Does Glyphosate Acting as a Glycine Analogue Contribute To ALS?

Abstract

Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease involving several protein mutations in glycine-rich regions with limited treatment options. 90-95% of all cases are non-familial with epidemiological studies showing a significant increased risk in glyphosate-exposed workers. In this paper, we propose that glyphosate, the active ingredient in Roundup®, plays a role in ALS, mainly through mistakenly substituting for glycine during protein synthesis, disruption of mineral homeostasis as well as setting up a state of dysbiosis. Mouse models of ALS reveal a pre-symptomatic profile of gut dysbiosis. This dysbiotic state initiate a cascade of events initially impairing metabolism in the gut, and, ultimately, through a series of intermediate stages, leading to motor neuron axonal damage seen in ALS. Lipopolysaccharide, a toxic by-product of dysbiosis which contributes to the pathology, is shown to be statistically higher in ALS patients. In this paper we paint a compelling view of how glyphosate exerts its deleterious effects, including mitochondrial stress and oxidative damage through glycine substitution. Furthermore, its mineral chelation properties disrupt manganese, copper and zinc balance, and it induces glutamate toxicity in the synapse, which results in a die-back phenomenon in axons of motor neurons supplying the damaged skeletal muscles.

Naturopathy Education, Social Cognitive Theory, PrecedeProceed Model, and Lesson Plan

“…Fast food and a poor diet cause Cancer, Diabetes, Lupus, and many other diseases. This lesson plan will prove the undisputable links between all disease and a common Western diet [24][25][26]. Cancer and many diseases are also caused by other factors in the environment such as genetically modified foods (GMO's), flu shots, child and adult vaccines, prescription drugs, and over-the-counter drugs.…”

Can glyphosate’s disruption of the gut microbiome and induction of sulfate deficiency explain the epidemic in gout and associated diseases in the industrialized world?

“…Three recent reviews of glyphosate have centred on the idea that glyphosate, acting as an amino acid analogue of glycine, may become incorporated into proteins in place of glycine through a coding error during protein synthesis [48][49][50]. The first study by Samsel and Seneff showed how disruption of multiple proteins in the body with highly conserved glycines could easily explain the correlations seen in the Swanson et al paper [48].…”

“…The first study by Samsel and Seneff showed how disruption of multiple proteins in the body with highly conserved glycines could easily explain the correlations seen in the Swanson et al paper [48]. The study by Seneff et al [49] focused specifically on ALS, and showed that a large number of proteins implicated in ALS have multiple glycine dependencies. The follow-on study by Samsel and Seneff [50] linked glyphosate to multiple autoimmune diseases via molecular mimicry due to resistance to proteolysis of glyphosate-contaminated foreign proteins.…”

“…A study based in New Zealand found that Caucasians consuming four or more drinks sweetened with high-fructose corn syrup per day had a nearly sevenfold increased risk for gout compared to those consuming none [91]. It has been argued that fructose metabolism by the gut bacteria is disrupted by glyphosate, in part due to its blockage of the shikimate pathway [49], and this would result in an excessive concentration of fructose delivered to the colon, which would likely promote the growth of fungi.…”

Amyotrophic lateral sclerosis as a protein level, non-genomic disease: Therapy with S2RM exosome released molecules

“…Most ALS experts think these brain afflictions have multiple causes, including genetics, epigenetics[ 4 , 5 ], poor diet, lack of exercise, stress, and a variety of environmental agents, including pathogens[ 6 ], pesticides, for example, pentachlorobenzene, and other chemicals, such as PCBs and formaldehyde[ 7 ]. A recent New England study found pesticides, solvents, or heavy metals, increased the risk of ALS[ 8 ], and Seneff et al[ 9 ] propose that glyphosate (Roundup) causes a number of mechanistic abnormalities associated with ALS, including protein misfolding, and elevated levels of glutamate[ 10 ]. Surprisingly, even silver nanoparticles 100 nm in diameter, commonly used in personal, commercial, and industrial products can, when in aerosol form, be absorbed by the nasal mucosa and travel to the brain where they elicit a microglial, potentially inflammatory, response[ 11 ].…”