Does Mean Platelet Volume Decrease in the presence of Coronary Artery Fistula?

Abstract

Background Coronary artery fistula (CAF) is an abnormal connection that links a coronary artery to a cardiac chamber or another major blood vessel. Several studies have shown the association between mean platelet volume (MPV) and cardiovascular diseases. In the literature, there is no previous study about the association between hematologic parameters and congenital CAF. For this reason, we aimed to investigate the association of MPV with CAF. Methods 70 patients with normal coronary arteries and 50 with coronary artery fistulas were included. Routine blood and biochemical parameters were measured before the arteriography. Differences between groups for continuous variables were analyzed with t- test or Mann-Whitney test. P values < 0.05 were considered significant. Regression analysis was used to find independent predictors of CAF. Results Baseline patient demographics, including age and clinical risk factors, were similar between the groups. Compared to the control group, median (IQR) High-density lipoprotein cholesterol (HDL) levels were significantly higher (p=0.04) and MPV levels were significantly lower in the CAF group (8.84 ± 1.71fL vs. 10.43 ± 1.34, p < 0.001). In the multivariate analysis, only MPV was a significant predictor of CAF (p < 0.001, 95% CI for OR: 0.438 (0.306-0.629). A negative correlation was found between MPV and fistulae in Pearson's correlation test (r: -0.454, p < 0.001). An MPV level of < 9,6 fL showed sensitivity, specificity, positive predictive value and negative predictive value of 80%, 68%, 71% and 78% respectively (AUC = 0.766, 95% CI, 0.678-0.854) for the prediction of CAF. Conclusion The present study suggests that MPV may decrease in patients with CAF.

White blood cells and platelet profiles of diabetic patients at University of Gondar specialized referral hospital: A comparative cross‐sectional study

“…Even if MPV was found to be higher in most cardiovascular diseases, however, it was found to be lower in coronary artery fistula patients. 19 Similarly, MPV values of patients with nasal polyps and Hashimoto's thyroiditis were significantly lower than that of healthy subjects. 20,21 In the present study, we tried to compare the WBC and platelet parameters in patients with and without diabetes and also tried to find out the correlation of hematological parameters with blood pressure and anthropometric measurements.…”

Importance of haemogram parameters for prediction of the time of birth in women diagnosed with threatened preterm labour

“…17 The NLR is associated with diabetes mellitus, 18 thyroiditis, 19 and thyroid nodules. 20 Similarly, MPV is associated with diabetes mellitus, 21 inflammatory conditions, 22 cardiac conditions, 23 and thyroid conditions. 24 Use of CBC parameters in the field of obstetrics and perinatology has recently been investigated.…”