Current Opinion in Lipidology volume 27, issue 4, P382-387 2016 DOI: 10.1097/mol.0000000000000299 View full text
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Martin P. Bogsrud, Stine M. Ulven, Kirsten B. Holven

Abstract: Current data suggest that the dominating factor of the familial hypercholesterolemia (FH) phenotype is the mutation and not the inheritance, however, maternal inheritance of FH has been reported to adversely affect FH phenotype in terms of increased mortality. More knowledge about how intrauterine hypercholesterolemia during pregnancy influences epigenetic modifications and later cardiovascular disease risk in offspring is needed and this may open up new avenues of treatment of pregnant women with familial hyp…

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