Does sugammadex suppress allergic inflammation due to rocuronium in animal model of rat?

Abstract

Introduction and Objectives: There are a few reports in the literature about the successful use of sugammadex in the treatment of hypersensitivity reactions caused by rocuronium; however, the pathophysiological mechanism is still unknown. This study aims to investigate the changes caused by rocuronium in the lung and the effect of sugammadex on these changes with bio-chemical, light microscopic and immunohistochemical parameters on a rat model.Materials and Methods: For the study, 28-male Sprague-Dawley rats were randomly divided, seven of each, into four groups. Group C (control) received only 0. 9 % NaCl without any drug. Group R received rocuronium alone 1mg/kg. Group S received sugammadex alone 96 mg/kg. Group RS received rocuronium 1mg/kg and sugammadex 96 mg/kg. After 24 h later, the ani-mals were sacrificed and their tissues were removed. Biochemical (IgE/CRP), light microscopic and immunohistochemical findings were recorded.Results: Immunoglobulin E and CRP levels, peribronchial, alveolar septal lymphocytic infiltra-tion, thickening of the alveolar membranes and bleeding sites in Group R were significantly higher than all the other groups. In Group RS, while these parameters were significantly lower than that of Group R and Group S, it was significantly higher than that of Group C. Total mast cells and tryptase-positive mast cells counts were significantly higher in Group R than in all other groups. In Group RS, these parameters were statistically lower than that of Group R and Group S, but higher than that of Group C.Conclusions: This study shows that allergic inflammatory changes due to rocuronium in the lungs of rats are reduced with sugammadex. These results support cases of anaphylaxis due to rocuronium which improved with sugammadex.

Potential Neuroprotective Role of Sugammadex: A Clinical Study on Cognitive Function Assessment in an Enhanced Recovery After Cardiac Surgery Approach and an Experimental Study

“…Furthermore, as stated earlier, peripheral parameters affect the regulation of neuroinflammation. SG has been reported to affect peripheral parameters, such as coagulation reduction ( Kang J. H. et al, 2020 ; Kang W. S. et al, 2020 ), return of neuromuscular signals ( Biricik et al, 2019 ), and peripheral inflammation ( Yeşiltaş et al, 2021 ). Moreover, plasma inflammatory and neuronal injury markers have been reported by surgery and anesthesia procedures ( Subramaniyan and Terrando, 2019 ).…”

Role of sugammadex in the treatment of anaphylaxis due to rocuronium in children: Extrapolation from adult and animal reports

“…Various animal studies have attempted to define the effect of sugammadex on the inflammatory and immunologic reactions in rocuronium‐induced allergic reactions. Using biochemical, light microscopy, and immunohistochemical parameters, Yesilitas et al 28 investigated the impact of sugammadex on changes caused by rocuronium in the lungs of Sprague–Dawley rats. The rats were evenly divided into 4 study cohorts with the control group (C) receiving saline, group 2 receiving rocuronium (R), group 3 receiving sugammadex (S), and group 4 receiving both rocuronium and sugammadex (RS).…”

Possible effects of some anaesthetic agents in rat hepatotoxicity: Histological and biochemical study

“…The experimental procedures of the present study were approved by the Adıyaman University, Animal Experiments Local Ethics Committee with the report of ADYU-HADYEK 2019/032. In our study, 32 adult Sprague -Dawley male rats weighing 300-350 g were used (20,21). The rats were monitored daily under favorable conditions (Room temperature: 22-25 °C and humidity: 50-55%) with standard pellet diet and water ad libitum.…”