volume 66, issue 7, P4540-4545 1992
DOI: 10.1128/jvi.66.7.4540-4545.1992
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Abstract: The 27-kDa Rex transacting protein appears to be essential for replication of human T-cell leukemia virus type I. Mutations introduced outside of the Rex RNA-binding domain-nucleolar localization signal display either wild-type activity or, conversely, yield dominant-negative proteins. We generated missense mutations in a particular domain of the Rex protein (amino acid residues 54 to 69) which is characterized by a cluster of dominant-negative mutants. Our results indicate that amino acids 57 to 67 are critic…

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