2005
DOI: 10.1111/j.1365-2222.2005.02312.x
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Abstract: The scoring system developed appears to improve the sensitivity of assessment of reactions induced by DBPCFC. This is the first prospective study showing an association between PsIgE levels and clinical reactivity in DBPCFC, an effect that is more pronounced in non-asthmatics. This finding has important implications for the clinical care of subjects with food allergy. There is a poor correlation between the severity of reported reactions in the community and the severity of reaction elicited during low-dose DB… Show more

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Cited by 134 publications
(146 citation statements)
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“…A history of asthma appears to be a major risk factor for severe or lifethreatening anaphylactic reactions to food (32,(50)(51)(52), and many fatal cases of anaphylaxis occur in allergic patients with asthma (21,23,53). Additional risk factors that should prompt consideration of prescribing AAIs include peanut/tree nut allergy, allergic reactions to small quantities of a food, high levels of atopy, food allergy in teenagers and living remote from a medical facility (21,53,54). Expansion of existing national and international databases is expected to refine the quality of data and allow a more systematic approach to identifying the patient at risk of anaphylaxis and requiring an AAI (55).…”
Section: Lack Of Availability Of Aais For Patients At Risk Of Anaphylmentioning
confidence: 99%
“…A history of asthma appears to be a major risk factor for severe or lifethreatening anaphylactic reactions to food (32,(50)(51)(52), and many fatal cases of anaphylaxis occur in allergic patients with asthma (21,23,53). Additional risk factors that should prompt consideration of prescribing AAIs include peanut/tree nut allergy, allergic reactions to small quantities of a food, high levels of atopy, food allergy in teenagers and living remote from a medical facility (21,53,54). Expansion of existing national and international databases is expected to refine the quality of data and allow a more systematic approach to identifying the patient at risk of anaphylaxis and requiring an AAI (55).…”
Section: Lack Of Availability Of Aais For Patients At Risk Of Anaphylmentioning
confidence: 99%
“…Previous studies were aimed at finding links between immunoassays or SPTs and allergy severity, but their statistical analyses were limited to either comparing distributions between groups of patients (using, for instance, the Mann-Whitney test) or to computing linear correlation coefficients [12,19]. In our approach, we used several classification rules to aid in comparing and choosing the optimal and most efficient method.…”
Section: Discussionmentioning
confidence: 99%
“…Our work differs from earlier studies in several respects. Previous studies were performed on small sample sizes of 30 to 40 patients [12,19] using a small number of measured variables, which only permitted a limited choice of discriminating predictors. Also, specific IgE to Ara-h1,2,3 were measured by SPTs instead of immunoassays [19] and although a positive response to an SPT does indeed indicate allergen sensitivity, it is still less accurate than immunoassays.…”
Section: Discussionmentioning
confidence: 99%
“…[16] The severity of a reaction does not necessarily correlate with the severity of reactions in real-life situations, as challenges are gradual and discontinued immediately if a reaction occurs. [17] Following a negative OFC in which the allergen was administered in a form not normally eaten (e.g. peanut flour or powdered egg), it is essential to perform an OFC with a meal-sized portion of the food in the state in which it is normally ingested (e.g.…”
Section: Discontinuing a Challengementioning
confidence: 99%