Does oxytocin affect mind-reading? A replication study

Radke, Sina; Bruijn, Ellen R.A. de

doi:10.1016/j.psyneuen.2015.06.006

Cited by 85 publications

(84 citation statements)

References 26 publications

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“…Indeed, OT administration has been shown to have greater benefits for social cognition for individuals lower in social-emotional functioning and has generally been observed in male or clinical samples (e.g., Bartz et al, 2010a;Guastella et al, 2010), which may contribute to the lack of associations with the current gender-diverse and healthy sample. However, other work has recently failed to replicate this effect (Radke and de Bruijn, 2015) and our sample was reasonably well powered to detect effects of at least medium size, which have been observed in prior studies finding positive effects (e.g., Feeser et al, 2015). This suggests that this null main effect of OT administration on social perception in healthy adults may indeed be meaningful or that, if an effect does exist, it is smaller than previously suggested.…”

Section: Discussionsupporting

confidence: 54%

Combining oxytocin administration and positive emotion inductions: Examining social perception and analytical performance

Human

Thorson

Woolley

et al. 2017

Hormones and Behavior

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a b s t r a c t a r t i c l e i n f oIntranasal administration of the hypothalamic neuropeptide oxytocin (OT) has, in some studies, been associated with positive effects on social perception and cognition. Similarly, positive emotion inductions can improve a range of perceptual and performance-based behaviors. In this exploratory study, we examined how OT administration and positive emotion inductions interact in their associations with social and analytical performance. Participants (N = 124) were randomly assigned to receive an intranasal spray of OT (40 IU) or placebo and then viewed one of three videos designed to engender one of the following emotion states: social warmth, pride, or an affectively neutral state. Following the emotion induction, participants completed social perception and analytical tasks. There were no significant main effects of OT condition on social perception tasks, failing to replicate prior research, or on analytical performance. Further, OT condition and positive emotion inductions did not interact with each other in their associations with social perception performance. However, OT condition and positive emotion manipulations did significantly interact in their associations with analytical performance. Specifically, combining positive emotion inductions with OT administration was associated with worse analytical performance, with the pride induction no longer benefiting performance and the warmth induction resulting in worse performance. In sum, we found little evidence for main or interactive effects of OT on social perception but preliminary evidence that OT administration may impair analytical performance when paired with positive emotion inductions.

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Section: Discussionsupporting

confidence: 54%

Combining oxytocin administration and positive emotion inductions: Examining social perception and analytical performance

Human

Thorson

Woolley

et al. 2017

Hormones and Behavior

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“…Emotional empathy, but not cognitive empathy, is supported by OT (Hurlemann et al, 2010;Shamay-Tsoory, 2011). Individuals low in emotional empathy showed greater improvement after OT administration compared with those receiving a placebo (Radke and de Bruijn, 2015). Domes et al (2007) and Feeser et al (2015) observed that OT enhances interpretation of subtle social-affective cues from the eye region, measured by the RMET.…”

Section: Introductionmentioning

confidence: 99%

The relationship between aggression, empathy skills and serum oxytocin levels in male children and adolescents with attention deficit and hyperactivity disorder

Demirci

Özmen

Kilic

et al. 2016

Behavioural Pharmacology

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Although attention deficit and hyperactivity disorder (ADHD) are recognized as neurodevelopmental disorders characterized by impairment in executive functions, impairments in social functioning are often accompanied by ADHD. Oxytocin (OT) has been investigated in a number of psychiatric disorders owing to its effects on social interactions. The aim of this study was to determine the relationship between aggression, empathy and OT levels in children with ADHD. Forty male patients with ADHD, ranging in age from 7 to 18 years, and 40 healthy age-matched and sex-matched individuals were included in this study. The patients and healthy controls filled in the Buss-Perry Aggression Questionnaire and Bryant's Empathy Index for Children and Adolescents; the Reading the Mind in the Eyes test was then completed. Blood samples were collected for OT at the beginning of the study. Lower serum OT levels were observed in patients with ADHD compared with the healthy controls. Moreover, there was a negative correlation between serum OT level and aggression scores and a positive correlation between the serum OT level and empathy scores in patients with ADHD. We conclude that OT may play a role in aggression and empathy skills, affecting the social life of those with ADHD.

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“…6 and 7; but also see ref. 8), enhance empathic accuracy (9), improve encoding and recognition of happy facial expressions (10,11), increase eye contact (12), facilitate recognition of relationship words (13), increase in-group favoritism (14,15), and promote prosocial behaviors (refs. 16 and 17; but also see ref.…”

mentioning

confidence: 99%

Distinct oxytocin effects on belief updating in response to desirable and undesirable feedback

Wang

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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Humans update their beliefs upon feedback and, accordingly, modify their behaviors to adapt to the complex, changing social environment. However, people tend to incorporate desirable (better than expected) feedback into their beliefs but to discount undesirable (worse than expected) feedback. Such optimistic updating has evolved as an advantageous mechanism for social adaptation. Here, we examine the role of oxytocin (OT)-an evolutionary ancient neuropeptide pivotal for social adaptation-in belief updating upon desirable and undesirable feedback in three studies (n = 320). Using a double-blind, placebo-controlled between-subjects design, we show that intranasally administered OT (IN-OT) augments optimistic belief updating by facilitating updates of desirable feedback but impairing updates of undesirable feedback. The IN-OT-induced impairment in belief updating upon undesirable feedback is more salient in individuals with high, rather than with low, depression or anxiety traits. IN-OT selectively enhances learning rate (the strength of association between estimation error and subsequent update) of desirable feedback. IN-OT also increases participants' confidence in their estimates after receiving desirable but not undesirable feedback, and the OT effect on confidence updating upon desirable feedback mediates the effect of IN-OT on optimistic belief updating. Our findings reveal distinct functional roles of OT in updating the first-order estimation and second-order confidence judgment in response to desirable and undesirable feedback, suggesting a molecular substrate for optimistic belief updating.oxytocin | social adaptation | confidence | belief updating | optimism

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Does oxytocin affect mind-reading? A replication study

Cited by 85 publications

References 26 publications

Combining oxytocin administration and positive emotion inductions: Examining social perception and analytical performance

Combining oxytocin administration and positive emotion inductions: Examining social perception and analytical performance

The relationship between aggression, empathy skills and serum oxytocin levels in male children and adolescents with attention deficit and hyperactivity disorder

Distinct oxytocin effects on belief updating in response to desirable and undesirable feedback

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