Does treatment of schizophrenia with antipsychotic medications eliminate or reduce psychosis? A 20-year multi-follow-up study

Harrow, Martin; Jobe, Thomas H.; Faull, Robert

doi:10.1017/s0033291714000610

Cited by 104 publications

(82 citation statements)

References 60 publications

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“…Current studies continue to question the optimistic claims made for both antidepressants and antipsychotics (e.g. [34,35]) and are covered broadly in the media (e.g. [36,37]).…”

Section: Discussionmentioning

confidence: 99%

The public debate on psychotropic medication and changes in attitudes 1990–2011

Angermeyer

Auwera

Matschinger

et al. 2015

Eur Arch Psychiatry Clin Neurosci

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Over the last 25 years, the appraisal of psychotropic drugs within the scientific community and their representation in the media has changed considerably. The initial optimism in the wake of the introduction of second-generation drugs has increasingly made room for a more critical evaluation of alleged advantages of these drugs. The question arises as to what extent this is reflected in similar changes in the public's attitudes towards psychiatric medication. Three representative population surveys on attitudes towards psychotropic medication were carried out in Germany in 1990 (N = 3075), 2001 (N = 2610) and 2011 (N = 1223), using the same sampling procedure, interview mode and instrument for assessing attitudes. In order to disentangle time-related effects, an age-period-cohort analysis was performed. Over the time period of 21 years, the German public's evaluation of psychotropic medication has become markedly more favourable. This change was mostly due to a period effect, i.e. concurrent influences of the social environment people are exposed to. Changes were much more pronounced in the 1990s, while over the following decade only a small, although statistically significant, increase in the favourable appraisal of medication was found. Age and birth cohort had only a minor effect on public attitudes. Our findings suggest that changes in the evaluation of the effects of psychotropic drugs within the psychiatric community and their representation in the media also affect public opinion. Given the ongoing debate about side effects and efficacy of psychiatric medication, future changes of public opinion can be expected.

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“…Current studies continue to question the optimistic claims made for both antidepressants and antipsychotics (e.g. [34,35]) and are covered broadly in the media (e.g. [36,37]).…”

Section: Discussionmentioning

confidence: 99%

The public debate on psychotropic medication and changes in attitudes 1990–2011

Angermeyer

Auwera

Matschinger

et al. 2015

Eur Arch Psychiatry Clin Neurosci

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“…Given this discrepancy, how can radical and urgent reform be by-passed? No other branch of medicine could tolerate such a gross known discrepancy in clinical outcomes (Harrow, 2014). Worse, when the Harvard Centre for Ethics, no less, lays out a succinct, undeniable case of institutional corruption (Whitaker & Cosgrove, 2015), any other profession would surely pause for thought.…”

Section: The Trauma Still Hurtsmentioning

confidence: 99%

The Scientific Evidence That “Intent” Is Vital for Healthcare

Johnson¹

2017

OJPP

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THINKING cannot occur without electrons, a point philosophically, scientifically and irrefutably confirmed for all, by the Electroencephalogram (EEG). However for 100 years, electrons and their ilk have scrupulously obeyed the Uncertainty Principle. Probability rules. The way human beings reason is by concluding that if event B is seen to follow cause A, it will do so again tomorrow-electrons don't even support this today. Hume's critique of causality which Kant failed to refute, gains traction from Quantum Mechanics. Despite needing to insert the word "probably" into every human reasoning, healthcare demonstrates an element of unexpected stability. The label "intent" is expanded to cover this anomaly, endeavouring to highlight how living cells cope with the impact of this unknowability, this Uncertainty. Mental health follows suit, though here the uncertainty comes additionally from "blockage" of the frontal lobes consequent upon trauma/terror. The collapse of today's psychiatry is pathognomonic, and medically solipsistic. The role of "intent", and its close relative, consent, are offered as remedies, not only for mental disease, relabelled here "social defeat", but also for the global disease of violence, culminating in the biggest health threat of them all, thermonuclear war.

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“…In an interesting study, Harrow et al [7] attempted to address an important issue in the treatment of schizophrenia - the lack of evidence of long-term (>3 years) treatment with antipsychotic medication and whether antipsychotics reduce or eliminate psychosis in long-term treatment. At a relatively early phase of their disorder, 139 patients were assessed prospectively and then reassessed at 5 or 6 subsequent follow-ups over the next 20 years by trained interviewers who were not informed of their diagnosis or of the results of their previous follow-up examinations.…”

Section: Psychosis and Schizophreniamentioning

confidence: 99%

Clinical Factor 2014

Balon

2015

Psychother Psychosom

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Does treatment of schizophrenia with antipsychotic medications eliminate or reduce psychosis? A 20-year multi-follow-up study

Cited by 104 publications

References 60 publications

The public debate on psychotropic medication and changes in attitudes 1990–2011

The public debate on psychotropic medication and changes in attitudes 1990–2011

The Scientific Evidence That “Intent” Is Vital for Healthcare

Clinical Factor 2014

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