Does robot-assisted gait training improve ambulation in highly disabled multiple sclerosis people? A pilot randomized control trial

Pompa, Alessandra; Morone, Giovanni; Iosa, Marco; Pace, Luca; Catani, Sheila; Casillo, Paolo; Clemenzi, Alessandro; Troisi, Elio; Tonini, A.; Paolucci, Stefano; Grasso, Maria Grazia

doi:10.1177/1352458516663033

Cited by 40 publications

(63 citation statements)

References 36 publications

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“…Overall, the authors found that robot-assisted gait training might be beneficial to people with progressive MS. However, none of the treatment methodologies had a significant effect on perceived fatigue, which differs from other studies [83,108]. One explanation advanced by the authors is that the FSS might not be reliable while measuring high levels of fatigue.…”

Section: Measuring and Analyzing Fatigue In Rehabilitationcontrasting

confidence: 72%

“…A study conducted by Pompa et al found similar result with robot assisted gait training. Although, people who underwent conventional walking training did not show an improvement in subjective fatigue [83]. Straudi et al on the other hand did not find significant improvement in the perceived fatigue during robot assisted gait training [109].…”

Section: Measuring and Analyzing Fatigue In Rehabilitationmentioning

confidence: 92%

“…Robot-assisted gait training has been shown to be an effective technique for gait rehabilitation. Multiple studies highlight the benefits of robot-assisted gait training over conventional walking training [79,80,83]. A study conducted by Husemann et al showed that post stroke subjects who used a Lokomat for training had an increase in muscle mass [84].…”

Section: Robot-assisted Gait Training and Rehabilitationmentioning

confidence: 99%

“…Pompa et al studied the effect of robot-assisted gait training in PwMS with high disability in comparison to conventional walking training [83]. During this study the researchers recorded parameters for walking capacity and ability using the Rivermed Mobility Index and a modified Barthel Index VAS to measure lower limb spasticity and the FSS to measure perceived fatigue.…”

Section: Measuring and Analyzing Fatigue In Rehabilitationmentioning

confidence: 99%

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A Survey of Assistive Technologies for Assessment and Rehabilitation of Motor Impairments in Multiple Sclerosis

Rajavenkatanarayanan

Kanal

Tsiakas

et al. 2019

MTI

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Multiple sclerosis (MS) is a disease that affects the central nervous system, which consists of the brain and spinal cord. Although this condition cannot be cured, proper treatment of persons with MS (PwMS) can help control and manage the relapses of several symptoms. In this survey article, we focus on the different technologies used for the assessment and rehabilitation of motor impairments for PwMS. We discuss sensor-based and robot-based solutions for monitoring, assessment and rehabilitation. Among MS symptoms, fatigue is one of the most disabling features, since PwMS may need to put significantly more intense effort toward achieving simple everyday tasks. While fatigue is a common symptom across several neurological chronic diseases, it remains poorly understood for various reasons, including subjectivity and variability among individuals. To this end, we also investigate recent methods for fatigue detection and monitoring. The result of this survey will provide both clinicians and researchers with valuable information on assessment and rehabilitation technologies for PwMS, as well as providing insights regarding fatigue and its effect on performance in daily activities for PwMS.

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Section: Measuring and Analyzing Fatigue In Rehabilitationcontrasting

confidence: 72%

Section: Measuring and Analyzing Fatigue In Rehabilitationmentioning

confidence: 92%

Section: Robot-assisted Gait Training and Rehabilitationmentioning

confidence: 99%

Section: Measuring and Analyzing Fatigue In Rehabilitationmentioning

confidence: 99%

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A Survey of Assistive Technologies for Assessment and Rehabilitation of Motor Impairments in Multiple Sclerosis

