Does obesity have an effect on outcomes in triple-negative breast cancer?

Mowad, Ronny; Chu, Quyen D.; Li, Benjamin D.L.; Burton, Gary V.; Ampil, Federico L.; Kim, Roger H.

doi:10.1016/j.jss.2013.05.037

Cited by 52 publications

(56 citation statements)

References 25 publications

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“…Ademuyiwa et al (11) reported that the mean tumor size in the overweight, obese and normoweight groups was 2.5, 2.3 and 2.2 cm, respectively. Another research from Louisiana (10) reported that the tumor size in obese, overweight and underweight/normoweight patients was 3.5, 3.3 and 2.3 cm, respectively, and that the overweight/obese patients had larger tumors (P=0.02), a higher T stage (P=0.001) and higher tumor grade (P=0.01) compared with the normoweight/underweight group. According to a research from China (13), where patients were classified based on tumor size, among patients with larger-sized tumors (>2 cm), 63 (14); however, the conclusions were based on analyses indicating that obesity exerts diverse effects on the risk of TNBC in pre-vs. postmenopausal women.…”

Section: Tnbc Patients Tend To Have Larger Tumors Higher T Stage Andmentioning

confidence: 94%

“…Although there is evidence linking body weight to outcome in breast cancer patients, the association between BMI and clinical survival in TNBC is less clear. It was previously demonstrated that obesity was not associated with decreased OS or disease-free survival (DFS) in patients with TNBC (10). The results of three adjuvant trials clearly established an association between higher BMI and higher risk of recurrence and death in luminal A breast cancer, but not in TNBC (96).…”

Section: Prognosis Of Tnbcmentioning

confidence: 98%

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Triple‑negative breast cancer and its?association with obesity (Review)

Zou

Chen

et al. 2017

mol clin onc

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Abstract. Triple-negative breast cancer (TNBC) is a subtype of breast cancer that lacks expression of the estrogen and progesterone receptor and does not overexpress human epidermal growth factor 2 receptor protein. TNBC is associated with special characteristics, including aggressiveness, poor prognosis and poor response to treatment, and has been attracting increasing attention worldwide. Obesity is a well-documented factor exerting a significant effect on the development of breast cancer, including TNBC. The purpose of the present review was to focus on the association between obesity and TNBC and provide a summary of novel research findings. The aim was to highlight the association between TNBC and obesity and provide an overview of novel outlooks on clinical issues, biological rationale, novel targeted therapies and prognosis, in order to draw attention to the significance of weight management, primary prevention, early diagnosis and treatment of this intractable disease.

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Section: Tnbc Patients Tend To Have Larger Tumors Higher T Stage Andmentioning

confidence: 94%

Section: Prognosis Of Tnbcmentioning

confidence: 98%

Triple‑negative breast cancer and its?association with obesity (Review)

Zou

Chen

et al. 2017

mol clin onc

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“…Overall survival and disease-free survival were reported to be significantly shorter in premenopausal obese women with TNBC compared to non-obese women [21]. However, in another study, obesity was not associated with decreased survival in patients with TNBC [22], indicating the need for more and larger studies to clarify this relationship.…”

Section: Obesity/metabolic Syndrome and Breast Cancer Subtypesmentioning

confidence: 99%

Metabolic Syndrome and Breast Cancer: Is There a Link?

Hauner

2014

Breast Care

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Summary Epidemiological data suggest a close link between obesity and breast cancer, the most frequently occurring cancer in women. The metabolic syndrome is typically associated with abdominal obesity and comprises disturbances in glucose and/or lipid metabolism and/or hypertension. Recent studies have established a specific association between the metabolic syndrome - as well as its components - and breast cancer, indicating both an increased risk of developing breast cancer and a poorer prognosis. In premenopausal women, obesity might have a protective effect only on receptor-positive tumors, whereas a positive association was observed between obesity/abdominal obesity and an increased risk of triple-negative breast cancer (TNBC). Overall survival and disease-free survival were reported to be significantly shorter in premenopausal obese women with TNBC compared to non-obese women, but these results are still inconsistent and need further research. The metabolic syndrome is characterized by a state of insulin resistance/hyperinsulinemia and subacute chronic inflammation, with both conditions offering a plausible mechanistic link towards breast cancer. Thus, in addition to their increased risk of cardiovascular morbidity and mortality, women with this syndrome represent a group at elevated risk of developing breast cancer and with poorer prognosis.

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“…It is possible that our results are due to an increased proportion of triple-negative breast cancer patients within our obese or overweight groups. However, we previously examined the impact of obesity in triple-negative breast cancer patients and found no association with poorer survival [18]. Furthermore, the aforementioned NSABP B-14 study specifically demonstrated no association between obesity and adverse outcomes among patients with ER-positive breast cancer [11].…”

Section: Discussionmentioning

confidence: 93%