Does flow character of cardiopulmonary bypass make a difference?

Louagie, Yves; González, M.; Collard, Édith; Mayné, Alain; Gruslin, André; Jamart, Jacques; Buche, Michel; Schoevaerdts, Jean-Claude

doi:10.1016/s0022-5223(19)33894-2

Cited by 45 publications

(21 citation statements)

References 19 publications

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“…Thirty-nine studies were excluded after examining the entire manuscript. The reasons 56 1981 Cohort study 59 Canada Effectiveness Lindberg et al 54 1984 Cohort study 20 Norway Effectiveness Driessen et al 52 1991 Cohort study 50 Belgium Effectiveness Louagie et al 15 1992…”

Section: Resultsmentioning

confidence: 99%

“…Of the randomized trials, one study was of "fair" quality, 55 and the remaining randomized trials were of "poor" quality. 15,53,57 Murkin et al trial showed a significant protective effect of PP in reducing the incidence of in-hospital mortality (1 of 158 vs. 8 of 158, p = 0.018). 55 The "poor" quality trials did not show any difference in the mortality between pulsatile and NP groups.…”

Section: Effect Of Pp On Mortalitymentioning

confidence: 97%

“…Eight studies assessed the effectiveness of pulsatile flow on the total in-hospital mortality. 15,[51][52][53][54][55][56][57] Four studies were randomized trails and the remaining were cohort studies. Of the randomized trials, one study was of "fair" quality, 55 and the remaining randomized trials were of "poor" quality.…”

Section: Effect Of Pp On Mortalitymentioning

confidence: 99%

“…55 The "poor" quality trials did not show any difference in the mortality between pulsatile and NP groups. 15,53,57 However, these trials were underpowered to detect a mortality difference.…”

Section: Effect Of Pp On Mortalitymentioning

confidence: 99%

“…9 On the other hand, several clinical studies have been unable to detect a benefit associated with PP. [10][11][12][13][14][15] Although the subject has been discussed frequently during the past decades, studies have advocated conflicting recommendations. As a result, the optimal perfusion characteristic during CPB is still in debate.…”

mentioning

confidence: 99%

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Pulsatile Versus Nonpulsatile Cardiopulmonary Bypass Flow: An Evidence-Based Approach

Alghamdi

Latter

2006

J Cardiac Surgery

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Section: Resultsmentioning

confidence: 99%

Section: Effect Of Pp On Mortalitymentioning

confidence: 97%

Section: Effect Of Pp On Mortalitymentioning

confidence: 99%

Section: Effect Of Pp On Mortalitymentioning

confidence: 99%

mentioning

confidence: 99%

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Pulsatile Versus Nonpulsatile Cardiopulmonary Bypass Flow: An Evidence-Based Approach

Alghamdi

Latter

2006

J Cardiac Surgery

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Effect of non-pulsatile renal blood flow on plasma erythropoietin

Krafte-Jacobs

1998

Am. J. Hematol.

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Erythropoietin is a hormone responsible for regulation of red blood cell production. Circulating erythropoietin values are regulated by renal oxygen supply, which is determined by hemoglobin concentration, hemoglobin oxygen saturation, and renal blood flow. Previous animal and human studies regarding erythropoietin regulation have assumed pulsatile renal blood flow. During cardiopulmonary bypass, non-pulsatile renal perfusion has been shown to result in decreased glomerular filtration rate and decreased renal blood flow in comparison to pulsatile perfusion. Repair of congenital heart disease during cardiopulmonary bypass is an attractive circumstance in which to study the effect of non-pulsatile blood flow on erythropoietin production. The hypothesis in this study was that non-pulsatile perfusion would result in increased erythropoietin production because of decreased renal oxygen supply. Fourteen children with congenital heart disease and without preoperative renal insufficiency or anemia were enrolled in the study. All patients underwent cardiopulmonary bypass with non-pulsatile flow. In addition, 10 control patients without congenital heart disease were enrolled. Six cardiopulmonary bypass patients had 1.5- to 6-fold increases in plasma erythropoietin concentrations from baseline. These patients had longer cardiopulmonary bypass times, more commonly performed under low flow deep hypothermic conditions. The remaining 8 patients with congenital heart disease, and all control patients, did not develop increased postoperative erythropoietin concentrations. The conditions under which cardiopulmonary bypass are performed appear to influence postoperative circulating erythropoietin concentrations.

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Effect of non‐pulsatile renal blood flow on plasma erythropoietin

Krafte-Jacobs

1998

Am. J. Hematol.

View full text Add to dashboard Cite

Erythropoietin is a hormone responsible for regulation of red blood cell production. Circulating erythropoietin values are regulated by renal oxygen supply, which is determined by hemoglobin concentration, hemoglobin oxygen saturation, and renal blood flow. Previous animal and human studies regarding erythropoietin regulation have assumed pulsatile renal blood flow. During cardiopulmonary bypass, non-pulsatile renal perfusion has been shown to result in decreased glomerular filtration rate and decreased renal blood flow in comparison to pulsatile perfusion. Repair of congenital heart disease during cardiopulmonary bypass is an attractive circumstance in which to study the effect of non-pulsatile blood flow on erythropoietin production. The hypothesis in this study was that non-pulsatile perfusion would result in increased erythropoietin production because of decreased renal oxygen supply. Fourteen children with congenital heart disease and without preoperative renal insufficiency or anemia were enrolled in the study. All patients underwent cardiopulmonary bypass with non-pulsatile flow. In addition, 10 control patients without congenital heart disease were enrolled. Six cardiopulmonary bypass patients had 1.5-to 6-fold increases in plasma erythropoietin concentrations from baseline. These patients had longer cardiopulmonary bypass times, more commonly performed under low flow deep hypothermic conditions. The remaining 8 patients with congenital heart disease, and all control patients, did not develop increased postoperative erythropoietin concentrations. The conditions under which cardiopulmonary bypass are performed appear to influence postoperative circulating erythropoietin concentrations. Am.

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Does flow character of cardiopulmonary bypass make a difference?

Cited by 45 publications

References 19 publications

Pulsatile Versus Nonpulsatile Cardiopulmonary Bypass Flow: An Evidence-Based Approach

Pulsatile Versus Nonpulsatile Cardiopulmonary Bypass Flow: An Evidence-Based Approach

Effect of non-pulsatile renal blood flow on plasma erythropoietin

Effect of non‐pulsatile renal blood flow on plasma erythropoietin

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