Rajavenkatanarayanan

Kanal

Tsiakas

et al. 2019

MTI

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“…We showed that patients with high levels of disability were able to complete GXT in 10 out of 25 occasions (40% success rate) and 50% of our participants achieved 90% of their age-predicted maximal heart rates during GXT, potentially important information needed for planning of future studies among patients with high levels of MS-related disability [26,78,82,84,85,[87][88][89][90][91][92]. We found that our participants with high disability achieved 12.2% greater maximal workload during GXT as a result of training, despite small increases in maximal heart rate (1.8%), maximal respiratory exchange ratio (2.2%), and maximal V O 2 (6.6%).…”

Section: Ability To Perform Gxt and Improvements In Cardiorespiratorymentioning

confidence: 70%

Vigorous cool room treadmill training to improve walking ability in people with multiple sclerosis who use ambulatory assistive devices: a feasibility study

et al. 2020

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Background: Aerobic training has the potential to restore function, stimulate brain repair, and reduce inflammation in people with Multiple Sclerosis (MS). However, disability, fatigue, and heat sensitivity are major barriers to exercise for people with MS. We aimed to determine the feasibility of conducting vigorous harness-supported treadmill training in a room cooled to 16°C (10 weeks; 3times/week) and examine the longer-term effects on markers of function, brain repair, and inflammation among those using ambulatory aids.Methods: Ten participants (9 females) aged 29 to 74 years with an Expanded Disability Status Scale ranging from 6 to 7 underwent training (40 to 65% heart rate reserve) starting at 80% self-selected walking speed. Feasibility of conducting vigorous training was assessed using a checklist, which included attendance rates, number of missed appointments, reasons for not attending, adverse events, safety hazards during training, reasons for dropout, tolerance to training load, subjective reporting of symptom worsening during and after exercise, and physiological responses to exercise. Functional outcomes were assessed before, after, and 3 months after training. Walking ability was measured using Timed 25 Foot Walk test and on an instrumented walkway at both fast and self-selected speeds. Fatigue was measured using fatigue/energy/vitality sub-scale of 36-Item Short-Form (SF-36) Health Survey, Fatigue Severity Scale, modified Fatigue Impact Scale. Aerobic fitness (maximal oxygen consumption) was measured using maximal graded exercise test (GXT). Quality-of-life was measured using SF-36 Health Survey. Serum levels of neurotrophin (brain-derived neurotrophic factor) and cytokine (interleukin-6) were assessed before and after GXT. Results: Eight of the ten participants completed training (attendance rates ≥ 80%). No adverse events were observed. Fast walking speed (cm/s), gait quality (double-support (%)) while walking at self-selected speed, fatigue (modified Fatigue Impact Scale), fitness (maximal workload achieved during GXT), and quality-of-life (physical functioning sub-scale of SF-36) improved significantly after training, and improvements were sustained after 3months. Improvements in fitness (maximal respiratory exchange ratio and maximal oxygen consumption during GXT) were associated with increased brain-derived neurotrophic factor and decreased interleukin-6. Conclusion: Vigorous cool room training is feasible and can potentially improve walking, fatigue, fitness, and quality-of-life among people with moderate to severe MS-related disability.

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Hand Robotics Rehabilitation in Patients with Multiple Sclerosis: A Pilot Study

Tramontano¹,

Conti²,

Marziali³

et al. 2020

Methodologies and Intelligent Systems for Technology Enhanced Learning, 10th International Conference

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Does robot-assisted gait training improve ambulation in highly disabled multiple sclerosis people? A pilot randomized control trial

Abstract: RAGT improved the walking competencies in non-autonomous ambulant patients with MS, with benefits in terms of perceived fatigue.

Cited by 40 publications

References 36 publications

A Survey of Assistive Technologies for Assessment and Rehabilitation of Motor Impairments in Multiple Sclerosis

A Survey of Assistive Technologies for Assessment and Rehabilitation of Motor Impairments in Multiple Sclerosis

Vigorous cool room treadmill training to improve walking ability in people with multiple sclerosis who use ambulatory assistive devices: a feasibility study

Hand Robotics Rehabilitation in Patients with Multiple Sclerosis: A Pilot Study

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