Does exogenous nitric oxide influence tympanosclerosis? An experimental study

Atmaca, Sinan; Erol, Yesim; Çoban, Ahmet Yılmaz; Yıldız, Levent; Çengel, Senem; Koyuncu, Mehmet

doi:10.1016/j.ijporl.2008.09.008

Cited by 5 publications

(4 citation statements)

References 14 publications

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“…Atmaca et al . administered saline to the right middle ear and nitric oxide to the left middle ear of rats via myringotomy 20 . Histopathological examination of the middle-ear bullae did not identify significant differences in tympanosclerosis formation.…”

Section: Discussionmentioning

confidence: 87%

Genetic polymorphisms affecting antioxidant enzymes are present in tympanosclerosis patients

et al. 2016

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Section: Discussionmentioning

confidence: 87%

Genetic polymorphisms affecting antioxidant enzymes are present in tympanosclerosis patients

et al. 2016

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“…They demonstrated that NO and superoxide were also associated with MS formation. However, there was a report that exogenous nitric oxide application did not change the occurrence of TS in a rat model 21…”

Section: Discussionmentioning

confidence: 92%

The effect of topical sodium thiosulfate in experimentally induced myringosclerosis

Park

Kim

2010

The Laryngoscope

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“…One of them suggests that oxygen-derived free radicals may be an aetiological factor in the development of TS [3,5] . However, Atmaca et al [28] demonstrated that exogenous nitric oxide application did not alter the occurrence of TS. Consequently, the use of antioxidants in its prevention came to prominence and different antioxidants were studied [6][7][8][9][10][11] .…”

Section: Discussionmentioning

confidence: 98%

Does Resveratrol Have a Protective Effect on Tympanosclerosis Formation in Experimentally Induced Otitis Media?

Kurnaz¹,

Aksoy²,

Güvenç³

et al. 2014

Int Adv Otol

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OBJECTIVE:To evaluate the effects of resveratrol on tympanosclerosis in an experimental rat model by otomicroscopic, histopathological, and immunohistochemical examinations, and measurement of malondialdehyde levels. MATERIALS and METHODS:Twenty albino Wistar rats were used in the study. Four were randomly selected as negative controls, with no treatment or intervention. The ears of 16 rats were inoculated with Streptococcus pneumonia Type 3. They were divided into two Groups: resveratrol, at 20 mg/ kg/day dissolved in 10% ethanol, was administered orally to the resveratrol Group for 6 weeks; 10% ethanol was administered to the control Group in the same manner. Blood samples were taken for malondialdehyde measurements after the first and sixth weeks. After otomicroscopic examinations, rats were sacrificed at the end of 6 weeks for histopathological and immunohistochemical (matrix metalloproteinases 2 and 9) examinations. Livers of rats were removed for malondialdehyde measurements. RESULTS:Otomicroscopic and histopathological evaluations revealed no significant difference between the Groups. Plasma malondialdehyde level of the resveratrol Group in the first week was lower than that of the control Group (p<0.05). There was no difference in plasma and liver tissue malondialdehyde levels after 6 weeks. There was a significant difference in staining for matrix metalloproteinase 9 of tympanic membranes between the resveratrol and control Groups (p<0.05). CONCLUSION:Resveratrol has potential antioxidant activity and significantly decreases malondialdehyde levels in the first week. It has an inhibitory effect on matrix metalloproteinase 9. However, it appears to be ineffective in the prevention of tympanosclerosis when used alone, according to otomicroscopic and histopathological evaluations.

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Does exogenous nitric oxide influence tympanosclerosis? An experimental study

Cited by 5 publications

References 14 publications

Genetic polymorphisms affecting antioxidant enzymes are present in tympanosclerosis patients

Genetic polymorphisms affecting antioxidant enzymes are present in tympanosclerosis patients

The effect of topical sodium thiosulfate in experimentally induced myringosclerosis

Does Resveratrol Have a Protective Effect on Tympanosclerosis Formation in Experimentally Induced Otitis Media?

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