Does Tinnitus Fill in the Gap Using Electrophysiology? A Scoping Review

Duda, Victoria; Scully, Olivia Jane; Baillargeon, Marie-Sarah; Hébert, Sylvie

doi:10.1016/j.otc.2020.03.006

Cited by 4 publications

(2 citation statements)

References 37 publications

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“…When tinnitus develops, animals fail GPIAS (a lack of significant suppression between no gap and gap trials within an animal). Although the underlying mechanism of this phenomenon is still under debate (Eggermont, 2013(Eggermont, , 2016Galazyuk and Hébert, 2015;Salloum et al, 2016) the GPIAS test has been verified against psychophysical tests for tinnitus in animals (Turner et al, 2006) and is supported by some data from the human tinnitus population Hébert, 2013, 2020;Duda et al, 2020), although others have debated its use (Campolo et al, 2013;Morse and Vander Werff, 2019). As a lack of significant suppression in the GPIAS test could be due to hearing loss, i.e., the animals not being able to hear the background noise and hence not detecting the gap, or alternatively an issue with startle circuitry, PPI is implemented alongside the GPIAS to exclude these possibilities.…”

Section: Behavioral Tests For Tinnitusmentioning

confidence: 90%

Excitatory Repetitive Transcranial Magnetic Stimulation Over Prefrontal Cortex in a Guinea Pig Model Ameliorates Tinnitus

et al. 2021

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Tinnitus, a phantom auditory perception that can seriously affect quality of life, is generally triggered by cochlear trauma and associated with aberrant activity throughout the auditory pathways, often referred to as hyperactivity. Studies suggest that non-auditory structures, such as prefrontal cortex (PFC), may be involved in tinnitus generation, by affecting sensory gating in auditory thalamus, allowing hyperactivity to reach the cortex and lead to perception. Indeed, human studies have shown that repetitive transcranial magnetic stimulation (rTMS) of PFC can alleviate tinnitus. The current study investigated whether this therapeutic effect is achieved through inhibition of thalamic hyperactivity, comparing effects of two common clinical rTMS protocols with sham treatment, in a guinea pig tinnitus model. Animals underwent acoustic trauma and once tinnitus developed were treated with either intermittent theta burst stimulation (iTBS), 20 Hz rTMS, or sham rTMS (10 days, 10 min/day; weekdays only). Tinnitus was reassessed and extracellular recordings of spontaneous tonic and burst firing rates in auditory thalamus made. To verify effects in PFC, densities of neurons positive for calcium-binding proteins, calbindin and parvalbumin, were investigated using immunohistochemistry. Both rTMS protocols significantly reduced tinnitus compared to sham. However, spontaneous tonic firing decreased following 20 Hz stimulation and increased following iTBS in auditory thalamus. Burst rate was significantly different between 20 Hz and iTBS stimulation, and burst duration was increased only after 20 Hz treatment. Density of calbindin, but not parvalbumin positive neurons, was significantly increased in the most dorsal region of PFC indicating that rTMS directly affected PFC. Our results support the involvement of PFC in tinnitus modulation, and the therapeutic benefit of rTMS on PFC in treating tinnitus, but indicate this is not achieved solely by suppression of thalamic hyperactivity.

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Section: Behavioral Tests For Tinnitusmentioning

confidence: 90%

Excitatory Repetitive Transcranial Magnetic Stimulation Over Prefrontal Cortex in a Guinea Pig Model Ameliorates Tinnitus

et al. 2021

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“…In addition, when classifying tinnitus and judging the efficacy of drugs, an objective index is more helpful to the judgment of experimental results [ 4 ]. Moreover, prelingual children and patients with low-functioning behavioral abilities or cognition [ 5 ] need to be tested by the objective method.…”

Section: Introductionmentioning

confidence: 99%

Objective Detection of Tinnitus Based on Electrophysiology

Fan

2022

Brain Sciences

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Tinnitus, a common disease in the clinic, is associated with persistent pain and high costs to society. Several aspects of tinnitus, such as the pathophysiology mechanism, effective treatment, objective detection, etc., have not been elucidated. Any change in the auditory pathway can lead to tinnitus. At present, there is no clear and unified mechanism to explain tinnitus, and the hypotheses regarding its mechanism include auditory plasticity theory, cortical reorganization theory, dorsal cochlear nucleus hypothesis, etc. Current theories on the mechanism of tinnitus mainly focus on the abnormal activity of the central nervous system. Unfortunately, there is currently a lack of objective diagnostic methods for tinnitus. Developing a method that can detect tinnitus objectively is crucial, only in this way can we identify whether the patient really suffers from tinnitus in the case of cognitive impairment or medical disputes and the therapeutic effect of tinnitus. Electrophysiological investigations have prompted the development of an objective detection of tinnitus by potentials recorded in the auditory pathway. However, there is no objective indicator with sufficient sensitivity and specificity to diagnose tinnitus at present. Based on recent findings of studies with various methods, possible electrophysiological approaches to detect the presence of tinnitus have been summarized. We analyze the change of neural activity throughout the auditory pathway in tinnitus subjects and in patients with tinnitus of varying severity to find available parameters in these methods, which is helpful to further explore the feasibility of using electrophysiological methods for the objective detection of tinnitus.

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Current therapeutic trends for tinnitus cure and control – a scoping review

Va¹,

Patel²,

Mehta

et al. 2021

Preprint

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Background: The inherent complexities of conditions such as tinnitus with cause and mechanism not known, presents a lack of high-level evidence to make an inference on the treatment approaches. A comprehensive review cannot be performed owing to an insufficient number of trials. Hence a scoping review approach was adopted to provide a broad overview of approaches for tinnitus management. Objective: To review the current evidence on prevalent treatment strategies used for tinnitus management and determine barriers and facilitators for the adoption of treatment approaches in developed and developing countries. Methods: The present scoping review was performed in compliance with the PRISMA ScR checklist. A literature search was carried out in PubMed, Scopus, Google Scholar, and Cochrane databases. Articles published between 2010-2021 mentioning treatment strategies were included. However, therapies concentrating on symptomatic management were excluded. Evidence with the highest scientific hierarchy such as systematic reviews (SRs) and randomized-controlled trials (RCTs) was considered. The context for the ScR was study-region based and included studies from high-income and low and middle-income countries (HICs, LMICs) Results: A total of 20 records were included with 11 SRs and 9 RCTs. Non-pharmacological interventions demonstrated moderate efficacy, including transcranial magnetic- (TMS) and direct current stimulation (tDCS), hearing aids (combined with a sound generator or alone). No specific drug was found to have a mode of action about the target root cause due to a lack of clinical knowledge. Most of the trials used the same tools for tinnitus severity. Conclusion: Although several scoping reviews are published with an exclusive focus on individual therapies, authors recommend an umbrella review of systematic reviews to generate evidence-based practice consensus for tinnitus.

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Does Tinnitus Fill in the Gap Using Electrophysiology? A Scoping Review

Cited by 4 publications

References 37 publications

Excitatory Repetitive Transcranial Magnetic Stimulation Over Prefrontal Cortex in a Guinea Pig Model Ameliorates Tinnitus

Excitatory Repetitive Transcranial Magnetic Stimulation Over Prefrontal Cortex in a Guinea Pig Model Ameliorates Tinnitus

Objective Detection of Tinnitus Based on Electrophysiology

Current therapeutic trends for tinnitus cure and control – a scoping review

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