Does Zinc Supplementation Increase the Risk of Prostate Cancer?

The redox biology of redox-inert zinc ions

“…Another article entitled "Why zinc should not be considered an antioxidant" points out that zinc is also a selenium antagonist, abolishing its anticarcinogenic effects and that additional zinc in the diet may be linked to an increase in skin cancer and that additional zinc in healthy human breast tissue increased the risk of later breast cancer development [175]. A similar observation was made for prostate cancer where the risk increased slightly when 2.5 times the recommended tolerable upper limit of 40 mg was supplemented in trials to prevent agerelated macular degeneration [176].…”

The redox biology of redox-inert zinc ions

“…Another article entitled "Why zinc should not be considered an antioxidant" points out that zinc is also a selenium antagonist, abolishing its anticarcinogenic effects and that additional zinc in the diet may be linked to an increase in skin cancer and that additional zinc in healthy human breast tissue increased the risk of later breast cancer development [175]. A similar observation was made for prostate cancer where the risk increased slightly when 2.5 times the recommended tolerable upper limit of 40 mg was supplemented in trials to prevent agerelated macular degeneration [176].…”

The Essential Toxin: Impact of Zinc on Human Health

“…Men with moderate to higher zinc intake may have a lower risk for prostate cancer, but the opposite may be true at extremely high doses and long-term supplementation [77]. A study by Leitzmann and colleagues examined the association between supplemental zinc intake and prostate cancer risk among 46,974 U.S. men.…”

Zinc Essentiality, Toxicity, and Its Bacterial Bioremediation: A Comprehensive Insight

“…In human health, though Zn is well-reported to be essential for the regulation of most biological functions, its excessive levels are implicated in the causation and development of prostate cancer ( Zaichick et al, 1997 ; Costello and Franklin, 1998 ), which is associated with regulating Zip1, a Zn transporter attributed to its accumulation and acquisition in prostate cells ( Costello et al, 1999 ; Franklin et al, 2005 ). Though men having a moderate to high level of Zn intake may be reported to face a lower risk of prostate cancer, exceedingly high concentrations or perpetual Zn intake can result otherwise ( Jarrard, 2005 ; Plum et al, 2010 ).…”

The redox biology of redox-inert zinc ions

“…Another article entitled "Why zinc should not be considered an antioxidant" points out that zinc is also a selenium antagonist, abolishing its anticarcinogenic effects and that additional zinc in the diet may be linked to an increase in skin cancer and that additional zinc in healthy human breast tissue increased the risk of later breast cancer development [175]. A similar observation was made for prostate cancer where the risk increased slightly when 2.5 times the recommended tolerable upper limit of 40 mg was supplemented in trials to prevent agerelated macular degeneration [176].…”

The Essential Toxin: Impact of Zinc on Human Health

“…Men with moderate to higher zinc intake may have a lower risk for prostate cancer, but the opposite may be true at extremely high doses and long-term supplementation [77]. A study by Leitzmann and colleagues examined the association between supplemental zinc intake and prostate cancer risk among 46,974 U.S. men.…”

Zinc Essentiality, Toxicity, and Its Bacterial Bioremediation: A Comprehensive Insight

“…In human health, though Zn is well-reported to be essential for the regulation of most biological functions, its excessive levels are implicated in the causation and development of prostate cancer ( Zaichick et al, 1997 ; Costello and Franklin, 1998 ), which is associated with regulating Zip1, a Zn transporter attributed to its accumulation and acquisition in prostate cells ( Costello et al, 1999 ; Franklin et al, 2005 ). Though men having a moderate to high level of Zn intake may be reported to face a lower risk of prostate cancer, exceedingly high concentrations or perpetual Zn intake can result otherwise ( Jarrard, 2005 ; Plum et al, 2010 ).…”

The redox biology of redox-inert zinc ions

“…Another article entitled "Why zinc should not be considered an antioxidant" points out that zinc is also a selenium antagonist, abolishing its anticarcinogenic effects and that additional zinc in the diet may be linked to an increase in skin cancer and that additional zinc in healthy human breast tissue increased the risk of later breast cancer development [175]. A similar observation was made for prostate cancer where the risk increased slightly when 2.5 times the recommended tolerable upper limit of 40 mg was supplemented in trials to prevent agerelated macular degeneration [176].…”

The Essential Toxin: Impact of Zinc on Human Health

“…Men with moderate to higher zinc intake may have a lower risk for prostate cancer, but the opposite may be true at extremely high doses and long-term supplementation [77]. A study by Leitzmann and colleagues examined the association between supplemental zinc intake and prostate cancer risk among 46,974 U.S. men.…”

Zinc Essentiality, Toxicity, and Its Bacterial Bioremediation: A Comprehensive Insight

“…In human health, though Zn is well-reported to be essential for the regulation of most biological functions, its excessive levels are implicated in the causation and development of prostate cancer ( Zaichick et al, 1997 ; Costello and Franklin, 1998 ), which is associated with regulating Zip1, a Zn transporter attributed to its accumulation and acquisition in prostate cells ( Costello et al, 1999 ; Franklin et al, 2005 ). Though men having a moderate to high level of Zn intake may be reported to face a lower risk of prostate cancer, exceedingly high concentrations or perpetual Zn intake can result otherwise ( Jarrard, 2005 ; Plum et al, 2010 ).…”