Does social distancing impact pediatric upper airway infections? An observational controlled study and a brief literature review

Franchella, Sebastiano; Favaretto, Niccolò; Frigo, Annachiara; Franz, Leonardo; Pilo, Simona; Mularoni, Francesca; Marciani, S.; Nicolai, Piero; Marioni, Gino; Cazzador, Diego

doi:10.1016/j.amjoto.2023.103801

Cited by 6 publications

(3 citation statements)

References 30 publications

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“…Several studies have shown that the NPIs put in place in response to the COVID-19 pandemic were associated with a decreased incidence of previous common respiratory pathogens, such as in uenza and streptococcus pneumonia [6,7]. This association between NPIs and the incidence of infectious disease has also been observed for pediatric patients e.g., with respect to viral respiratory infections [8,9] or middle ear infections and effusion [10]. Interestingly, there are currently several reports of an increased incidence of common infectious diseases following the successive cessation of NTIs after the end of the pandemic [11].…”

Section: Introductionmentioning

confidence: 88%

Dynamics of upper respiratory tract infections before, during, and after the COVID-19 pandemic in Germany: a cross-sectional study of 2,167,453 outpatients

Loosen

Plendl

Konrad

et al. 2023

Preprint

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Background Although the burden of the COVID-19 pandemic on global healthcare systems is declining, long-term sequelae such as long COVID syndrome and other disease dynamics not primarily associated with COVID-19 remain a challenge. Recent data suggest that the incidence of non-COVID upper respiratory tract infections (URTI) is increasing sharply in the post-pandemic period, but there is a lack of real-world data from Germany in this respect. Methods This cross-sectional study evaluated the number of patients with a diagnosis of URTI from the Disease Analyzer database (IQVIA) between January 2019 and December 2022. The number of UTRI diagnoses per practice and the duration of sick leave per patient were compared over time. Results A total of 1,872,935 individuals (1,403,907 patients from general practices (GP) and 469,028 patients from pediatric offices) were included, 48% of whom were female. The number of URTI patients per practice was significantly higher in 2022 than in 2019 (732 vs. 464, 58%, p < 0.001) and this was observed for both women (56%, p < 0.001) and men (60%, p < 0.001). The post-pandemic increase in the number of URTI diagnoses correlated with age and was highest in the age group between 18–30 years (22%, p < 0.001) and lowest in older patients > 70 years (3%). In pediatric patients (< 18 years), the increase was highest in the age group ≤ 5 years (89%). Both the number of patients per practice on sick leave due to URTI (184 vs. 92) and the average duration of sick leave (+ 2 days) increased from 2019 to 2022. Conclusion Our data suggest a dramatic increase in the incidence of URTI among all demographic subgroups in Germany between 2019 and 2022, which was associated with a tremendous impact on socioeconomic variables such as the frequency or duration of sick leave. These data could be of great importance in current pandemic management and the management of future pandemics.

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Section: Introductionmentioning

confidence: 88%

Dynamics of upper respiratory tract infections before, during, and after the COVID-19 pandemic in Germany: a cross-sectional study of 2,167,453 outpatients

Loosen

Plendl

Konrad

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Dieser Zusammenhang zwischen NPIs und dem Auftreten von Infektionskrankheiten wurde auch bei pädiatrischen Patienten beobachtet, z. B. bei viralen Atemwegsinfektionen (8,9) oder Mittelohrentzündungen (10). Interessanterweise gibt es derzeit mehrere Berichte über eine erhöhte Inzidenz häufiger Infektionskrankheiten nach dem sukzessiven Absetzen von NPI nach Pandemieende (11).…”

