect among bisphosphonates, after a posterolateral lumbar intertransverse process spinal fusion using both autograft and allograft in a rat model. Methods : A totoal of 28 Sprague-Dawley rats were randomized into 2 study groups. A posterolateral lumbar intertransverse process spinal fusion was peformed using both autograft and allograft in a rat model. Group I (control) received 0.1 mL of steril saline (placebo) and Group II (treatment) received risedronate, equivalent to human dose (10 µg/kg/week) for 10-weeks period.Results : The fusion rates as determined by manual palpation were 69% in the group I and 46% in the group II (p = 0.251). According to radiographic score, the spinal segment was considered to be fused radiographically in 7 (53%) of the 13 controls and 9 (69%) of the 13 rats treated with RIS (p = 0.851). The mean histological scores were 5.69 ± 0.13 and 3.84 ± 0.43 for the control and treatment groups, respectively. There was a significant difference between the both groups (p = 0.001). The mean bone density of the fusion masses was 86.9 ± 2.34 in the control group and 106.0 ± 3.54 in the RIS treatment group. There was a statistical difference in mean bone densities of the fusion masses comparing the two groups (p = 0.001). Conclusion : In this study, risedronate appears to delay bone fusion in a rat model. This occurs as a result of uncoupling the balanced osteoclastic and osteoblastic activity inherent to bone healing. These findings suggest that a discontinuation of risedronate postoperatively during acute fusion period may be warranted.

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Section: Discussionmentioning

confidence: 99%

The Effect of Risedronate on Posterior Lateral Spinal Fusion in a Rat Model

Gezici

Ergün

Gürel

et al. 2009

J Korean Neurosurg Soc

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“…Controlled cell death by apoptosis is recognized as an important component of embryogenesis and tissue morphogenesis, and, in adult skeletons it contributes substantially to physiological bone turnover, repair, and regeneration [1][2][3]. It is now generally accepted that the number of osteoblasts (OBs), the bone-forming cells, plays a critical role in bone turnover, and all major regulators of bone contribute to the regulation of OBs life span by modulating apoptosis [4].…”

Section: Introductionmentioning

confidence: 99%

Osteoblasts Display Different Responsiveness to TRAIL-Induced Apoptosis During Their Differentiation Process

Brunetti

Oranger

Carbone

et al. 2013

Cell Biochem Biophys

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Apoptosis can occur throughout the life span of osteoblasts (OBs), beginning from the early stages of differentiation and continuing throughout all stages of their working life. Here, we investigated the effects of tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) on normal human OBs showing for the first time that the expression of TRAIL receptors is modulated during OB differentiation. In particular, the TRAIL receptor ratio was in favor of the deaths because of the low expression of DcR2 in undifferentiated OBs, differently it was shifted toward the decoys in differentiated ones. Undifferentiated OBs treated with TRAIL showed reduced cell viability, whereas differentiated OBs displayed TRAIL resistance. The OB sensitiveness to TRAIL was due to the up-regulation of DR5 and the down-regulation of DcR2. The main death receptor involved in TRAIL-reduced OB viability was DR5 as demonstrated by the rescue of cell viability observed in the presence of anti-DR5 neutralizing antibody. Besides the ratio of TRAIL receptors, the sensitivity of undifferentiated OBs to TRAIL-cytotoxic effect was also associated with low mRNA levels of intracellular anti-apoptotic proteins, such as cFLIP, the activation of caspase-8 and -3, as well as the DNA fragmentation. This study suggests that apoptotic effect exerted by TRAIL/ TRAIL-receptor system on normal human OB is strictly dependent upon cell differentiation status.

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“…An autograft or autogeneous bone is osteoconductive, osteoinductive, and osteogenic, so it sets the gold standard for clinical bone repair (3). However, the application of an autograft is restricted by limited availability and donor-site complications, including infection and chronic pain (4,5). Allograft or allogenic bone has also been used as a skeletal substitute material.…”

mentioning

confidence: 99%

Bioreactor-based bone tissue engineering: The influence of dynamic flow on osteoblast phenotypic expression and matrix mineralization

Botchwey

Levine

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

268

195

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An important issue in tissue engineering concerns the possibility of limited tissue ingrowth in tissue-engineered constructs because of insufficient nutrient transport. We report a dynamic flow culture system using high-aspect-ratio vessel rotating bioreactors and 3D scaffolds for culturing rat calvarial osteoblast cells. 3D scaffolds were designed by mixing lighter-than-water (density, <1 g͞ml) and heavier-than-water (density, >1 g͞ml) microspheres of 85:15 poly(lactide-co-glycolide). We quantified the rate of 3D flow through the scaffolds by using a particle-tracking system, and the results suggest that motion trajectories and, therefore, the flow velocity around and through scaffolds in rotating bioreactors can be manipulated by varying the ratio of heavier-than-water to lighter-than-water microspheres. When rat primary calvarial cells were cultured on the scaffolds in bioreactors for 7 days, the 3D dynamic flow environment affected bone cell distribution and enhanced cell phenotypic expression and mineralized matrix synthesis within tissue-engineered constructs compared with static conditions. These studies provide a foundation for exploring the effects of dynamic flow on osteoblast function and provide important insight into the design and optimization of 3D scaffolds suitable in bioreactors for in vitro tissue engineering of bone.

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Donor Site Morbidity in the Iliac Crest Bone Graft

Abstract: Bone grafting from the iliac crest is a relatively benign procedure in terms of patient satisfaction, and the most significant morbidity is pain.

Cited by 91 publications

References 17 publications

The Effect of Risedronate on Posterior Lateral Spinal Fusion in a Rat Model

The Effect of Risedronate on Posterior Lateral Spinal Fusion in a Rat Model

Osteoblasts Display Different Responsiveness to TRAIL-Induced Apoptosis During Their Differentiation Process

Bioreactor-based bone tissue engineering: The influence of dynamic flow on osteoblast phenotypic expression and matrix mineralization

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