Domoic Acid: A Review of Its Cytogenotoxicity Within the One Health Approach

Abstract

In this review, we toxicologically assessed the naturally occurring toxin domoic acid. We used the One Health approach because the impact of domoic acid is potentiated by climate change and water pollution on one side, and reflected in animal health, food security, human diet, and human health on the other. In a changing environment, algal blooms are more frequent. For domoic acid production, the growth of Pseudo-nitzschia diatoms is of particular interest. They produce this toxin, whose capability of accumulation and biomagnification through the food web impacts other organisms in the ecosystem. Domoic acid targets nervous system receptors inducing amnestic shellfish poisoning, among other less severe health-related problems. However, the impact of domoic acid on non-target cells is rather unknown, so we reviewed the currently available literature on cytogenetic effects on human and animal cells. The results of different studies indicate that domoic acid has the potential to induce early molecular events, such as oxidative imbalance and DNA damage, thus posing an additional threat which needs to be thoroughly addressed and monitored in the future.

Discovery and Activity Evaluation of Quorum-Sensing Inhibitors from an Endophytic Bacillus Strain W10-B1 Isolated from Coelothrix irregularis

“…This study successfully isolated endophytic bacterial communities from the marine macroalga C. irregularis. Notably, while prior research has documented the taxonomy, morphology, geographical distribution, and representative toxic compounds (e.g., domoic acid) of C. irregularis, and molecular techniques (such as 16S rRNA gene sequencing) have characterized the composition of its endophytic microbiota, no studies have previously reported the successful cultivation and functional investigation of specific endophytic strains from this alga [20,21]. Our isolation work addresses this gap, thereby laying a foundation for exploring the chemical ecological roles of its endophytes and the pharmaceutical potential of their secondary metabolites [22].…”

Discovery and Activity Evaluation of Quorum-Sensing Inhibitors from an Endophytic Bacillus Strain W10-B1 Isolated from Coelothrix irregularis

“…This study successfully isolated endophytic bacterial communities from the marine macroalga C. irregularis. Notably, while prior research has documented the taxonomy, morphology, geographical distribution, and representative toxic compounds (e.g., domoic acid) of C. irregularis, and molecular techniques (such as 16S rRNA gene sequencing) have characterized the composition of its endophytic microbiota, no studies have previously reported the successful cultivation and functional investigation of specific endophytic strains from this alga [20,21]. Our isolation work addresses this gap, thereby laying a foundation for exploring the chemical ecological roles of its endophytes and the pharmaceutical potential of their secondary metabolites [22].…”

Children and Adolescents’ Susceptibility to Domoic Acid in Southern China: Preliminary Evidence Revealing Baseline Exposure Profiles and Multidimensional Influencing Factors

“…Acute exposure to DA in humans can cause amnesic shellfish poisoning, characterized by gastrointestinal symptoms such as vomiting and diarrhea, neurological effects including confusion, memory loss, and seizures, and in severe cases, coma or death [ 4 ]. Beyond acute toxicity, chronic low-dose exposure to DA represents a growing public health concern [ 5 ], especially as climate change and water pollution increase the frequency and geographic range of harmful algal blooms that produce DA [ 6 , 7 , 8 ].…”

Discovery and Activity Evaluation of Quorum-Sensing Inhibitors from an Endophytic Bacillus Strain W10-B1 Isolated from Coelothrix irregularis

“…This study successfully isolated endophytic bacterial communities from the marine macroalga C. irregularis. Notably, while prior research has documented the taxonomy, morphology, geographical distribution, and representative toxic compounds (e.g., domoic acid) of C. irregularis, and molecular techniques (such as 16S rRNA gene sequencing) have characterized the composition of its endophytic microbiota, no studies have previously reported the successful cultivation and functional investigation of specific endophytic strains from this alga [20,21]. Our isolation work addresses this gap, thereby laying a foundation for exploring the chemical ecological roles of its endophytes and the pharmaceutical potential of their secondary metabolites [22].…”

Children and Adolescents’ Susceptibility to Domoic Acid in Southern China: Preliminary Evidence Revealing Baseline Exposure Profiles and Multidimensional Influencing Factors

“…Acute exposure to DA in humans can cause amnesic shellfish poisoning, characterized by gastrointestinal symptoms such as vomiting and diarrhea, neurological effects including confusion, memory loss, and seizures, and in severe cases, coma or death [ 4 ]. Beyond acute toxicity, chronic low-dose exposure to DA represents a growing public health concern [ 5 ], especially as climate change and water pollution increase the frequency and geographic range of harmful algal blooms that produce DA [ 6 , 7 , 8 ].…”

Discovery and Activity Evaluation of Quorum-Sensing Inhibitors from an Endophytic Bacillus Strain W10-B1 Isolated from Coelothrix irregularis

“…This study successfully isolated endophytic bacterial communities from the marine macroalga C. irregularis. Notably, while prior research has documented the taxonomy, morphology, geographical distribution, and representative toxic compounds (e.g., domoic acid) of C. irregularis, and molecular techniques (such as 16S rRNA gene sequencing) have characterized the composition of its endophytic microbiota, no studies have previously reported the successful cultivation and functional investigation of specific endophytic strains from this alga [20,21]. Our isolation work addresses this gap, thereby laying a foundation for exploring the chemical ecological roles of its endophytes and the pharmaceutical potential of their secondary metabolites [22].…”

Children and Adolescents’ Susceptibility to Domoic Acid in Southern China: Preliminary Evidence Revealing Baseline Exposure Profiles and Multidimensional Influencing Factors

“…Acute exposure to DA in humans can cause amnesic shellfish poisoning, characterized by gastrointestinal symptoms such as vomiting and diarrhea, neurological effects including confusion, memory loss, and seizures, and in severe cases, coma or death [ 4 ]. Beyond acute toxicity, chronic low-dose exposure to DA represents a growing public health concern [ 5 ], especially as climate change and water pollution increase the frequency and geographic range of harmful algal blooms that produce DA [ 6 , 7 , 8 ].…”