Section: Zusammenfassungunclassified

Zunahme von Infektionen der oberen Atemwege nach der Covid-19-Pandemie

Kostev,

Plendl,

Kluge MS

et al. 2024

MVF

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This cross-sectional study evaluated the number of patients with a diagnosis of upper respiratory tract infections (URTI) and with antibiotic prescriptions from the Disease Analyzer database (IQVIA) between January 2019 and December 2022. The number of patients with UTRI diagnoses and antibiotic prescriptions per practice and the duration of sick leave per patient were compared over time. A total of 1,403,907 patients from general practices (GP) were included, 48% of whom were female. The number of URTI patients per practice was significantly higher in 2022 than in 2019 (732 vs. 464, 58%, p<0.001) and this was observed for both women (56%, p<0.001) and men (60%, p<0.001). The post-pandemic increase in the number of URTI diagnoses correlated with age and was highest in the age group between 18–30 years (22%, p<0.001) and lowest in older patients >70 years (3%). Both the number of patients per practice on sick leave due to URTI (184 vs. 92) and the average duration of sick leave (+2 days) increased from 2019 to 2022. Our data suggest a dramatic increase in the incidence of URTI among all demographic subgroups in Germany between 2019 and 2022, which was associated with a tremendous impact on socioeconomic variables such as the frequency or duration of sick leave. These data could be of great importance in current pandemic management and the management of future pandemics.

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“… 6 , 7 This association between NPIs and the incidence of infectious disease has also been observed for pediatric patients, for example, with respect to viral respiratory infections 8 , 9 or middle ear infections and effusion. 10 Interestingly, there are currently several reports of an increased incidence of common infectious diseases following the successive cessation of NTIs after the end of the pandemic. 11 This has been associated with high levels of sick leave, which in turn poses major socio-economic challenges.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Upper Respiratory Tract Infections Before, During, and After the COVID-19 Pandemic in Germany: A Cross-Sectional Study of 2 167 453 Outpatients

Loosen,

Plendl,

Konrad

et al. 2023

J Prim Care Community Health

View full text Add to dashboard Cite

Background: Although the burden of the COVID-19 pandemic on global healthcare systems is declining, long-term sequelae such as long COVID syndrome and other disease dynamics not primarily associated with COVID-19 remain a challenge. Recent data suggest that the incidence of non-COVID upper respiratory tract infections (URTI) is increasing sharply in the post-pandemic period, but there is a lack of real-world data from Germany in this respect. Methods: This cross-sectional study evaluated the number of patients with a diagnosis of URTI from the Disease Analyzer database (IQVIA) between January 2019 and December 2022. The number of UTRI diagnoses per practice and the duration of sick leave per patient were compared over time. Results: A total of 1 872 935 individuals (1 403 907 patients from general practices (GP) and 469 028 patients from pediatric offices) were included, 48% of whom were female. The number of URTI patients per practice was significantly higher in 2022 than in 2019 (732 vs 464, 58%, P < .001), and this was observed for both women (56%, P < .001) and men (60%, P < .001). The post-pandemic increase in the number of URTI diagnoses correlated with age and was highest in the age group between 18 and 30 years (22%, P < .001) and lowest in older patients >70 years (3%). In pediatric patients (<18 years), the increase was highest in the age group ≤5 years (89%). Both the number of patients per practice on sick leave due to URTI (184 vs 92) and the average duration of sick leave (+2 days) increased from 2019 to 2022. Conclusion: Our data suggest a dramatic increase in the incidence of URTI among all demographic subgroups in Germany between 2019 and 2022, which was associated with a tremendous impact on socioeconomic variables such as the frequency or duration of sick leave. These data could be of great importance in current pandemic management and the management of future pandemics.

show abstract

Does social distancing impact pediatric upper airway infections? An observational controlled study and a brief literature review

Cited by 6 publications

References 30 publications

Dynamics of upper respiratory tract infections before, during, and after the COVID-19 pandemic in Germany: a cross-sectional study of 2,167,453 outpatients

Dynamics of upper respiratory tract infections before, during, and after the COVID-19 pandemic in Germany: a cross-sectional study of 2,167,453 outpatients

Zunahme von Infektionen der oberen Atemwege nach der Covid-19-Pandemie

Prevalence of Upper Respiratory Tract Infections Before, During, and After the COVID-19 Pandemic in Germany: A Cross-Sectional Study of 2 167 453 Outpatients

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