Dominant psychiatric manifestations in Wilson's disease: A diagnostic and therapeutic challenge!

Srinivas, K; Sinha, Sanjib; Taly, AB; Prashanth, L.K.; Arunodaya, G. R.; Reddy, Y C Janardhana; Khanna, Sumant

doi:10.1016/j.jns.2007.09.009

Cited by 97 publications

(66 citation statements)

References 16 publications

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“…57 The latter has demonstrated one of the two predominant psychiatric manifestations, schizophreniaform-illness, suggesting an additional correlation of ESD and SZ. 58 Our other immune-related findings, C4A/C4B gene loci localize to the major histocompatibility complex (MHC) class III region on chromosome 6. The C4A/C4B gene encodes the basic form of complement factor 4, involved in the classical activation pathway of the complement system, a major effector of the innate and adaptive immune systems.…”

Section: Synapse and Neurotransmissionmentioning

confidence: 90%

An integrated genomic analysis of gene-function correlation on schizophrenia susceptibility genes

Chu

Liu

2010

J Hum Genet

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Schizophrenia is a highly complex inheritable disease characterized by numerous genetic susceptibility elements, each contributing a modest increase in risk for the disease. Although numerous linkage or association studies have identified a large set of schizophrenia-associated loci, many are controversial. In addition, only a small portion of these loci overlaps with the large cumulative pool of genes that have shown changes of expression in schizophrenia. Here, we applied a genomic gene-function approach to identify susceptibility loci that show direct effect on gene expression, leading to functional abnormalities in schizophrenia. We carried out an integrated analysis by cross-examination of the literature-based susceptibility loci with the schizophrenia-associated expression gene list obtained from our previous microarray study (Journal of Human Genetics (2009) 54: 665-75) using bioinformatic tools, followed by confirmation of gene expression changes using qPCR. We found nine genes (CHGB, SLC18A2, SLC25A27, ESD, C4A/C4B, TCP1, CHL1 and CTNNA2) demonstrate gene-function correlation involving: synapse and neurotransmission; energy metabolism and defense mechanisms; and molecular chaperone and cytoskeleton. Our findings further support the roles of these genes in genetic influence and functional consequences on the development of schizophrenia. It is interesting to note that four of the nine genes are located on chromosome 6, suggesting a special chromosomal vulnerability in schizophrenia.

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Section: Synapse and Neurotransmissionmentioning

confidence: 90%

An integrated genomic analysis of gene-function correlation on schizophrenia susceptibility genes

Chu

Liu

2010

J Hum Genet

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“…Typical psychiatric symptoms occur in almost 65% WD patients [29][30][31] and include personality disorders, mood disorders, cognitive impairment, psychosis, and less frequently other psychiatric alterations (anorexia, catatonia, substance abuse and others). 32 In up to 25% of WD patients psychiatric symptoms may be the initial disease presentation.…”

Section: Psychopathology In Wilson Diseasementioning

confidence: 99%

Encephalopathy in Wilson Disease: Copper Toxicity or Liver Failure?

Ferenci

Litwin

Seniów

et al. 2015

Journal of Clinical and Experimental Hepatology

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“…4 Twelve of these patients (24%) fulfilled the diagnostic criteria for a psychiatric condition: nine patients (18%) were diagnosed with bipolar disorder, two (4%) with major depression, and one (2%) with dysthymia. In another study, 5 11 out of 14 patients with WD had a mood disorder and three presented a schizophreniform-illness.…”

Section: Transtorno De Humor De Longa Data Antecedendo O Diagnóstico mentioning

confidence: 92%

Long-term mood disorder antedating the diagnosis of Wilson's disease

Vale

Caramelli

Teixeira

2011

Rev. Bras. Psiquiatr.

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Dominant psychiatric manifestations in Wilson's disease: A diagnostic and therapeutic challenge!

Cited by 97 publications

References 16 publications

An integrated genomic analysis of gene-function correlation on schizophrenia susceptibility genes

An integrated genomic analysis of gene-function correlation on schizophrenia susceptibility genes

Encephalopathy in Wilson Disease: Copper Toxicity or Liver Failure?

Long-term mood disorder antedating the diagnosis of Wilson's disease

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