Dominant lethal study of α-asarone in male and female mice after sub-chronic treatment

Anti-Amyloidogenic Effects of Asarone Derivatives From Perilla frutescens Leaves Against Beta-Amyloid Aggregation and Nitric Oxide Production

“…Asarone derivatives including α- and β-asarone are major bioactive phytochemicals present in the Acorus species such as Acorus calamus Linn and Acorus gramineus Solander [32,33], and Guatteria gaumeri Greenman [34]. The wide range of pharmacological activities of asarone derivatives have been reported including antiepileptic [35], antidepressant [36], anxiolytic [37], neuroprotective [38], and hypolipidemic activities [39].…”

Volatile oil of Acori tatarinowii rhizoma: potential candidate drugs for mitigating dementia

“…Short-term exposure to α-Asarone caused reproductive toxicity, such as reduced sperm concentration, motility, and seminal vesicle weight in CF1 mice at high doses (30 mg/kg intraperitoneally for 5 days) ( Chamorro et al, 1998 ). However, long-term subacute toxicity studies (10 and 20 mg/kg, orally, 5 days per week for eight consecutive weeks) showed no significant effects on sperm count, testicular tissue morphology, testicular weight, or epididymal weight ( Chamorro et al, 1999 ). Debates persist regarding the genotoxicity of α-Asarone and β-Asarone.…”

α‐Asarone, β‐asarone, and γ‐asarone: Current status of toxicological evaluation

“…Embryolethality at doses ≥15 mg/kg bw/day and fetal malformations (hydrocephaly, extra-ribs, clubfeet, and cleft lips) at the highest dose of 60 mg/kg bw/day were detected (Salazar et al, 1992). Chamorro et al (1993Chamorro et al ( , 1998 and Chamorro, Salazar, Tamariz, Díaz, and Labarrios (1999) conducted three dominant lethal tests in mice and rats. Either male or female Wistar rats were treated with α-asarone in doses of 0, 5, 10, and 15 mg/kg bw/day for 5 days.…”

“…Chamorro et al (1993, 1998) and Chamorro, Salazar, Tamariz, Díaz, and Labarrios (1999) conducted three dominant lethal tests in mice and rats. Either male or female Wistar rats were treated with α‐asarone in doses of 0, 5, 10, and 15 mg/kg bw/day for 5 days.…”